The Use of Platelet-Rich Plasma in Aesthetic and Regenerative Medicine: A Comprehensive Review

Pensato, Rosita; Padula, Simone La

doi:10.1007/s00266-022-02781-2

Cited by 3 publications

(7 citation statements)

References 21 publications

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“…Sharing similar dermal restructuring purposes, the energy-based laser and radiofrequency technologies and Platelet-Rich Plasma (PRP) might be the most 426 congruous comparators to PN HPT. [14][15][16][17] However, only PRP shares the intradermal administration technique with PN HPT. PRP is a cocktail of growth factors like platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), transforming growth factor beta (TGFβ), and epithelial growth factor (EGF) that improve fibroblast proliferation and differentiation, contributing to skin rejuvenation and smoother and tighter skin.…”

Section: Discussionmentioning

confidence: 99%

Polynucleotides HPT for Asian Skin Regeneration and Rejuvenation

Lim,

Liew,

Tee

et al. 2024

CCID

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Even lightly compromised skin may impact self-esteem and social behaviour. After intradermal infiltration, natural-origin Polynucleotides High Purification Technology (PN HPT) promote new collagen and extracellular matrix production, translating into a physiological correction of the ageing skin. The study aimed to explore the benefits of intradermal PN HPT on the four perceptual skin quality categories "Skin Tone Evenness", "Skin Surface Evenness", "Skin Firmness", and "Skin Glow" in a representative sample of 30 Asian subjects (mean age 40.2± 11.4 years old). Methods: Study protocol: three intradermal injections of a PN HPT-based Class III CE-marked medical device at T0 (baseline assessment and first treatment session), T1 (four weeks after baseline), and T2 (eight weeks after baseline), with efficacy and safety evaluations at T1, T2, T3 (four months after baseline) and T4 (six months after baseline). Quantitative and qualitative assessments: 3D skin analysis system QuantifiCare and Global Aesthetic Improvement Scale (GAIS, Investigator and Patient subscales). Results: PN HPT treatment led to a meaningful and statistically significant improvement of the skin surface, firmness, pigmentation, and radiance, with no early-or late-onset adverse events and benefits persisting up to the sixth-month visit in all subjects. At T4, 33% and 43% of treated subjects felt "Much Improved" and "Very Much Improved" (optimal result); 56% and 44% of treated subjects felt "Satisfied" or "Very Satisfied". At T4, the mean Investigator GAIS scores were 3.33 out of 5.0 for the "Skin Tone Evenness" skin quality perceptual category, 3.46 for the "Skin Surface Evenness" category, 3.61 for "Skin Firmness", and 3.45 per for the radiance determinant of the "Skin Glow" category. Conclusion: Intradermal treatment with the PN HPT-based medical device led to a meaningful improvement of the skin surface, firmness, pigmentation, and radiance with complete safety. The aesthetic benefits persisted up to the sixth-month visit in all subjects.

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Section: Discussionmentioning

confidence: 99%

Polynucleotides HPT for Asian Skin Regeneration and Rejuvenation

Lim,

Liew,

Tee

et al. 2024

CCID

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“…For downstream use, PRP must be reactivated. Exogenous calcium activators can be added to PRP to promote the release of biologically active proteins such as growth factors ( 37 ). This step can be accomplished with calcium activators such as calcium chloride, calcium gluconate, or thrombin ( 38 ).…”

Section: Current Understanding Of Prpmentioning

confidence: 99%

Application of platelet-rich plasma in spinal surgery

et al. 2023

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With the aging of the population and changes in lifestyle, the incidence of spine-related diseases is increasing, which has become a major global public health problem; this results in a huge economic burden on the family and society. Spinal diseases and complications can lead to loss of motor, sensory, and autonomic functions. Therefore, it is necessary to identify effective treatment strategies. Currently, the treatment of spine-related diseases includes conservative, surgical, and minimally invasive interventional therapies. However, these treatment methods have several drawbacks such as drug tolerance and dependence, adjacent spondylosis, secondary surgery, infection, nerve injury, dural rupture, nonunion, and pseudoarthrosis. Further, it is more challenging to promote the regeneration of the interstitial disc and restore its biomechanical properties. Therefore, clinicians urgently need to identify methods that can limit disease progression or cure diseases at the etiological level. Platelet-rich plasma (PRP), a platelet-rich form of plasma extracted from venous blood, is a blood-derived product. Alpha granules contain a large number of cytokines, such as platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), epidermal growth factor, platelet factor 4 (PF-4), insulin-like growth factor-1 (IGF-1), and transforming growth factor-β (TGF-β). These growth factors allow stem cell proliferation and angiogenesis, promote bone regeneration, improve the local microenvironment, and enhance tissue regeneration capacity and functional recovery. This review describes the application of PRP in the treatment of spine-related diseases and discusses the clinical application of PRP in spinal surgery.

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“…Furthermore, they stimulate the formation of collagen and extracellular matrix components, which aid in skin repair and regeneration as well as effectively improve skin barrier, immune, stress, and other physiological functions. 6,7 PRP has widely used in cosmetic practice, like rejuvenation, acne, hair loss, combined fat grafting, or combined laser treatment. [7][8][9][10][11][12][13] Since the first publications in this area in 2001, several researchers have discussed the benefits of PRP in clinical aesthetic treatments, but a systematic analysis of previous research and forecasting of future trends is still lacking.…”

Section: Introductionmentioning

confidence: 99%

“…6,7 PRP has widely used in cosmetic practice, like rejuvenation, acne, hair loss, combined fat grafting, or combined laser treatment. [7][8][9][10][11][12][13] Since the first publications in this area in 2001, several researchers have discussed the benefits of PRP in clinical aesthetic treatments, but a systematic analysis of previous research and forecasting of future trends is still lacking.…”

Section: Introductionmentioning

confidence: 99%

“…Together, these growth factors and cytokines play a key role in cell proliferation, migration, differentiation, and angiogenesis. Furthermore, they stimulate the formation of collagen and extracellular matrix components, which aid in skin repair and regeneration as well as effectively improve skin barrier, immune, stress, and other physiological functions 6,7 . PRP has widely used in cosmetic practice, like rejuvenation, acne, hair loss, combined fat grafting, or combined laser treatment 7–13 .…”

Section: Introductionmentioning

confidence: 99%

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A bibliometric analysis of trends in the application of platelet‐rich plasma in cosmetics research between 2001 and 2022

Feng,

Yang,

et al. 2023

J of Cosmetic Dermatology

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BackgroundSeveral studies have been conducted on using platelet‐rich plasma (PRP) to treat cosmetic issues. Nonetheless, no bibliometric analyses of publications in this field exist. Bibliometrics is an effective tool for methodically assessing the current state of research on a particular topic. This study examines the literature published in this field since 2000 and depicts the resulting network.MethodsThe Web of Science Core Collection was searched for any publications mentioning the use of PRP in cosmetic or aesthetic therapy published between 2001 and 2022. The author, region, institution, journal, cited journal, and keywords were extracted, and the bibliometric analysis was carried out using CiteSpace and R studio.ResultsThere were a total of 306 items retrieved. The first publication in this field appeared in 2001, and the number of articles published increased over the next 21 years. Saedi Nazanin is the author with the most publications. The most prolific nations and institutions were the United States and the Fourth Military Medical University, respectively. Similarly, most articles and citations were found in the Journal of Cosmetic Dermatology and Plastic and Reconstructive Surgery. After performing a cluster analysis on the keywords of published publications, we discovered that most of the published literature focused on using PRP in rejuvenation, mechanism, and combination with MSCs. These topics are still at the frontier of future research.ConclusionSince the first study in this field was published in 2001, PRP used in cosmetic clinics has been studied. Although early effects have been observed, numerous challenges remain, including a lack of higher‐quality clinical studies and explanations of PRP's mechanism. The bibliometric analysis conducted for the purpose of this article provides a summary of academic hotspots and research frontiers, as well as insights and pointers for future productive research.

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The Use of Platelet-Rich Plasma in Aesthetic and Regenerative Medicine: A Comprehensive Review

Cited by 3 publications

References 21 publications

Polynucleotides HPT for Asian Skin Regeneration and Rejuvenation

Polynucleotides HPT for Asian Skin Regeneration and Rejuvenation

Application of platelet-rich plasma in spinal surgery

A bibliometric analysis of trends in the application of platelet‐rich plasma in cosmetics research between 2001 and 2022

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