Endo-perio lesion is the association of periodontal and pulpal disease contained in the same dental site. In this case, periodontal plastic surgery was performed for the treatment of a periodontal defect that occurred as a result of iatrogenic perforation during endodontic treatment.A 45-year-old female patient was referred because of a non-aesthetic condition and gingival pain in the maxillary anterior area. It was diagnosed as an endo-perio lesion of primary endodontic with secondary periodontal involvement. Initial treatment including the removal of etiological factors, scaling and root planning, and oral hygiene instruction was carried out. After phase I therapy, for treatment of the remaining gingival recession, a laterally positioned flap (LPF) design, which has an excellent post-operative healing process, was combined with platelet-rich fibrin (PRF) obtained from autologous blood. The usage of a LPF design combined with PRF for the treatment of the endo-perio lesion as a result of iatrogenic damage showed satisfactory results such as root coverage, an aesthetic condition with an adequate band of keratinized tissue, and reduced postoperative discomfort.