The use of plasma rich in growth factors (PRGF) in guided tissue regeneration and guided bone regeneration. A review of histological, immunohistochemical, histomorphometrical, radiological and clinical results in humans

Solakoglu, Önder; Heydecke, Guido; Amiri, Niusha; Anitua, Eduardo

doi:10.1016/j.aanat.2020.151528

Cited by 53 publications

(48 citation statements)

References 63 publications

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“…Three-dimensional maxillary bone volume recoveries choosing autogenous bone graft is today a stable and predictable treatment option. On the other hand, it has been underlined how the bone collected from the same patient's body areas is usually grafted with postoperative difficulties, biological damages, irritation, or pain at the bone-grafting zone [ 13 – 18 ]. Nowadays, the biomaterials of use for facial bone reconstructions are many and of different derivation; moreover, thanks to the digital; it is possible to calculate the quantity of biomaterial needed or obtain the printing of the biomaterial with the ideal shape [ 19 – 25 ].…”

Section: Introductionmentioning

confidence: 99%

“…Accordingly, to the National Science Foundation workshop in 1988, the term “tissue engineering” was officially established in order to mean the application of principles and methods of engineering and life sciences toward the fundamental understanding of structure-function relationships in normal and pathological mammalian tissues and the development of biological substitutes to restore, maintain, or improve tissue function [ 13 , 27 – 30 ].…”

Section: Introductionmentioning

confidence: 99%

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Growth Factors in Oral Tissue Engineering: New Perspectives and Current Therapeutic Options

Fiorillo

Cervino

Galindo‐Moreno

et al. 2021

BioMed Research International

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The present investigation is aimed at systematically analyzing the recent literature about the innovative scaffold involved in the reconstructive surgeries by applying growth factors and tissue engineering. An extensive review of the contemporary literature was conducted according to the PRISMA guidelines by accessing the PubMed, Embase, and Scopus Elsevier databases. Authors performed the English language manuscript research published from 2003 to 2020. A total of 13 relevant studies were included in the present review. The present systematic review included only papers with significant results about correlation between scaffold, molecular features of growth factor, and reconstructive surgeries in oral maxillofacial district. The initial research with filters recorded about 1023 published papers. Beyond reading and considering of suitability, only 42 and then 36 full-text papers were recorded for the revision. All the researches recorded the possibility of using growth factors on rebuilding atrophic jaws. Different growth factors like morphogenetic factors, cytokines, and inflammatory ones and their application over different scaffold materials were recorded. Further investigations should be required in order to state scientific evidence about a clear advantage of applying tissue engineering for therapeutic purpose.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Growth Factors in Oral Tissue Engineering: New Perspectives and Current Therapeutic Options

Fiorillo

Cervino

Galindo‐Moreno

et al. 2021

BioMed Research International

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“…O, Heydecke G, Amiri N et al2020 [16] The use of plasma rich in growth factors (PRGF) in guided tissue regeneration and guided bone regeneration. A review of histological, Immunohistochemical, histo-morphometrical, radiological and clinical results in humans.…”

Section: Solakoglu €mentioning

confidence: 99%

Application of PRP (platelet-rich plasma) in surgical periodontal therapy: overview

Mlachkova

Dosseva-Panova

Popova

2021

Biotechnology & Biotechnological Equipment

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Clinical and morphological manifestation of periodontitis is associated with persistent inflammation of the gingiva, loss of connective tissue attachment, formation of a periodontal pocket and loss of alveolar bone, which indicate variations in a wide range in different individuals. The main purpose of non-surgical therapy for periodontitis is to achieve long-term control of inflammation, and the ultimate goal of therapy is the regeneration of periodontal tissues affected by destruction. The unique anatomy and structure of the entire periodontal complex determine the course of more complex processes related to the restoration of periodontal structures affected by destruction, which include coordination of response by four different types of tissues: epithelial tissue, connective tissue, periodontal ligament and bone. Periodontal regeneration is defined as the regeneration of main tooth-supporting tissues: alveolar bone, periodontal ligament, cementum and attachment. Modern modalities for carrying out the periodontal regeneration include the use of bone substitutes, guided tissue regeneration with barrier membranes, treatments with flaps and a variety of additional components, such as: soft tissue grafts, root biomodifiers and growth factors, the carrier of which is platelet-rich plasma (PRP). This mini-review provides an overview of PRP applied in surgical periodontal therapy. Data of the initial experiences with this method are included, as well as brief references on its usage in the clinical practice. There is no substitute material in the modern literature shown as the gold standard in the treatment of periodontal bone defects.

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“…Horizontal periosteal incisions are not provided, the soft tissues can be mobilized with the Soft Brushing Technique (J. Choukroun), disorganizing the periosteal collagen fiber as the brush tools don't cut anything avoiding conventional flap: the aim is to decrease the tension and increase the release of the tissues, which have as more as possible to cover the new graft volume. PTFE membrane should be inserted first in lingual/palatal site, since usually is simpler; a bone graft must be fit in place, obtaining it by heterologous bone mixed with A-PRF (cut into small pieces) and solidifying with PRGF 10,11,12,13 , very handy and stable to be positioned in desired volume, overcompensating by 2-3mm. Then the membrane is curved over the graft and placed to cover whole vestibular dimension; it is very important that the membrane does not touch adjacent teeth, leaving almost 1-2mm from dental surface.…”

Section: Protocolmentioning

confidence: 99%

Simplified protocol for horizontal and vertical post-extractive GBR with intentionally exposed PTFE membrane - Case series

Cappellin¹

2020

JSPIR

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Purpose: Post-extractive sites often need soft and hard tissue regeneration in order to place implants with optimal functional and aesthetic conditions. The author proposed several techniques for bone preservation and regeneration: most of them requires release incisions and coronally advanced flap to obtain primary closure, so regain a correct alignment of keratinized gingiva makes mandatory a further surgery with a connective tissue graft from secondary surgical site. Case report: Since May 2018 we applied with some adjustments Open Barrier Technique (proposed by E. Funakoshi, 2005) in 152 post-extractive alveolar preservation and GBR; after 3-6 months we placed 194 implants, with 100% success and survival rate. Conclusions: Our simplified protocol allows performing vertical and horizontal GBR in post-extractive sites without release incisions: non resorbable PTFE membrane protects wound and bone graft for 6-8 week; secondary healing ensures thick keratinized tissue and bone maturation, suitable to place implants after 3-6 months.

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The use of plasma rich in growth factors (PRGF) in guided tissue regeneration and guided bone regeneration. A review of histological, immunohistochemical, histomorphometrical, radiological and clinical results in humans

Cited by 53 publications

References 63 publications

Growth Factors in Oral Tissue Engineering: New Perspectives and Current Therapeutic Options

Growth Factors in Oral Tissue Engineering: New Perspectives and Current Therapeutic Options

Application of PRP (platelet-rich plasma) in surgical periodontal therapy: overview

Simplified protocol for horizontal and vertical post-extractive GBR with intentionally exposed PTFE membrane - Case series

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