The use of physical hydrogels of chitosan for skin regeneration following third-degree burns

The Pharmacology of Regenerative Medicine

“…The ability to provide improved threedimensional architecture within the context of a biodegradable system that is readily implanted or sutured would augment existing technologies. Several materials, including hyaluronic acid (Scuderi et al, 2008), chitosan (Boucard et al, 2007;Yang et al, 2010), and alginate ) hydrogels as well as calcium hydroxylapatite (Goldberg et al, 2006), have been used to treat skin conditions, including acne, burns, and melanocytic nevi. In addition, several types of therapeutic agents such as antibiotics for prophylaxis , growth factors to promote healing (Fujihara et al, 2008), and other compounds (Queen et al, 2007) have been incorporated into biologically active materials (Luo et al, 2010) to promote regeneration.…”

Novel Chitin and Chitosan Materials in Wound Dressing

“…Skin repair is an important field of the tissue engineering, especially in the case of extended third-degree burns, where the current treatments are still insufficient in promoting satisfying skin regeneration. Bio-inspired bi-layered physical hydrogels only constituted of chitosan and water were processed and applied to the treatment of full-thickness burn injuries (Boucard et al, 2007). A first layer constituted of a rigid protective gel ensured good mechanical properties and gas exchanges.…”

“…At day 22, type I and IV collagens were synthesised under the granulation tissue and the formation of the dermal-epidermal junction was observed. After 100 days, the new tissue was quite similar to a native skin, especially by its aesthetic aspect and its great flexibility (Boucard et al, 2007). Ribeiro et al (2009) developed chitosan hydrogel for wound dressing.…”

Desenvolvimento De Hidrogéis De Polietileno Glicol E Alginato Para a Liberação Controlada De Bromelina

“…Os hidrogéis podem ser formados por polímeros naturais (Boucard et al, 2007) tais como ácido hialurônico, alginato, quitosana; por polímeros naturais modificados (Coviello et al, 2007), por exemplo dextrana reticulada, galactomanana metacrilatada; e por polímeros sintéticos (Sedláková et al, 1998) tais como polietileno glicol (PEG), poliacrilamida (PAAm), poli(hidroxietil metacrílico) (HEMA), poli(N-isopropilacrilamida) (PNIPAAm), entre outros.…”