The use of physical energy for tissue healing

Ventura, Carlo; Bianchi, Francesca; Cavallini, C; Olivi, Elena; Tassinari, Riccardo

doi:10.1093/eurheartj/suv010

Cited by 8 publications

(11 citation statements)

References 18 publications

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“…Our life contains a seeming infinity of rhythms, with vibrations now recordable at atomic and molecular levels, and within biochemical reactions [92][93][94]. The correlations between rhythms and life do not emerge only at the macro level and maximum systems.…”

Section: Life As a Symphony Of Oscillatory Rhythms: The Discovery Thamentioning

confidence: 99%

“…The correlations between rhythms and life do not emerge only at the macro level and maximum systems. Very recent studies show that biorhythms emerge and self sustain at the cellular and subcellular level [92][93][94]. Therefore, such rhythms are not generated by, but rather they are coordinated through the central nervous system.…”

Section: Life As a Symphony Of Oscillatory Rhythms: The Discovery Thamentioning

confidence: 99%

“…Therefore, such rhythms are not generated by, but rather they are coordinated through the central nervous system. At single cell level, molecules engaged into structural and functional plans exhibit intrinsic oscillatory rhythms that tend to progress towards phase synchronization which may set the basis for biomolecular recognition, leading to complex integrated functions that extend from single cell to the level of multicellular systems, tissues, and organs [92][93][94]. It is now evident that also the activity of our genes is expressed through rhythmic oscillatory patterns [92][93][94].…”

Section: Life As a Symphony Of Oscillatory Rhythms: The Discovery Thamentioning

confidence: 99%

“…At single cell level, molecules engaged into structural and functional plans exhibit intrinsic oscillatory rhythms that tend to progress towards phase synchronization which may set the basis for biomolecular recognition, leading to complex integrated functions that extend from single cell to the level of multicellular systems, tissues, and organs [92][93][94]. It is now evident that also the activity of our genes is expressed through rhythmic oscillatory patterns [92][93][94]. The transcription of genes into the various mRNAs, which are translated into proteins essential for cellular life, is not a "discrete" (variable for long intervals of time above or below a baseline) phenomenon over time.…”

Section: Life As a Symphony Of Oscillatory Rhythms: The Discovery Thamentioning

confidence: 99%

“…The transcription of genes into the various mRNAs, which are translated into proteins essential for cellular life, is not a "discrete" (variable for long intervals of time above or below a baseline) phenomenon over time. On the contrary, the mRNA levels rapidly oscillate with time, even in minutes and hours [92][93][94]. The connectedness of complex cellular functions resulting from gene activity arises from the synchronization of multiple oscillatory rhythms through which one or more groups of genes become expressed.…”

Section: Life As a Symphony Of Oscillatory Rhythms: The Discovery Thamentioning

confidence: 99%

See 4 more Smart Citations

Cancer Stem Cells: Foe or Reprogrammable Cells for Efficient Cancer Therapy?

Ventura¹,

Olivi²,

Cavallini³

et al. 2015

NanoWorld J

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Embryonic development and carcinogenesis share many molecular pathways and regulatory molecules. While the induction of a pluripotent state involves a significant oncogenic risk, as in induced pluripotent stem cells (iPSCs), the embryonic environment in vivo has been shown to suppress tumor development. In this review, we discuss the subtle equilibrium between the nanotopography (niche) of the hosting tissue resident stem cells and their biological dynamics, including the transformation in cancer stem cells. We review consistent findings indicating the potential for modulating the biology of human cancer stem cells by the aid of naturally occurring or synthetic molecules, including developmental stage zebrafish embryo extracts, hyaluronan, butyric acid (BA) and retinoic acid (RA), hyaluronan mixed esters of BA and RA, melatonin, vitamin D3, and endorphin peptides. Within this context, we dissect the multifaceted mechanisms orchestrated by endorphinergic systems, including paracrine cellto-cell communication, as well as the establishment of autocrine and intracrine (intracellular) peptide actions driving transcriptional responses and self-sustaining loops that behave as long-lived signals imparting features characteristic of differentiation, growth regulation and cell memory.Based upon the remarkable action of electromagnetic fields and mechanical vibration on (stem) cell signaling, differentiation, and senescence, we also consider the potential for using these physical energies as a tool to afford a fine tuning of cancer stem cell fate.On the whole, we forecast future deployment of the physical and/or chemical approaches described herein aiming at reprogramming, rather than destroying cancer stem cells, eventually placing cancer therapy within the context of Regenerative Medicine.

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Section: Life As a Symphony Of Oscillatory Rhythms: The Discovery Thamentioning

confidence: 99%

Section: Life As a Symphony Of Oscillatory Rhythms: The Discovery Thamentioning

confidence: 99%