The use of photodynamic therapy in patients with severe forms of leukoplakia

Rabinovich, O F; Im, Rabinovich; Shindich, O I; Kozhedub, A A

doi:10.17116/stomat202210105111

Cited by 1 publication

(12 citation statements)

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“…A total of 17 single-arm studies were included in this analysis, there were 16 studies in English and 1 study [ 27 ] in Russian, involving 662 participants and 702 diagnosed leukoplakia lesions treated with PDT. The basic characteristics of the included studies are shown in Table S3 (see Additional File 3 ).…”

Section: Resultsmentioning

confidence: 99%

“…Seven studies scored more than 9 points [ 19 – 21 , 24 , 26 , 28 , 32 ]. Eight studies scored equal to 9 [ 16 , 17 , 22 , 23 , 27 , 29 , 30 , 31 ], and two studies scored less than 9 [ 18 , 25 ].…”

Section: Resultsmentioning

confidence: 99%

“…A total of 11 studies involving 84 leukoplakia lesions [ 16 , 18 – 21 , 24 , 26 , 27 , 29 , 30 , 32 ] with Recurrence outcomes were analyzed. After statistical analysis using the random effects model, it was concluded that [ES = 0.13, 95%CI: (0.08, 0.18), I 2 = 71.4%, P < 0.001], as shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…In terms of the light source used in the studies, seven studies used laser-emitting diodes (LED) [ 16 , 17 , 23 , 24 , 27 , 31 , 32 ], seven studies used laser [ 18 – 22 , 25 , 30 ], two studies used other light sources [ 26 , 28 ]. The results of LED and laser test were as follows: [I 2 = 98%, P < 0.001, ES = 0.44, 95%CI: (0.16, 0.71)] and [I 2 = 87.7%, P < 0.001, ES = 0.63, 95%CI: (0.47, 0.79)], indicating that both LED and laser as the light sources for PDT treatment of leukoplakia achieved complete remission of the lesions.…”

Section: Resultsmentioning

confidence: 99%

“…In terms of wavelength, 13 studies used ≤ 640 nm [ 16 – 23 , 26 , 28 , 30 – 32 ], and three studies used > 640 nm [ 24 , 25 , 27 ]. The results of ≤ 640 nm and > 640 nm test were as follows: [I 2 = 95.8%, P < 0.001, ES = 0.46, 95%CI: (0.28, 0.64)] and [I 2 = 96.7%, P < 0.001, ES = 0.66, 95%CI: (0.36, 0.95)].…”

Section: Resultsmentioning

confidence: 99%

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Photodynamic therapy (PDT) for oral leukoplakia: a systematic review and meta-analysis of single-arm studies examining efficacy and subgroup analyses

Zhang

Gao

Wang³

2023

BMC Oral Health

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Objective This study aims to evaluate the efficacy of photodynamic therapy (PDT) in the treatment of oral leukoplakia and explore the subgroup factors that may influence its effectiveness. Methods A systematic search was conducted in PubMed, Embase, the Cochrane Library, and Web of Science databases to identify relevant studies. Meta-analysis was performed using Stata15.0 software. Cochran’s Q test and I2 statistics were used to evaluate heterogeneity, egger’s test was used to evaluate publication bias. Results The analysis of 17 studies included in this study suggests that PDT may be effective in achieving complete response (CR) [ES = 0.50, 95%CI: (0.33,0.66)], partial response (PR) [ES = 0.42, 95%CI: (0.27,0.56)], no response (NR) [ES = 0.19, 95%CI: (0.11,0.27)]in patients with oral leukoplakia. The recurrence rate was also evaluated [ES = 0.13, 95%CI: (0.08,0.18)]. Subgroup analysis showed that various factors such as light source, wavelength, medium, duration of application, clinical and pathological diagnosis classification influenced efficacy of PDT. The lesion areas of the leukoplakia after treatment were reduced by 1.97cm2 compared with those before treatment. Conclusion Our findings show that PDT is a viable treatment for oral leukoplakia. However, the effectiveness of the therapy may depend on several factors, as suggested by our subgroup analyses. (Registration no. CRD42023399848 in Prospero, 26/02/2023)

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Section: Resultsmentioning

confidence: 99%