The Use of Photoactive Polymeric Nanoparticles and Nanofibers to Generate a Photodynamic-Mediated Antimicrobial Effect, with a Special Emphasis on Chronic Wounds

Abdel Khalek, Mohamed A.; Abdelhameed, Amr M.; Abdel Gaber, Sara A.

doi:10.3390/pharmaceutics16020229

Cited by 3 publications

(1 citation statement)

References 156 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It primarily utilizes photosensitizers and the combined action of light and oxygen to locally generate ROS and induce tumor cell death. 116 , 117 However, due to the low water solubility and cytotoxicity of photosensitizers, precise delivery to the tumor site is challenging, leading to reduced effectiveness and potential adverse effects on normal tissues. The delivery of photosensitizers in conjunction with disulfide linkages has become a major focus in the field of tumor drug delivery.…”

Section: Multifunctional Delivery Carrier Based On Disulfide Bondmentioning

confidence: 99%

Research Progress of Disulfide Bond Based Tumor Microenvironment Targeted Drug Delivery System

Ma,

Wang,

Zhang

et al. 2024

IJN

View full text Add to dashboard Cite

Cancer poses a significant threat to human life and health. Chemotherapy is currently one of the effective cancer treatments, but many chemotherapy drugs have cell toxicity, low solubility, poor stability, a narrow therapeutic window, and unfavorable pharmacokinetic properties. To solve the above problems, target drug delivery to tumor cells, and reduce the side effects of drugs, an anti-tumor drug delivery system based on tumor microenvironment has become a focus of research in recent years. The construction of a reduction-sensitive nanomedicine delivery system based on disulfide bonds has attracted much attention. Disulfide bonds have good reductive responsiveness and can effectively target the high glutathione (GSH) levels in the tumor environment, enabling precise drug delivery. To further enhance targeting and accelerate drug release, disulfide bonds are often combined with pH-responsive nanocarriers and highly expressed ligands in tumor cells to construct drug delivery systems. Disulfide bonds can connect drug molecules and polymer molecules in the drug delivery system, as well as between different drug molecules and carrier molecules. This article summarized the drug delivery systems (DDS) that researchers have constructed in recent years based on disulfide bond drug delivery systems targeting the tumor microenvironment, disulfide bond cleavage-triggering conditions, various drug loading strategies, and carrier design. In this review, we also discuss the controlled release mechanisms and effects of these DDS and further discuss the clinical applicability of delivery systems based on disulfide bonds and the challenges faced in clinical translation.

show abstract

Section: Multifunctional Delivery Carrier Based On Disulfide Bondmentioning

confidence: 99%

Research Progress of Disulfide Bond Based Tumor Microenvironment Targeted Drug Delivery System

Ma,

Wang,

Zhang

et al. 2024

IJN

View full text Add to dashboard Cite

show abstract

NIR light-triggered photodynamic antibacterial nanofiber membrane based on polycaprolactone and phthalocyanine derivative for biomedical applications

Abd El-Aziz,

Serag,

El-Khouly

2024

RSC Adv.

View full text Add to dashboard Cite

show abstract

Advances and Challenges in Immune-Modulatory Biomaterials for Wound Healing Applications

Cao,

Sun,

Qin

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

Wound healing progresses through three distinct stages: inflammation, proliferation, and remodeling. Immune regulation is a central component throughout, crucial for orchestrating inflammatory responses, facilitating tissue repair, and restraining scar tissue formation. Elements such as mitochondria, reactive oxygen species (ROS), macrophages, autophagy, ferroptosis, and cytokines collaboratively shape immune regulation in this healing process. Skin wound dressings, recognized for their ability to augment biomaterials’ immunomodulatory characteristics via antimicrobial, antioxidative, pro- or anti-inflammatory, and tissue-regenerative capacities, have garnered heightened attention. Notwithstanding, a lack of comprehensive research addressing how these dressings attain immunomodulatory properties and the mechanisms thereof persists. Hence, this paper pioneers a systematic review of biomaterials, emphasizing immune regulation and their underlying immunological mechanisms. It begins by highlighting the importance of immune regulation in wound healing and the peculiarities and obstacles faced in skin injury recovery. This segment explores the impact of wound metabolism, infections, systemic illnesses, and local immobilization on the immune response during healing. Subsequently, the review examines a spectrum of biomaterials utilized in skin wound therapy, including hydrogels, aerogels, electrospun nanofiber membranes, collagen scaffolds, microneedles, sponges, and 3D-printed constructs. It elaborates on the immunomodulatory approaches employed by these materials, focusing on mitochondrial and ROS modulation, autophagic processes, ferroptosis, macrophage modulation, and the influence of cytokines on wound healing. Acknowledging the challenge of antibiotic resistance, the paper also summarizes promising plant-based alternatives for biomaterial integration, including curcumin. In its concluding sections, the review charts recent advancements and prospects in biomaterials that accelerate skin wound healing via immune modulation. This includes exploring mitochondrial transplantation materials, biomaterial morphology optimization, metal ion incorporation, electrostimulation-enabled immune response control, and the benefits of composite materials in immune-regulatory wound dressings. The ultimate objective is to establish a theoretical foundation and guide future investigations in the realm of skin wound healing and related materials science disciplines.

show abstract

The Use of Photoactive Polymeric Nanoparticles and Nanofibers to Generate a Photodynamic-Mediated Antimicrobial Effect, with a Special Emphasis on Chronic Wounds

Cited by 3 publications

References 156 publications

Research Progress of Disulfide Bond Based Tumor Microenvironment Targeted Drug Delivery System

Research Progress of Disulfide Bond Based Tumor Microenvironment Targeted Drug Delivery System

NIR light-triggered photodynamic antibacterial nanofiber membrane based on polycaprolactone and phthalocyanine derivative for biomedical applications

Advances and Challenges in Immune-Modulatory Biomaterials for Wound Healing Applications

Contact Info

Product

Resources

About