The use of Pentostam liposomes in the chemotherapy of experimental leishmaniasis

Nanoliposomal artemisinin for the treatment of murine visceral leishmaniasis

“…9,10 Over the past decades, liposomes have demonstrated an increase in the therapeutic efficacy of several drugs. [11][12][13][14][15][16][17][18] Depending upon their physical properties, liposomes are recognized as foreign particles after in vivo administration and are easily cleared by the reticuloendothelial system that harbors Leishmania parasites. [19][20][21] Thus, the association or incorporation of chemotherapeutic agents in liposomes has immense therapeutic benefits against the intracellular infection of Leishmania.…”

Combination Therapy Using Sodium Antimony Gluconate in Stearylamine-Bearing Liposomes against Established and Chronic Leishmania donovani Infection in BALB/c Mice

“…Recently several lipid-based formulations of amphotericin B with reduced levels of toxicity have been used (9,11,32). However, no commercial lipid formulations of SAG are available even though liposome-encapsulated SAG is 200 to 700 times more active than free SAG (2,5,28). In most of these studies the efficacy demonstrated by neutral and negatively charged liposomal formulations of SAG was determined purely on the basis of liver parasite burdens (2,5,21).…”

Antileishmanial Activities of Stearylamine-Bearing Liposomes

“…Although powerful antileishmanial agents, these drugs remain a second line of defense because of their severe toxicities (3). However, the antimonial agents, pentamidine, and amphotericin B, when encapsulated in liposomes, are more effective for the treatment of leishmaniasis and are less toxic than the free drugs (4,6,15). Reduced toxicity and an improved therapeutic index with liposomal formulations, especially of amphotericin B, represent an alternative for the treatment of human visceral leishmaniasis (6,20).…”