“…Although powerful antileishmanial agents, these drugs remain a second line of defense because of their severe toxicities (3). However, the antimonial agents, pentamidine, and amphotericin B, when encapsulated in liposomes, are more effective for the treatment of leishmaniasis and are less toxic than the free drugs (4,6,15). Reduced toxicity and an improved therapeutic index with liposomal formulations, especially of amphotericin B, represent an alternative for the treatment of human visceral leishmaniasis (6,20).…”