The Use of Parenteral Dramamine to Control Postoperative Vomiting: A Report of 1192 Cases

Moore, Daniel C.; Anderson, L.K.; Wheeler, Gordon; Scheidt, John

doi:10.1097/00000542-195207000-00003

Cited by 18 publications

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“…The phenothiazine drugs have been used extensively. Reports have appeared concerning promethazine chlorotheophyllinate (Avomine) (Ashworth, 1952), cyclizine (Marzine) (Moore et al, 1956;Tillman, Wise and Crawford, 1956;Bonica et al, 1958;Bellville, Bross and Howland, 1959), chlorpromazine (Albert and Coakley, 1954;Dripps et al, 1955;Knapp and Beecher, 1956;Burtles and Peckett, 1957), promethazine (Phenergan) (Burtles and Peckett, 1957), dimenhydrinate (Dramamine) (Campbell, 1949;Rubin and Metz-Rubin, 1951;Hume and Wilner, 1952;Moore et al, 1952Moore et al, , 1955Wolfe, 1952;Knapp and Beecher, 1956), diphenhydramine hydrochloride (Benadryl) (Warrington et al, 1953), prochlorperazine maleate (Stemetil; Compazine) (Boyd, 1957;Howat, 1960), and several others. Most of these reports refer to prophylaxis; in those relating to treatment, the indications for therapy are not always well defined, and success is often "more obvious to the statistician than to the patient" (Goodman and Gilman, 1955).…”

Section: Treatment With Drugsmentioning

confidence: 99%

The Cure for Postoperative Vomiting

Parkhouse¹

1963

British Journal of Anaesthesia

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The routine use of drugs to prevent postoperative vomiting is hard to justify. This is not to say, however, that the possibility of vomiting should be given no thought until the patient is actually sick. Postoperative vomiting can be minimized, or prevented entirely, by intelligent ward care. Prevention and cure go hand in hand in the general management of the patient. When vomiting persists the day after operation, a full examination of the patient should be made to exclude a serious cause such as intestinal obstruction, acute dilatation of the stomach, acute gastric ulceration, uraemia, raised intracranial tension, or digitalis intoxication. Cerebral ischaemia is a common cause of nausea, and should always be suspected. Serious vomiting due to the anaesthetic agent is nowadays uncommon, but vomiting due to morphine and other analgesics is common. A general plan for the postoperative management of patients is outlined. If vomiting is troublesome, the phenothiazine drugs are nearly always effective: preferences vary, but perphenazine may be recommended. The new non-phenothiazine drug trimethoxybenzamide (Tigan) shows promise.

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Section: Treatment With Drugsmentioning

confidence: 99%

The Cure for Postoperative Vomiting

Parkhouse¹

1963

British Journal of Anaesthesia

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“…Vo~rriNc during the immediate postoperalave period is a frequent complication of anaesthesia m children Dimenhydrinate, promethazme hydrochloride, and chlorpromazine have all been recommended as effeclave anti-emetic drugs (1,2,3). A comparison o; the chmcal efficacy of these three agents was made with a carefully selected and controlled group of patients.…”

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confidence: 99%

A comparison of the anti-emetic effects of dimenhydrinate, promethazine hydrochloride and chlorpromazine following anaesthesia

Caplin

Smith

1955

Canad Anaes. Soc. J.

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Vo~rriNc during the immediate postoperalave period is a frequent complication of anaesthesia m children Dimenhydrinate, promethazme hydrochloride, and chlorpromazine have all been recommended as effeclave anti-emetic drugs (1, 2, 3). A comparison o; the chmcal efficacy of these three agents was made with a carefully selected and controlled group of patients.A group of patients undergoing operalaon for correction of squint was chosen for this study for the following reasons:1. They were reputed to have a relatively high incidence of post-anaesthetic vomzlang, a prerequisite for ~he demonstratmn of anti-emetic action in a relatively small series of cases 2. There was no operatJve interference with or disease of the gastro-intestinal tract.3. All operations lasted between one-half and one hour. 4. All pataents were on the same ward with the result that observations were made by the same nursing personnel throughout the proleet, 5. All cases were electave and had receaved nothing by mouth for at least four hours prior to induction, ~md had received no solid food since the evening prior to operation.The cases used in the study were drawn from both public and private patients of certain eye-surgeons and were elther treated or placed in the control group on a completely random basis.The first comparison was made between 40 cases treated with dimenhydrinate and 40 untreated controls. Towards the completaon of this series, optimistic reports of the effectiveness of promethazine hydrochlorlde and chlorpromazine prompted us to conduct a second serms consislang ~f 20 cases treated with promethazme hydrochlorlde, 25 casestreated with chlorpromazine and 20 untreated controls.ANAESTHETIC MANAGEMENT All cases were treated lm the following routine manner: 1. All had atropine alone for preoperative medication, and narcotic drugs, alleged to contribute to post-anaesthetic vomiting, were not administered.2. Peroral endotracheal mtubation was performed m all cases following induchon with pentothal sodium and relaxant whenever venepuncture was leasable, or, in smaller children, with ethyl chloride--ether sequence.

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Pharmacology and Toxicology

Harris¹

1953

Archives of Ophthalmology

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The Use of Parenteral Dramamine to Control Postoperative Vomiting: A Report of 1192 Cases

Cited by 18 publications

References 0 publications

The Cure for Postoperative Vomiting

The Cure for Postoperative Vomiting

A comparison of the anti-emetic effects of dimenhydrinate, promethazine hydrochloride and chlorpromazine following anaesthesia

Pharmacology and Toxicology

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