The use of ozone therapy in Buruli ulcer had an excellent outcome

Bertolotti, Antonella; Izzo, Annunziata; Grigolato, Pier Giovanni; Iabichella, Maria Letizia

doi:10.1136/bcr-2012-008249

Cited by 8 publications

(5 citation statements)

References 7 publications

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“…Such properties might potentially accelerate healing of the lesions leading to reductions of ulcer size and ulcer duration. This agreed with previous studies that applied ozone for the treatment of other types of ulcers (such as ulcers involving the stomach, duodenum, veins, and skin) and revealed that ozone was associated with better healing of the ulcers 20 21 22 23 24 25 . However, this contrasts with the findings of previous studies that applied ozone to bone and soft tissues during third molar surgery and found that it did not affect healing time but significantly reduced pain levels 28 30 31 .…”

Section: Discussionsupporting

confidence: 92%

“…The study limitations are that the size of the study sample is small; nevertheless, the sample size in this study is comparable to or even larger than the sample size in previous investigations in this field 15 18 19 20 21 22 23 24 25 . Also, pain assessment in this study depended on subjective reporting of patients’ opinions regarding pain levels.…”

Section: Discussionmentioning

confidence: 80%

“…Ozone has been used for the treatment of ulcers affecting other parts of the gastrointestinal tract202122, blood vessels23 and skin2425; however, none have studied the role of ozone in treatment of recurrent aphthous ulcers in the oral cavity.…”

mentioning

confidence: 99%

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Ozone treatment of recurrent aphthous stomatitis: a double blinded study

AL‐Omiri

Alhijawi

Alzarea

et al. 2016

Sci Rep

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This study aimed to evaluate the use of ozone to treat recurrent aphthous stomatitis (RAS). Consecutive sixty-nine participants with RAS were recruited into this non-randomized double blind, controlled cohort observational study (test group). A control group of 69 RAS patients who matched test group with age and gender was recruited. RAS lesions in test group were exposed to ozone in air for 60 seconds while controls received only air. Ulcer size and pain were recorded for each participant at baseline and daily for 15 days. Ulcer duration was determined by recording the time taken for ulcers to disappear. The main outcome measures were pain due to the ulcer, ulcer size and ulcer duration. 138 RAS participants (69 participants and 69 controls) were analyzed. Ulcer size was reduced starting from the second day in test group and from the fourth day in controls (p ≤ 0.004). Pain levels were reduced starting from the first day in the test group and from the third day in controls (p ≤ 0.001). Ulcer duration, ulcer size after day 2 and pain levels were more reduced in the test group. In conclusion, application of ozone on RAS lesions for 60 seconds reduced pain levels and enhanced ulcers’ healing by reducing ulcers’ size and duration.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 80%

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Ozone treatment of recurrent aphthous stomatitis: a double blinded study

AL‐Omiri

Alhijawi

Alzarea

et al. 2016

Sci Rep

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“…It implies the use of a portable NPWT equipment for outpatients to promote tissue granulation growth and wound blood flow, and which can reduce edema and bacterial growth [ 6 , 85 ]. The application of ozone for the treatment of BU has successfully been tested in Central Africa, involving placing a bag over the lesion and inhaling a combination of O 2 –O 3 with a concentration of 30 g/ml [ 86 ].…”

Section: Health Systems In Africa and Implications For Bu Managementmentioning

confidence: 99%

Buruli ulcer in Africa: Geographical distribution, ecology, risk factors, diagnosis, and indigenous plant treatment options – A comprehensive review

Osei-Owusu,

Aidoo,

Eshun

et al. 2023

Heliyon

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“…When the bag is removed, the wound is covered with a sterile gauze. A case with a skin ulcer in Benin was reported to be healed after the ozone applications in 2 weeks [41]. Compared to surgical treatment, NPWT and ozone therapy are easy to use procedures.…”

Section: Other Suggested Therapiesmentioning

confidence: 99%

Buruli Ulcer in Japan

et al. 2019

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Epidemiology and Bacteriological and Genomic Features of M. ulcerans subsp. shinshuense 1.1 Epidemiology Japan is one of the few countries located in a temperate zone that reports cases of Buruli ulcer (BU). The first case, a 19-year-old female who presented with a chronic and necrotic ulcer on her left elbow, was reported by Mikoshiba et al. in 1982 [1]. This was considered to be an endemic infection due to the lack of a travel history outside the country. A taxonomic study using DNA hybridization assays was later performed on a mycobacterial strain (ATCC 33788) isolated from the skin ulcer lesion of this patient, revealing that this Japanese strain was highly similar to the classical Mycobacterium ulcerans strain ATCC 19423. However, the Japanese strain differed from the previously described M. ulcerans strain in mycolic acid

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The use of ozone therapy in Buruli ulcer had an excellent outcome

Cited by 8 publications

References 7 publications

Ozone treatment of recurrent aphthous stomatitis: a double blinded study

Ozone treatment of recurrent aphthous stomatitis: a double blinded study

Buruli ulcer in Africa: Geographical distribution, ecology, risk factors, diagnosis, and indigenous plant treatment options – A comprehensive review

Buruli Ulcer in Japan

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