“…Electroacupuncture: needles inserted into 8 acupuncture points (TW-5, PC-7, HT-3, PC-3, SI-4, LI-5, LI-10 and LU-5) followed by electrical stimulation(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) mA, 20-40 Hz, continuous wave) -Prefabricated wrist splint: wearing in neutral position for 8 hours each evening BCTQ, DASH Questionnaire, NRS, Semmes-Weinstein monofilament test, Dellon-modified pick-up test, maximal tip pinch strength De Moraes et al 2021 N = 100 (M:F = 17:83), age (mean) = 54.3 years Orthosis group: forearm-palmar orthosis with the wrist immobilized in a neutral position while sleeping Injection group: 6.43 mg (1 ml) of betamethasone dipropionate, 2.63 mg of betamethasone disodium phosphate, and 0.5 ml of 2% lidocaine (xylocaine), totaling 1.5 ml Remission of nocturnal paresthesia, Boston-Levine questionnaire, VAS, complications Golriz et al 2016 N = 24 (M:F = 4:20), age (mean ± sd) = 48.32 ± 12.85 years Orthosis group 1: wrist splint in neutral position (0 degree) Orthosis group 2: neutral wrist splint with an extended trim line to control the metacarpophalangeal joints in 0-10 degrees of flexion DASH Questionnaire, VAS, grip strength, key pinch Lewis et al 2020 N = 105 (M:F = 73:32), age (mean ± sd) = 49 ± 12 years Experimental group: -Education: presentation and booklet regarding CTS pathophysiology, treatment options, posture and activity modification principles -Night splint: neutral wrist orthosis with a custom palmar stay -Home exercises: median nerve-gliding and tendon-gliding exercises Control group: no specific intervention Global rating of change scale, participant satisfaction, BCTQ, DASH Questionnaire, self-report version of the Leeds Assessment of Neuropathic Symptoms and Signs scale, Patient-Specific Functional Scale, symptom distribution, complications Sim et al 2019 N = 41 patients with 56 wrists (M:F = 7:49), age (mean ± sd) = 52.43 ± 12.03 years Splinting only group: a neutral wrist splint applied to the palm of the hand for more than 23 hours daily Combination treatment group: -Orthosis: a neutral wrist splint applied to the palm of the hand for more than 23 hours daily -Supervised exercises: median nerve-gliding and tendon-gliding exercises -Ultrasound therapy: set at a frequency of 1 MHz, intensity of 1.0 W/cm 2 and pulsed mode of 1:4; each session consisted of International Journal of Pain…”