The Use of Omic Technologies Applied to Traditional Chinese Medicine Research

Abstract

Natural products represent one of the most important reservoirs of structural and chemical diversity for the generation of leads in the drug development process. A growing number of researchers have shown interest in the development of drugs based on Chinese herbs. In this review, the use and potential of omic technologies as powerful tools in the modernization of traditional Chinese medicine are discussed. The analytical combination from each omic approach is crucial for understanding the working mechanisms of cells, tissues, organs, and organisms as well as the mechanisms of disease. Gradually, omic approaches have been introduced in every stage of the drug development process to generate high-quality Chinese medicine-based drugs. Finally, the future picture of the use of omic technologies is a promising tool and arena for further improvement in the modernization of traditional Chinese medicine.

Indirubin inhibits cell proliferation, migration, invasion and angiogenesis in tumor-derived endothelial cells

“… 15 TCM is considered a medical system for the prevention and treatment of diseases that focuses on the patient rather than the disease, when compared to the Western medicine. 16 In this study, we focus on indirubin, the major active anti-tumor component of a traditional Chinese herbal medicine used for treatment of chronic myelogenous leukemia. However, there is little research about indirubin’s effects on HCC.…”

From Plant Compounds to Botanicals and Back: A Current Snapshot

“…The current review of Sánchez-Vidaña et al [ 43 ] emphasized how novel advanced technologies in the field of traditional Chinese medicine research are required for the implementation of separation methods, standardization techniques, quality control, the understanding of the action mechanism of single compounds, clinical validation assays; in this order, the application of omic technologies represents a promising approach in phytotherapy [ 38 , 39 , 43 , 44 ].…”

Indirubin inhibits cell proliferation, migration, invasion andangiogenesis in tumor-derived endothelial cells

“…TCM, a complete system of healing developed in ancient China, is receiving more and more attention in China and throughout the world in recent decades [9]. TCM is considered as a medical system for the prevention and treatment of diseases that focuses on the patient rather than the disease when compared to the Western medicine [10]. In this study, we focus on indirubin, the major active anti-tumor component of a traditional Chinese herbal medicine used for treatment of chronic myelogenous leukemia.…”