The Use of NSAIDs in the Postoperative Period: Advantage and Disadvantages

doi:10.15406/jaccoa.2015.03.00107

Cited by 2 publications

(1 citation statement)

References 85 publications

(88 reference statements)

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“…Non-steroidal anti-inflammatory drugs (NSAIDs), such as diclofenac (DFN), are usually prescribed for oral administration in the first few days after these interventions. In addition to their anti-inflammatory action, they also present analgesic and antipyretic properties [ 31 ], acting as inhibitors of the activity of cyclooxygenase enzymes (COX-1 or COX-2), which are involved in the synthesis of key biological mediators of inflammation [ 32 , 33 ]. An ideal drug release system must have predictable release kinetics and maintain an effective drug concentration in the tissues over an appropriate period.…”

Section: Introductionmentioning

confidence: 99%

PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement

Branco

Oliveira

Monteiro

et al. 2022

Gels

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Polyvinyl alcohol (PVA) hydrogels have been widely studied for cartilage replacement due to their biocompatibility, chemical stability, and ability to be modified such that they approximate natural tissue behavior. Additionally, they may also be used with advantages as local drug delivery systems. However, their properties are not yet the most adequate for such applications. This work aimed to develop new PVA-based hydrogels for this purpose, displaying improved tribomechanical properties with the ability to control the release of diclofenac (DFN). Four types of PVA-based hydrogels were prepared via freeze-thawing: PVA, PVA/PAA (by polyacrylic acid (PAA) addition), PVA/PAA+PEG (by polyethylene glycol (PEG) immersion), and PVA/PAA+PEG+A (by annealing). Their morphology, water uptake, mechanical and rheological properties, wettability, friction coefficient, and drug release behavior were accessed. The irritability of the best-performing material was investigated. The results showed that the PAA addition increased the swelling and drug release amount. PEG immersion led to a more compact structure and significantly improved the material’s tribomechanical performance. The annealing treatment led to the material with the most suitable properties: besides presenting a low friction coefficient, it further enhanced the mechanical properties and ensured a controlled DFN release for at least 3 days. Moreover, it did not reveal irritability potential for biological tissues.

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Section: Introductionmentioning

confidence: 99%