The Use of Nonhuman Primates in Evaluating the Safety of Therapeutic Medications Used During Pregnancy

Isoherranen, Nina; Burbacher, Thomas M.

doi:10.1016/b978-012373743-4.50015-1

Cited by 2 publications

(1 citation statement)

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“…Therapeutic agents used during pregnancy and childhood can pose a risk to the developing nervous system by interfering with normal developmental processes [Isoherranen & Burbacher, 2008]. Studies have demonstrated that early exposure to prescription and non-prescription medication can result in adverse treatment effects, ranging from overt congenital dysmorphia to subtle changes in neurobehavioral development over time.…”

Section: Research In Reproductive and Developmental Sciences At The Iprlmentioning

confidence: 99%

Four decades of leading‐edge research in the reproductive and developmental sciences: The Infant Primate Research Laboratory at the University of Washington National Primate Research Center

Burbacher

Grant

Worlein

et al. 2013

American J Primatol

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The Infant Primate Research Laboratory (IPRL) was established in the 1970s at the University of Washington as a visionary project of Dr. Gene (Jim) P. Sackett. Supported by a collaboration between the Washington National Primate Research Center and the Center on Human Health and Disability, the IPRL operates under the principle that learning more about the causes of abnormal development in macaque monkeys will provide important insights into mechanisms underlying childhood neurodevelopmental disorders. Over the past forty years, a broad range of research projects have been conducted at the IPRL. Some have described the normal expression of species-typical behaviors in nursery-reared macaques while others have focused on specific issues in perinatal medicine and research. This article will review the unique history of the IPRL and the scientific contributions produced by research conducted in the laboratory. Past and present investigations at the IPRL have explored the consequences of adverse early rearing, low-birth-weight, prematurity, epilepsy, chemical/drug exposure, viral infection, diarrheal disease, vaccine safety, assisted reproductive technologies and perinatal hypoxia on growth and development. New directions of investigation include the production of a transgenic primate model using our embryonic stem cell-based technology to better understand and treat heritable forms of human mental retardation such as fragile X.

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Section: Research In Reproductive and Developmental Sciences At The Iprlmentioning

confidence: 99%

Four decades of leading‐edge research in the reproductive and developmental sciences: The Infant Primate Research Laboratory at the University of Washington National Primate Research Center

Burbacher

Grant

Worlein

et al. 2013

American J Primatol

Self Cite

View full text Add to dashboard Cite

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Behavioral Approaches for Assessing Nervous System Function during Development in Animal Models

Paule

2010

Developmental Neurotoxicology Research

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The Use of Nonhuman Primates in Evaluating the Safety of Therapeutic Medications Used During Pregnancy

Cited by 2 publications

References 158 publications

Four decades of leading‐edge research in the reproductive and developmental sciences: The Infant Primate Research Laboratory at the University of Washington National Primate Research Center

Four decades of leading‐edge research in the reproductive and developmental sciences: The Infant Primate Research Laboratory at the University of Washington National Primate Research Center

Behavioral Approaches for Assessing Nervous System Function during Development in Animal Models

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