The restriction placed on this article by the last two words of its title indicates at the outset that the material reviewed can shed little light on truly basic neuropharmacology. Nevertheless it cannot be denied that the phenomenologic approach to the study of man's electroencephalogram ( EEG ), when taken in relation to animal experimentation, has contributed much of interest to the correlation between EEG and behavior, especially, of course, where subjective reports are of value.Most of the published work on the effect of drugs on the EEG of man refers only to recordings made from the scalp. No student of electroencephalography who has had the opportunity to record simultaneously from deep systems and the scalp in man will expect to gain insight into brain mechanisms from scalp recordings alone, for much can happen in the depths that has no reflection at the surface.