The use of newly marketed drugs in children and adolescents prescribed in general practice

Wilton, Lynda V.; Pearce, Gillian; Mann, Ronald D.

doi:10.1002/(sici)1099-1557(199904)8:1+<s37::aid-pds400>3.3.co;2-0

Cited by 24 publications

(10 citation statements)

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“…The extent of off-label drug use in children has been documented and is known to be widespread (6), including not only paediatricians but also physicians in general practice (7,8). In clinical practice because new indications or dosing regimens for medications are often accepted long before they are reflected in the labelling (9), referring to the latter is often not helpful in determining the optimal drug regimen for patients, in particular paediatric patients.…”

Section: Discussionmentioning

confidence: 99%

Where physicians look for information on drug prescribing for children

Matsui

Jardine

Steer

et al. 2003

Paediatrics &Amp; Child Health

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BACKGROUND: Despite the important role of drug therapy in children, there is often a lack of readily available information regarding the indications and dosing regimens for medications in paediatrics. OBJECTIVE: To collect data on where family physicians obtain this prescribing information. METHOD: A structured questionnaire was mailed to 500 family physicians in Ontario. RESULTS: Questionnaires were returned by 261 (52%) family physicians, 217 (83%) of whom identified themselves as currently involved in the care of children. Most (87%) reported that the Compendium of Pharmaceuticals and Specialties (CPS) was the source that they most commonly consulted for drug information in children. The available sources of information on prescribing for children were thought to be not adequate by 40% and not readily available by 27%. Sixty-one per cent reported being moderately confident (in doubt part of the time) about their decisions regarding drug prescribing in this age group. The majority (70%) had learned most of what they know about prescribing in paediatrics during practice, while 69% and 62% reported they had little or no teaching during undergraduate and postgraduate (internship or residency) medical education, respectively. CONCLUSIONS: Although it is recognized that for a number of drugs used in children the CPS does not reflect the current standard of care in paediatrics, it is currently the source most commonly referred to by family physicians. Further work should be done in the provision of useful information on paediatric drug therapy to family physicians.

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Section: Discussionmentioning

confidence: 99%

Where physicians look for information on drug prescribing for children

Matsui

Jardine

Steer

et al. 2003

Paediatrics &Amp; Child Health

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“…Four studies evaluated specific subgroups of prescriptions, such as antibiotics or newly marketed medicines, and were therefore excluded [44,62,67,83]. Another study [70] was excluded because it evaluated possible determinants for drug prescriptions to patients below the licensed age.…”

Section: Methodsmentioning

confidence: 99%

A literature review on off-label drug use in children

2005

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“…To our knowledge, only three reports have evaluated unlicensed and off label drug use in office based paediatric practice (private practitioners in non-hospital settings). They all focused on specific aspects of prescriptions: newly marketed drugs,21selective serotonin reuptake inhibitors,22 and children older than 4 years 10. It has been suggested that off label prescribing in office based paediatric care is low, around 10% 10…”

mentioning

confidence: 99%

Off label and unlicensed drug use among French office based paediatricians

Chalumeau¹,

Tréluyer²,

Salanave³

et al. 2000

Archives of Disease in Childhood

154

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Results-A total of 2522 prescriptions were administered to 989 patients; 844 (33%) were used either in an unlicensed (4%) or an oV label (29%) manner. A total of 550 (56%) paediatric patients received one or more oV label prescriptions. Conclusions-OV label prescriptions (that is, outside the terms of the Summary of Product Characteristics) are widespread in oYce based paediatric practice, while unlicensed drug use is rare in our study. New regulations in the licensing process in Europe are needed to allow children to receive drugs that have been fully evaluated in their specific age group. (Arch Dis Child 2000;83:502-505)

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The use of newly marketed drugs in children and adolescents prescribed in general practice

Cited by 24 publications

References 0 publications

Where physicians look for information on drug prescribing for children

Where physicians look for information on drug prescribing for children

A literature review on off-label drug use in children

Off label and unlicensed drug use among French office based paediatricians

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