The use of negative pressure wound therapy (npwt) and dermal substitutes in the treatment of diabetic foot ulcers

Sorrentino, V Padovano; Corte, A Della; Fattopace, A; Campitiello, Ferdinando; Ferretti, Marco; Canonico, Silvestro

doi:10.1186/1471-2318-11-s1-a39

Cited by 3 publications

(2 citation statements)

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“…Negative pressure wound therapy (NPWT) is a revolutionary and innovative wound treatment for various complex wounds. Since its development in the 1990s (1), the therapy is now widely used in clinical treatment with favorable clinical results (2)(3)(4)(5). NPWT promotes wound healing through multiple mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of lncRNA and miRNA expression profiles and ceRNA network construction in negative pressure wound therapy

Wu¹,

Qin²,

Li³

et al. 2021

Ann Transl Med

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Background: This study aims to explore the molecular mechanism of negative pressure wound therapy (NPWT) at the transcriptome level through whole transcriptome sequencing and biometric analysis.Methods: A rat skin defect model was constructed and randomly divided into a NPWT group and a gauze group. The tissue in the center of the wound was used for whole transcriptome sequencing, and differentially expressed messenger RNAs (DEmRNAs), long noncoding RNAs (DElncRNAs), and microRNAs (DEmiRNAs) were identified between the 2 groups. Quantitative real time-polymerase chain reaction (qRT-PCR) analysis was used to verify the sequencing results. Functional enrichment analysis, pathway analysis, and protein-protein interaction (PPI) network analysis of DEmRNAs were conducted. Through bioinformatics analysis, a lncRNA-associated competing endogenous RNA (ceRNA) network was identified and constructed.Results: We detected 896 DEmRNAs, 1,471 DElncRNAs, and 20 DEmiRNAs between the 2 groups.qRT-PCR verified the sequencing results. Functional analysis showed that DEmRNAs were mainly enriched in immune system processes and the Notch signaling pathway. Protein tyrosine phosphatase receptor type C (PTPRC) and signal transducer and activator of transcription 1 (STAT1) were the central hub nodes in the PPI analysis. The ceRNA network contained 11 mRNAs, 15 lncRNAs, and 4 miRNAs. Conclusions:We identified several DEmRNAs, DElncRNAs, and DEmiRNAs between the NPWT treatment group and the control group. These findings may provide new insights into the pathophysiological mechanism of NPWT and wound healing.

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Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of lncRNA and miRNA expression profiles and ceRNA network construction in negative pressure wound therapy

Wu¹,

Qin²,

Li³

et al. 2021

Ann Transl Med

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“…High pressure fluid jet delivered by a hydrosurgery system offers better wound debridement than conventional methods without additional complications, and its use should therefore be encouraged in the elderly [19,20]. Negative pressure wound therapy (NPWT) has an established role in fixing dermal substitutes to acute as well as chronic wounds [21]. The fields of application of NPWT go far beyond: it is particularly useful in the eventuality of abdominal and perineal wound dehiscence, and in patients with entero-cutaneous fistulas.…”

mentioning

confidence: 99%

Technologies and Geriatric Surgery: In Specialty Centres with Patients at the Center

Canonico¹,

Pellino²

2013

J Gerontol Geriatric Res

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Penggunaan Terapi Komplementer dalam Modern Wound Dressing pada Pasien dengan Luka Diabetes: Literature Review

Kusumastuty

Dewi

2020

Holistic Nursing and Health Science

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Introduction: The number of diabetes mellitus sufferers with diabetic ulcus continues to increase. Wound care using conventional methods is no longer effective. Selection of the right wound care can effectively improve wound healing and reduce the financial burden on serving the clientst. The aim of this literature review was to explore the efficacy of wound healing with modern wound care management in diabetic ulcers. Methods: A literature search using the Google Scholar database, Springer Link, Clinical Key, Pubmed and Proquest found 20 journal articles that match the criteria. Results: The majority of research results show the effectiveness of using modern clothing to heal diabetic wounds. Conclusion: Modern wound care dressings with the addition of complementary therapies have shown a more significant effect in accelerating diabetic wound healing.

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The use of negative pressure wound therapy (npwt) and dermal substitutes in the treatment of diabetic foot ulcers

Cited by 3 publications

References 1 publication

Comprehensive analysis of lncRNA and miRNA expression profiles and ceRNA network construction in negative pressure wound therapy

Comprehensive analysis of lncRNA and miRNA expression profiles and ceRNA network construction in negative pressure wound therapy

Technologies and Geriatric Surgery: In Specialty Centres with Patients at the Center

Penggunaan Terapi Komplementer dalam Modern Wound Dressing pada Pasien dengan Luka Diabetes: Literature Review

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