2015
DOI: 10.3109/21691401.2014.998830
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The use of nanoparticles as a promising therapeutic approach in cancer immunotherapy

Abstract: Cancer is one of the most important causes of death all over the world, which has not yet been treated efficiently. Although several therapeutic approaches have been used, some side effects such as toxicity and drug resistance have been observed in patients, particularly with chemotherapy. The nanoparticle-mediated drug delivery systems (DDS) have a great potential to improve cancer treatment by transferring therapeutic factors directly to the tumor site. Such a treatment significantly decreases the adverse ef… Show more

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Cited by 49 publications
(42 citation statements)
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“…Some interventions which promote the immune system of the patient, for example, by vaccination or adjuvant therapy, actively promote antitumor effector mechanisms to improve cancer elimination. On the other hand, administration of specific monoclonal antibodies (mAbs) against different tumor antigens and the adoptive transfer of genetically-modified specific T cells are currently the most rapidly developing approaches for targeted therapy of cancer (Ahmed and Cheung 2013, Brayer and Pinilla-Ibarz 2013, Fenoglio et al 2013, Kvistborg et al 2012, Pranchevicius and Vieira 2013, Hosseini et al 2015, Kazemi et al 2015.…”
Section: Introductionmentioning
confidence: 99%
“…Some interventions which promote the immune system of the patient, for example, by vaccination or adjuvant therapy, actively promote antitumor effector mechanisms to improve cancer elimination. On the other hand, administration of specific monoclonal antibodies (mAbs) against different tumor antigens and the adoptive transfer of genetically-modified specific T cells are currently the most rapidly developing approaches for targeted therapy of cancer (Ahmed and Cheung 2013, Brayer and Pinilla-Ibarz 2013, Fenoglio et al 2013, Kvistborg et al 2012, Pranchevicius and Vieira 2013, Hosseini et al 2015, Kazemi et al 2015.…”
Section: Introductionmentioning
confidence: 99%
“…In attempts to overcome this issue, nanotechnologybased devices are being extensively employed for brain tumor therapy (Benny and Pakneshan 2009, Ferrari 2005, Hosseini et al 2015. These nanovectors have proven successful for targeted drug delivery, and they primarily include nanoparticles, carbon nanotubes (CNTs), microcapsules, without its challenges.…”
Section: Nanotechnology-based Systems For Targeted Delivery To the Brainmentioning
confidence: 99%
“…Although application of CNT was associated with neuroprotective effects in both in vitro (Claire du Toit et al 2007) and in vivo (Yang et al 2010) studies, their use as a drug carrier is limited, which is in part due to their high toxicity. The high toxicity of CNT is related to their geometric structure and impurities, such as residual metal and amorphous carbon (Hosseini et al 2015).…”
Section: Carbon Nanomaterialsmentioning
confidence: 99%
“…It has been shown that nanoparticles (NP) can be used in both the diagnosis and treatment of immunopathologic diseases (Hosseini et al 2015). However, treatment of neurological disorders has usually been associated with several problems, including the blood-brain barrier (BBB) hindrance and a variety of side effects (Jadidi-Niaragh & Mirshafiey 2012).…”
Section: Introductionmentioning
confidence: 99%