The Use of Nano Polymeric Self-Assemblies Based on Novel Amphiphilic Polymers for Oral Hydrophobic Drug Delivery

Hoskins, Clare; Lin, Paul Kong Thoo; Tetley, Laurence; Cheng, Wenguang

doi:10.1007/s11095-011-0602-7

Cited by 16 publications

(4 citation statements)

References 38 publications

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“…To date, there have been only limited in vitro studies on the use of amphiphilic starch nanospheres for improving the bioavailability of hydrophobic drugs . Nanospheres are used as drug carriers to achieve prolonged release of drugs with a specific release.…”

Section: In Vitro Release Studies Of the Nanospheresmentioning

confidence: 99%

Preparation of Rutin‐Loaded Starch Nanospheres

Gao

2017

Starch Stärke

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Rutin‐loaded octenylsuccinic anhydride (OSA)–starch nanospheres are successfully prepared by a dialysis embedding method with self‐assembled modified starch nanospheres as the carrier. The modification of the starch is performed using OSA. The formation and characteristics of the rutin‐loaded OSA–starch nanospheres are studied by scanning electron microscopy (SEM), fluorescence spectroscopy, and dynamic light scattering (DLS). The effects of the degree of substitution (DS) in the OSA–starch, the initial water content, and the rutin concentration on the morphology, particle size, encapsulation efficiency, and drug loading capacity of the nanospheres are evaluated. The SEM images show that the rutin‐loaded OSA–starch nanospheres, with good spherical shape, are larger than regular OSA–starch nanospheres. The drug loading, encapsulation efficiency, and particle size decrease as the degree of substitution or initial water content increases. With an increase of the rutin loading, the drug loading increases, while the encapsulation efficiency and particle size decrease. Rutin is successfully incorporated into the OSA–starch nanospheres. The OSA–starch nanospheres show good sustained release of rutin, providing a theoretical basis for the application of starch nanospheres in the field of medicine.

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Section: In Vitro Release Studies Of the Nanospheresmentioning

confidence: 99%

Preparation of Rutin‐Loaded Starch Nanospheres

Gao

2017

Starch Stärke

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“…Amphiphilic polymers are comprised of hydrophilic and hydrophobic domains which spontaneously aggregate into core-shell nano-aggregates in aqueous environments. Poly(allylamine) grafted amphiphiles have been reported in the solubilisation of lipophilic drug molecules including propofol, prednisolone, griseofulvin (132) and the novel anticancer therapeutic BNIPDaoct (previously discussed) [47]. The formation of a polymer-HNP conjugate resulted in a bifunctional platform that can be used for image guided drug delivery via exploitation of the inherent magnetism possessed by the iron oxide core.…”

Section: Iron Oxide Incorporated Into Supramolecular Systemsmentioning

confidence: 99%

The Use of Iron Oxide Nanoparticles for Pancreatic Cancer Therapy

Hoskins¹

2014

jnmr

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malignant stages, making curative therapy impossible and leading to poor prognosis and incidence equalling mortality [8]. In the year 2000, there were 217,000 new cases of pancreatic cancer with 213,000 deaths worldwide, while in Europe there were 60,139 new patients with 64,801 deaths [9]. In the UK, 7,152 new cases were seen with 7,250 deaths as a result of PDAC [10]. PDAC affects more western/industrialized citizens than other parts of the world. The highest prevalence has been shown among Maoris in native Hawaiians, New Zealand, and Black American societies, while people living in India and Nigeria have the lowest reported morbidity [11,12]. Gemcitabine is the only chemotherapy available clinically for pancreatic cancer treatment. Unfortunately, it proves effective in as few as 23.8% of patients with the only alternative being surgical removal of the localized tumor (Figure 1) [13-15]. Thus, there is huge requirement to increase the efficacy of this treatment as well as exploring alternative therapies. Nanoparticles in Biomedicine Nanoscience and nanotechnology has become a versatile and promising platform for creating novel materials with enhanced properties and potential applications in cancer therapy. Nanotechnology, a wide research field which includes chemistry, engineering, biology and medicine, has excellent potential for early detection, accurate diagnosis, and treatment of cancer [16]. Using materials at nanoscale leads to a "big revolution" in healthcare and medical therapies. Nanoparticles (NPs) are

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“…During the past few decades, amphiphilic polymers (APs) have been intensively studied owing to their ability to self‐assemble into various nanostructures and to mimic biological systems . After incorporation of environmentally sensitive moieties, the hydrophilic‐to‐hydrophobic balance of APs can be readily tuned when exposed to external stimuli, like pH, light, temperature, gas or ionic strength, which facilitates controlling the size, shape, and disassembly behaviors of the self‐assembled APs, enabling a wide‐range of applications like drug delivery, dispersants, emulsifiers, nanoreactors, nanosensors, and biological functional models .…”

Section: Introductionmentioning

confidence: 99%

Controlling CO₂‐Responsive Behaviors of Polymersomes Self‐Assembled by Coumarin‐Containing Star Polymer via Regulating Its Crosslinking Pattern

Yang

Guo

Xia

et al. 2018

Macromol. Rapid Commun.

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An oligo(ethylene glycol)-based star polymer of N -(OEG-C) with fluorescent coumarin as hydrophobic end groups and dual tertiary amines as the star center is designed and synthesized. Owing to its amphiphilic nature of N -(OEG-C) , it will self-assemble into hollow vesicles with coumarin groups dispersed in the hydrophobic membrane and exhibits CO -responsive behavior due to the protonation of amine centers with CO . More importantly, coumarin moieties can either form non-crosslinking with γ-cyclodextrin via the 2/1 host-guest inclusion, or covalently photodimerized by 365 nm light, offering a tunable crosslinking pattern in the hydrophobic membrane and thus adjusting its CO -stimulated reorganization and disassembly behaviors of these vesicles in aqueous solution.

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The Use of Nano Polymeric Self-Assemblies Based on Novel Amphiphilic Polymers for Oral Hydrophobic Drug Delivery

Abstract: Ch(5) and Dansyl(10) showed promising potential as nano-carriers for oral hydrophobic drug delivery.

Cited by 16 publications

References 38 publications

Preparation of Rutin‐Loaded Starch Nanospheres

Preparation of Rutin‐Loaded Starch Nanospheres

The Use of Iron Oxide Nanoparticles for Pancreatic Cancer Therapy

Controlling CO₂‐Responsive Behaviors of Polymersomes Self‐Assembled by Coumarin‐Containing Star Polymer via Regulating Its Crosslinking Pattern

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The Use of Nano Polymeric Self-Assemblies Based on Novel Amphiphilic Polymers for Oral Hydrophobic Drug Delivery

Abstract: Ch(5) and Dansyl(10) showed promising potential as nano-carriers for oral hydrophobic drug delivery.

Cited by 16 publications

References 38 publications

Preparation of Rutin‐Loaded Starch Nanospheres

Preparation of Rutin‐Loaded Starch Nanospheres

The Use of Iron Oxide Nanoparticles for Pancreatic Cancer Therapy

Controlling CO2‐Responsive Behaviors of Polymersomes Self‐Assembled by Coumarin‐Containing Star Polymer via Regulating Its Crosslinking Pattern

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Controlling CO₂‐Responsive Behaviors of Polymersomes Self‐Assembled by Coumarin‐Containing Star Polymer via Regulating Its Crosslinking Pattern