The use of multi-target drugs in the treatment of neurodegenerative diseases

Schyf, Cornelis J. Van der

doi:10.1586/ecp.11.13

Cited by 75 publications

(47 citation statements)

References 54 publications

(58 reference statements)

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“…Target-directed and phenotypic drug discovery screens have been broadly used for drug discovery but in the case of NDs, modulating a single gene target may not always be the best disease model and the active molecules barely have a therapeutic impact, especially for NDs with complex mechanisms [145]. Blocking a single pharmaceutical target with a high-affinity drug is, in theory, the best approach to identifying an effective drug candidate, because it minimizes undesirable side effects.…”

Section: Methodologies Of Screeningmentioning

confidence: 99%

Current Screening Methodologies in Drug Discovery for Selected Human Diseases

et al. 2018

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The increase of many deadly diseases like infections by multidrug-resistant bacteria implies re-inventing the wheel on drug discovery. A better comprehension of the metabolisms and regulation of diseases, the increase in knowledge based on the study of disease-born microorganisms’ genomes, the development of more representative disease models and improvement of techniques, technologies, and computation applied to biology are advances that will foster drug discovery in upcoming years. In this paper, several aspects of current methodologies for drug discovery of antibacterial and antifungals, anti-tropical diseases, antibiofilm and antiquorum sensing, anticancer and neuroprotectors are considered. For drug discovery, two different complementary approaches can be applied: classical pharmacology, also known as phenotypic drug discovery, which is the historical basis of drug discovery, and reverse pharmacology, also designated target-based drug discovery. Screening methods based on phenotypic drug discovery have been used to discover new natural products mainly from terrestrial origin. Examples of the discovery of marine natural products are provided. A section on future trends provides a comprehensive overview on recent advances that will foster the pharmaceutical industry.

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Section: Methodologies Of Screeningmentioning

confidence: 99%

Current Screening Methodologies in Drug Discovery for Selected Human Diseases

et al. 2018

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“…Thus, although there has been significant success in developing novel drugs with the single target paradigm, drug development in chronic diseases has increasingly been challenging. It is becoming clear that chronic diseases involve multiple, dysfunctional pathways that may need simultaneous modulation [1,2]. Most of the targets being modulated by current drugs or drugs in development are downstream of the disease pathway and correlate more with symptoms rather than the cause of the disease.…”

Section: The Challenge In Chronic Disease: Targeting Multiple Target mentioning

confidence: 99%

Botanicals and its extracts: Anew drug discovery and development paradigm for chronic and age-related illnesses

Ilag¹

2018

Med Res Innov

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Advances in medical science have led to the cure and prevention of major diseases leading to longer lifespans. However, increasing lifespan has presented new medical challenges such as the rise of chronic and age-related illnesses. Chronic diseases are often associated with perturbations of multiple disease pathways and may require simultaneous modulation of multiple targets. Thus, the current paradigm of drug discovery and development based on a specific, single disease target may need to be complemented with a holistic systems-based approach. Although botanicals have historically been a source of new drugs, botanical extracts are not widely accepted in Western medicine. A relatively new regulatory approach with botanical extracts as a new class of drugs may pave the way for a new paradigm in discovering and developing therapies for chronic diseases.

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“…341 BNCT is a binary radiation therapy that entails the capture of thermal neutrons by boron-10 ( 10 B) nuclei. The neutron capture event results in the formation of excited, highly cytotoxic 4 2 He + and 7 3 Li + ions ( Figure 35). These high linear energy transfer particles create ionization tracks along their trajectories, which result in irreversible cellular damage and effective cell death.…”

Section: Porphyrin and Expanded Porphyrin Applications For Combinementioning

confidence: 99%

“…There is now a general agreement that molecules which simultaneously recognizing multiple receptors have the potential to be more effective than single target agents. 3,4 Cancer and autoimmune diseases are examples of complex and variable disorders where the detection of one marker cannot be sufficiently conclusive for their reliable diagnosis. Moreover, diagnostic agents with selectivity for several appropriate markers are less sensitive to variations at the level of individual markers.…”

Section: Introductionmentioning

confidence: 99%