The use of MRI for selecting patients with endometrial cancer and significant co-morbidities for vaginal hysterectomy

Freij, Mazen; Saleh, Hanan; Rawlins, Hannah; Duncan, Timothy J.; Nieto, Jo

doi:10.1007/s00404-010-1541-y

Cited by 9 publications

(4 citation statements)

References 17 publications

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“…3D-TVS cannot predict lymph node metastases. Previous studies have reported the sensitivity of MRI to be 46–56% and the specificity to be 88–95% [17,18]. Our study shows that in predicting LNM, the sensitivity, specificity, PPV, NPV, and accuracy of MR were 58%, 96%, 63%, 95%, and 92.43% respectively.…”

Section: Discussionsupporting

confidence: 56%

Magnetic Resonance Imaging (MRI) and Three-Dimensional Transvaginal Ultrasonography Scanning for Preoperative Assessment of High Risk in Women with Endometrial Cancer

Yang

Tian

et al. 2019

Med Sci Monit

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BackgroundTo evaluate the diagnostic performance of MRI and 3D-TVS for assessment of deep myometrial invasion (MI), cervical involvement (CI), and Lymph node metastases (LNM) in endometrial cancer staging before surgery.Material/MethodsFrom January 2016 to December 2017, we reviewed data from 314 women with endometrial cancer who underwent preoperative MRI and 3D-TVS before surgery. The diagnostic sensitivity, specificity, PPV, NPV, and accuracy in detecting MI, CI, and LNM were estimated based on ultimate pathology results.ResultsThe sensitivity, specificity, PPV, NPV, and accuracy of MRI in the diagnosis of MI were 89.19%, 88.97%, 67.35%, 97.99%, and 89.01%, respectively, and the indexes of 3D-TVS for MI were 86.36%, 91.07%, 79.17%, 94.44%, and 89.74%, respectively. The sensitivity, specificity, PPV, NPV, and accuracy of MRI for CI were 75% and 92.35%, 40.9%, 98.13%, and 91.2%, respectively. The indicators of 3D-TVS were 77.78%, 94.29%, 63.63%, 97.06%, and 92.4%, respectively. There were no significant differences in sensitivity, specificity, NPV, and accuracy between MRI and 3D-TVS in the diagnosis of MI and CI. For MI and CI, the sensitivity of combined MRI and 3D-TVS was higher than any other single method (P<0.05). For LNM, the sensitivity, specificity, PPV, NPV, and accuracy of MRI were 58.33%, 96.26%, 63.63%, 95.37%, and 92.43%, respectively.Conclusions3D-TVS is equivalent to MRI in predicting MI and CI. Combined MRI and 3D-TVS can improve the assessment sensitivity, and they are useful in optimizing individualized surgical procedures. The sensitivity of MRI for LNM prediction needs to be improved.

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Section: Discussionsupporting

confidence: 56%

Magnetic Resonance Imaging (MRI) and Three-Dimensional Transvaginal Ultrasonography Scanning for Preoperative Assessment of High Risk in Women with Endometrial Cancer

Yang

Tian

et al. 2019

Med Sci Monit

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“…MRI is recommended for the initial staging and report of endometrial cancer [493][494][495][496] and preoperative pelvic MRI is a moderately sensitive and specific method of identifying invasion to the outer half of myometrium in endometrial cancer [497][498][499]. MRI has a high specificity and negative predictive value in endometrial cancer staging [500]; however, its accuracy in detecting myoinvasion is limited [501]. MRI with DWI and DCE sequences can help establish a correct diagnosis [502,503], while 3.0 T multimodal MRI is an important imaging tool for preoperative endometrial cancer staging [504].…”

Section: Endometrial Cancermentioning

confidence: 99%

Magnetic Fields and Cancer: Epidemiology, Cellular Biology, and Theranostics

Maffei

2022

IJMS

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Humans are exposed to a complex mix of man-made electric and magnetic fields (MFs) at many different frequencies, at home and at work. Epidemiological studies indicate that there is a positive relationship between residential/domestic and occupational exposure to extremely low frequency electromagnetic fields and some types of cancer, although some other studies indicate no relationship. In this review, after an introduction on the MF definition and a description of natural/anthropogenic sources, the epidemiology of residential/domestic and occupational exposure to MFs and cancer is reviewed, with reference to leukemia, brain, and breast cancer. The in vivo and in vitro effects of MFs on cancer are reviewed considering both human and animal cells, with particular reference to the involvement of reactive oxygen species (ROS). MF application on cancer diagnostic and therapy (theranostic) are also reviewed by describing the use of different magnetic resonance imaging (MRI) applications for the detection of several cancers. Finally, the use of magnetic nanoparticles is described in terms of treatment of cancer by nanomedical applications for the precise delivery of anticancer drugs, nanosurgery by magnetomechanic methods, and selective killing of cancer cells by magnetic hyperthermia. The supplementary tables provide quantitative data and methodologies in epidemiological and cell biology studies. Although scientists do not generally agree that there is a cause-effect relationship between exposure to MF and cancer, MFs might not be the direct cause of cancer but may contribute to produce ROS and generate oxidative stress, which could trigger or enhance the expression of oncogenes.

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“…A retrospective cohort study reported that MRI has a high specificity (93%) and NPV (92%) in endometrial cancer staging with reduced sensitivity (56%) of detecting cervical, adnexal, and lymphatic spread. 6 In the evaluation of cervical involvement, Vasconcelos et al 7 reported that the MR sensitivity for cervical extension was 61%, whereas Celik et al 8 reported that the accuracy rate for MRI was 92.2% and for frozen sectioning 95.5%. Recently, some reports have shown that MRI has limited usefulness in endometrial cancers.…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging and Intraoperative Frozen Sectioning for the Evaluation of Risk Factors Associated With Lymph Node Metastasis in Endometrial Cancer

Hahn

Song

Kim

et al. 2013

International Journal of Gynecological Cancer

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The use of MRI for selecting patients with endometrial cancer and significant co-morbidities for vaginal hysterectomy

Cited by 9 publications

References 17 publications

Magnetic Resonance Imaging (MRI) and Three-Dimensional Transvaginal Ultrasonography Scanning for Preoperative Assessment of High Risk in Women with Endometrial Cancer

Magnetic Resonance Imaging (MRI) and Three-Dimensional Transvaginal Ultrasonography Scanning for Preoperative Assessment of High Risk in Women with Endometrial Cancer

Magnetic Fields and Cancer: Epidemiology, Cellular Biology, and Theranostics

Magnetic Resonance Imaging and Intraoperative Frozen Sectioning for the Evaluation of Risk Factors Associated With Lymph Node Metastasis in Endometrial Cancer

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