The use of Mitomycin-C to reduce synechia in middle meatus in sinus surgery: preliminary results

Yamaoka, Wellington Yugo; Gregório, Luiz Carlos

doi:10.5935/1808-8694.20120007

Cited by 11 publications

(23 citation statements)

References 28 publications

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“…Characteristics of the included studies are described in Table . Among 11 trials, 10 were paired designs, in which each patient received two treatments (bilateral sinusitis) and only one trial was a parallel RCT (unilateral sinusitis). Most trials had a percentage of male patients ranged from 47% to 70%.…”

Section: Resultsmentioning

confidence: 99%

“…Mitomycin C or saline solution was applied after endoscopic sinus surgery. The concentrations of Mitomycin C used were 0.4, 0.45, 0.5, 0.8, and 1.0 mg/mL with a volume of 1, 1.5, and 5 mL . The application time ranged from 4 to 5 min.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, Mitomycin C has been used in endoscopic sinus surgery, and some studies have found a benefit in prevention of scar formation whereas other studies did not . The treatment effects across these studies were relatively imprecise because of small sample size.…”

Section: Background and Rationalementioning

confidence: 99%

See 2 more Smart Citations

Efficacy of Mitomycin C for postoperative endoscopic sinus surgery: a systematic review and meta‐analysis

Numthavaj

Tanjararak

Roongpuvapaht

et al. 2013

Clinical Otolaryngology

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Applying Mitomycin C topically after endoscopic sinus surgery could reduce the risk of nasal synechiae and maxillary sinus ostium stenosis in short term by 66% and 74%, respectively. The treatment effects may be more beneficial in patients aged 40 years or younger or in patients without history of revision. However, our results were based on pooling trials with questionable methodological quality. Further trials with good research methodology and long-term follow-up should be conducted to confirm our results.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of Mitomycin C for postoperative endoscopic sinus surgery: a systematic review and meta‐analysis

Numthavaj

Tanjararak

Roongpuvapaht

et al. 2013

Clinical Otolaryngology

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“…Synechia formation between the MT and the lateral nasal wall after ESS and subsequent lateralization of the MT can trigger recurrent CRS. It is thus essential to preserve the mucosa by performing ESS gently . However, mucosal tearing and bone exposure cannot be completely avoided.…”

Section: Discussionmentioning

confidence: 99%

Establishment and verification of a mouse model of nasal wound healing

Joo

Jeon

et al. 2019

The Laryngoscope

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Objectives Poor wound healing as reflected by the development of synechia and osteitis after endoscopic sinus surgery may trigger disease recurrence. Animal models provide insights into the pathogenesis of poor wound healing and may aid in the development of new therapeutics. Here, we established a mouse model of nasal wound healing and confirmed its utility. Study Design Animal study. Methods Unilateral intranasal wounds were induced using a small interdental brush in 6‐week‐old C57BL/6 mice. Forty‐five mice were divided into three groups (each n = 15): one control and two experimental groups (intranasal vs. intraperitoneal dexamethasone). Mice were sacrificed on days 2, 14, and 28 after injury (each n = 5). Serial changes in nasal wound histopathology were described, and intergroup differences were analyzed. Results On day 2, mucosal detachment, hemorrhage, and exudate were observed. On day 14, synechiae featuring neo‐osteogenesis (bone lacunae, osteoblasts, and multinucleated osteoclasts) between the septum and the maxilloturbinate were prominent, followed by wound maturation on day 28: fewer lacunae and smaller osteoblasts. Macrophages were evident only on day 2, and lymphocytes were predominant on day 28. The amount of exudate on day 2 and the synechial area on day 28 were significantly reduced in mice that received dexamethasone systemically compared with control mice, with similar trends in those treated intranasally. Conclusion Our mouse model of nasal wound healing was characterized by the development of bony synechia and neo‐osteogenesis, not soft‐tissue synechia. The model may be useful in the assessment of novel therapeutics to prevent those wounds. Level of Evidence NALaryngoscope, 129:E266–E271, 2019

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“…Alternatively, mitomycin C, an antiproliferative agent with inhibitory effects on fibroblasts, has also been suggested. 26 Mitomycin C has been shown to decrease scar formation in several procedures [27][28][29] and appears to be effective in helping to treat esophageal strictures. 30,31 Vanni et al 13 recently reported the use of mitomycin C in conjunction with TUIAS for treatmentresistant strictures for which prior dilation and TUIAS had failed.…”

Section: Dilationmentioning

confidence: 99%

Postprostatectomy Anastomosis Stenosis: A Systematic Review

Song¹,

Eswara²,

Brandes³

2015

Urology

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The use of Mitomycin-C to reduce synechia in middle meatus in sinus surgery: preliminary results

Abstract: Mitomycin C was not effective in preventing middle meatus synechia, but reduced the probability of total synechia formation.

Cited by 11 publications

References 28 publications

Efficacy of Mitomycin C for postoperative endoscopic sinus surgery: a systematic review and meta‐analysis

Efficacy of Mitomycin C for postoperative endoscopic sinus surgery: a systematic review and meta‐analysis

Establishment and verification of a mouse model of nasal wound healing

Postprostatectomy Anastomosis Stenosis: A Systematic Review

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