The use of mitomycin C in pediatric airway surgery

Gangar, Mona; Bent, John P.

doi:10.1097/moo.0000000000000110

Cited by 8 publications

(2 citation statements)

References 17 publications

(11 reference statements)

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“…[ 12 ] Another study done by Gangar and Bent in 2014 concluded that mitomycin C has been used for the past 16 years to inhibit airway fibroblast proliferation but its benefit remains more hypothetical than proven and its future role remains uncertain. [ 13 ] A study by Madan et al . from a tertiary center in India concluded that mitomycin C is not an effective treatment for postintubation tracheal stenosis.…”

Section: Discussionmentioning

confidence: 99%

Resection and anastomosis for benign tracheal stenosis: Single institution experience of 18 cases

Kumar¹,

Asaf²,

Puri³

et al. 2017

Lung India

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Section: Discussionmentioning

confidence: 99%

Resection and anastomosis for benign tracheal stenosis: Single institution experience of 18 cases

Kumar¹,

Asaf²,

Puri³

et al. 2017

Lung India

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“…These factors include the dose delivered to the tissues (which is concentration dependent), volume, duration of exposure, preparation method, administration, and tissue-related factors (76). Following these observations, the use of MMC was extended to the treatment of laryngeal and tracheal stenosis (77) and then esophageal stricture (78). …”

Section: Treatmentmentioning

confidence: 99%

Anastomotic Strictures after Esophageal Atresia Repair: Incidence, Investigations, and Management, Including Treatment of Refractory and Recurrent Strictures

et al. 2017

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Improved surgical techniques, as well as preoperative and postoperative care, have dramatically changed survival of children with esophageal atresia (EA) over the last decades. Nowadays, we are increasingly seeing EA patients experiencing significant short- and long-term gastrointestinal morbidities. Anastomotic stricture (AS) is the most common complication following operative repair. An esophageal stricture is defined as an intrinsic luminal narrowing in a clinically symptomatic patient, but no symptoms are sensitive or specific enough to diagnose an AS. This review aims to provide a comprehensive view of AS in EA children. Given the lack of evidence-based data, we critically analyzed significant studies on children and adults, including comments on benign strictures with other etiologies. Despite there is no consensus about the goal of the luminal diameter based on the patient’s age, esophageal contrast study, and/or endoscopy are recommended to assess the degree of the narrowing. A high variability in incidence of ASs is reported in literature, depending on different definitions of AS and on a great number of pre-, intra-, and postoperative risk factor influencing the anastomosis outcome. The presence of a long gap between the two esophageal ends, with consequent anastomotic tension, is determinant for stricture formation and its response to treatment. The cornerstone of treatment is endoscopic dilation, whose primary aims are to achieve symptom relief, allow age-appropriate capacity for oral feeding, and reduce the risk of pulmonary aspiration. No clear advantage of either balloon or bougie dilator has been demonstrated; therefore, the choice is based on operator experience and comfort with the equipment. Retrospective evidences suggest that selective dilatations (performed only in symptomatic patients) results in significantly less number of dilatation sessions than routine dilations (performed to prevent symptoms) with equal long-term outcomes. The response to dilation treatment is variable, and some patients may experience recurrent and refractory ASs. Adjunctive treatments have been used, including local injection of steroids, topical application of mitomycin C, and esophageal stenting, but long-term studies are needed to prove their efficacy and safety. Stricture resection or esophageal replacement with an interposition graft remains options for AS refractory to conservative treatments.

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Drug Repurposing for, ENT and Head and Neck, Infectious and Oncologic Diseases: Current Practices and Future Possibilities

Patro

Panda

Sharma

2023

Drug Repurposing for Emerging Infectious Diseases and Cancer

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The use of mitomycin C in pediatric airway surgery

Abstract: Mitomycin C has been used for the past 16 years to inhibit pediatric airway fibroblast proliferation. Its benefit remains more hypothetical than proven and its future role remains uncertain.

Cited by 8 publications

References 17 publications

Resection and anastomosis for benign tracheal stenosis: Single institution experience of 18 cases

Resection and anastomosis for benign tracheal stenosis: Single institution experience of 18 cases

Anastomotic Strictures after Esophageal Atresia Repair: Incidence, Investigations, and Management, Including Treatment of Refractory and Recurrent Strictures

Drug Repurposing for, ENT and Head and Neck, Infectious and Oncologic Diseases: Current Practices and Future Possibilities

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