The Use of Methoteexate in the Treatment of Psoriasis

Hunter, G. A.

doi:10.1111/j.1440-0960.1962.tb01651.x

Cited by 18 publications

(7 citation statements)

References 12 publications

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“…This provides a satisfactory reason for the empirical use of a folic acid antagonist for this condition. Hunter (1962) reported a series of 121 patients with psoriasis treated by oral methotrexate without any serious toxic effects and newer methods of administration of the drug by the intravenous route, as reported by Van Scott (1964) are said to ensure even greater safety.…”

mentioning

confidence: 99%

Pityriasis Rubra Pilaris Treated With Methotrexate

Anderson

1966

Australas J Dermatol

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mentioning

confidence: 99%

Pityriasis Rubra Pilaris Treated With Methotrexate

Anderson

1966

Australas J Dermatol

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“…For the treatment of Psoriasis vulgaris MTX has already been established as a safe and effective therapeutic [ 27 ]. Concerning the treatment of AD only scarce cases series exist.…”

Section: Immunosuppressive Therapymentioning

confidence: 99%

Systemic therapy of atopic dermatitis

Bußmann¹,

Novak²

2017

ALS

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Therapy of severe atopic dermatitis, which is refractory to consistent treatment with topical steroids and topical calcineurin inhibitors is still a problem in many cases. The use of cyclosporine, which is the only approved systemic drug for the therapy of severe atopic dermatitis, is often limited by contraindications or adverse reactions. In this context, results from controlled and open-label studies with novel therapeutic approaches such as methotrexate, omalizumab or rituximab, which are in part very promising, are of great interest. In this work we would like to provide an overview of established and new therapeutic options for the treatment of severe atopic dermatitis.

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“…Later, methotrexate, a more effective and less toxic folic acid antagonist than aminopterin, was used for the treatment of psoriasis using the same logic. [ 15 ]…”

Section: Serendipity In Psoriasis Therapy [ Table 1 mentioning

confidence: 99%

Serendipity and its role in dermatology

Coondoo

Sengupta

2015

Indian J Dermatol

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Serendipity is a pleasant surprise of finding a particularly useful information while not looking for it. Significant historic events occurring as a result of serendipity include the discovery of the law of buoyancy (Archimedes principle) by the Greek mathematician Archimedes, of the Americas by Christopher Columbus and of gravity by Sir Isaac Newton. The role of serendipity in science has been immensely beneficial to mankind. A host of important discoveries in medical science owe their origin to serendipity of which perhaps the most famous is the story of Sir Alexander Fleming and his discovery of Penicillin. In the field of dermatology, serendipity has been responsible for major developments in the therapy of psoriasis, hair disorders, aesthetic dermatology and dermatosurgery. Besides these many other therapeutic modalities in dermatology were born as a result of such happy accidents.

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The Use of Methoteexate in the Treatment of Psoriasis

Cited by 18 publications

References 12 publications

Pityriasis Rubra Pilaris Treated With Methotrexate

Pityriasis Rubra Pilaris Treated With Methotrexate

Systemic therapy of atopic dermatitis

Serendipity and its role in dermatology

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