The Use of Magnetizable Particles in Solid Phase Immunoassay

Pourfarzaneh, M.; Kamel, R. S.; Landon, J.; Dawes, Clive

doi:10.1002/9780470110485.ch6

Cited by 17 publications

(1 citation statement)

References 23 publications

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“…1. Introduction: Superparamagnetic iron oxide nanoparticles are widely used for applications in microchemicals, catalysis, sensors, targeted drug delivery, cell separation and immunoassay [1][2][3][4][5][6][7][8]. Because of these applications, some researches on synthesising the superparamagnetic nanoparticles have been conducted, such as the microlatex method [9,10], the hydrolytic method [11,12], the sol-gel method [13] and the common precipitation method [14].…”

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confidence: 99%

Synthesis of superparamagnetic iron oxide nanoparticles in carbon reduction method

Zhang

Chou

et al. 2013

Micro & Nano Letters

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Owing to the superparamagnetic iron oxide nanoparticles' wide applications, a new approach in the synthesis of mainly superparamagnetic iron oxide nanoparticles is reported. The Fe 3 O 4 nanoparticles (∼500 nm) were synthesised through the carbon reduction method, which is a brand new method. The best parameters of synthesis of the nanoparticles are fixed through characterising by transmission electron microscope (TEM), X-ray diffraction and a vibrating sample magnetometer of the Fe 3 O 4 nanoparticles obtained under different experimental conditions. The TEM characterisation results show that the best ratio of the carbon and ferric chloride is 3:1 and the most suitable heating time is 3 h. The nanoparticles, which were obtained with furnace cooling under vacuum condition after 3 h heating, have the best magnetic properties and most stable crystal from. The characterisations of SiO 2 protected nanoparticles demonstrate that the component of the nanoparticles is Fe 3 O 4. The UV-vis absorption spectrum of the Fe 3 O 4 nanoparticles demonstrates wide-range light absorption of the Fe 3 O 4 nanoparticles. Moreover, quantitative analysis of this new method is conducted to confirm repeatability. The actual qualities of the Fe 3 O 4 nanoparticles are always consistent with the theoretical ones, which indicate that the repeatability of this method is excellent.

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