The Use of Liquid Self-Microemulsifying Drug Delivery Systems Based on Peanut Oil/Tween 80 in the Delivery of Griseofulvin

Ofokansi, KC; Chukwu, K.I.; Ugwuanyi, S. I.

doi:10.1080/03639040802244292

Cited by 21 publications

(4 citation statements)

References 28 publications

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“…Smaller droplets have a greater surface area, which subsequently increases the rate of drug release (Lee et al, 2009;Ofokansi et al, 2009). In addition, most of herbal drug-loaded SEDDS were found to be transparent after dilution with water.…”

Section: Droplet Size Measurementmentioning

confidence: 99%

Self-emulsifying drug delivery system and the applications in herbal drugs

Zhang

et al. 2013

Drug Delivery

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Herbal drugs have been used for thousands of years in the east and have had a recent resurgence in popularity among consumers in the west. However, most of herbal drug are poorly soluble and have hydrophobic properties and poor distribution, leading to reduced bioavailability and hence decreased treatment efficacy, requiring repeated administration or increased dose. In the past few decades, considerable attention has been focused on the development of self-emulsifying drug delivery system (SEDDS) for herbal drugs. SEDDS is isotropic and thermodynamically stable solutions consisting of oil, surfactant, co-surfactant and drug that can spontaneously form oil-in-water micro/nanoemulsion when mixed with water under gentle stirring. The formulation can be a viable alternative to classical formulations to take advantage of their lipophilic nature and to solve their problems of poor solubility, poor bioavailability, low oral absorption and instability. The mechanism of self-emulsification, solubility studies, construction of phase diagram, optimization and characterization of herbal drugs-loaded SEDDS formulation and in situ absorption evaluation of herbal drugs in rat intestine are presented in our article.

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Section: Droplet Size Measurementmentioning

confidence: 99%

Self-emulsifying drug delivery system and the applications in herbal drugs

Zhang

et al. 2013

Drug Delivery

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“…One of the surfactants used for increasing permeation of water into the implant by changing membrane structure, surface tension and permeability is polyethylene glycol sorbitan monooleate (Tween 80 a registered trademark of ICI Americas, Inc.) (Fox, 2009;Ofokansi et al, 2009;Patel and Vavia, 2007;Wang et al,2009), Graves et al (2007) which used Tween 80 as a co-solvent, which increases dissolution rate of an in situ gel formulation into the phosphate buffer solution. Tween 80 is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration.…”

Section: Introductionmentioning

confidence: 98%

Development of an enhanced formulation for delivering sustained release of buprenorphine hydrochloride

Koocheki

Madaeni

Niroomandi³

2011

Saudi Pharmaceutical Journal

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To control the minimum effective dose, and reduce the number and quantity of administered potent drugs are unique features of advanced drug delivery in situ forming gel formulation. The efficacy, consistency, and increasing the application of existing injection therapies can be enhanced through optimization of controlled released systems by using FDA approved biodegradable PLGA (poly-d,l-lactide-co-glycolide) polymer. The purpose of this study was to develop different in situ forming implant (ISFI) formulations of buprenorphine hydrochloride for post treatment of drug addicts, acute and chronic pains. The drug releases from different ISFIs membranes with and without Tween 80 were compared over a period of time. Kinetic equation followed the Korsmeyer-Peppas model, as the plots showed high linearity. The influence of this additive on polymer properties was investigated using differential scanning calorimetry (DSC), and the membranes structure was studied by X-ray diffractometry (XRD) and scanning electron microscope (SEM). Data revealed that Tween 80 modified the drug release pattern using diffusion mechanism and decreased the glass transition temperature (T g) significantly. The degree of crystallinity was decreased after phase inversion which helps the dissolution of drug from membrane. The porosity of modified membranes was in accordance with release profiles. These findings suggest four different in situ forming implant formulations which can release various dose of the buprenorphine hydrochloride in a prolonged time. Also this surfactant can be an attractive additive for modifying the release rate of drugs from PLGA-based membrane drug delivery systems.

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“…The development of self-emulsifying drug delivery systems depends on the use of modified vegetable oils [24], vegetable oils, or semisynthetic medium chain triglycerides with amphiphilic nature [25, 26]. Blending of triglycerides with mono- and diglycerides [27] or with semisynthetic medium chain triglycerides that have amphiphilic character enhances the inherently poor solvent properties of triglycerides.…”

Section: Resultsmentioning

confidence: 99%

Development and Evaluation of Novel Self-Nanoemulsifying Drug Delivery Systems Based on a Homolipid from Capra hircus and Its Admixtures with Melon Oil for the Delivery of Indomethacin

Obitte

Ofokansi

Kenechukwu

2014

Journal of Pharmaceutics

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In this study, goat fat (Capra hircus) and melon oil were extracted and used to formulate self-nanoemulsifying drug delivery systems (SNEDDS) based on either goat fat alone or its admixture with melon oil by employing escalating ratios of oil(s), surfactant blend (1 : 1 Tween 60 and Tween 80), and cosurfactant (Span 85), with or without carbosil, a glidant, for the delivery of indomethacin. The formulations were encapsulated in hard gelatin capsules and then assessed using isotropicity test, aqueous dilution stability and precipitation propensity, absolute drug content, emulsification time, in vitro drug release, and anti-inflammatory activity. The SNEDDS exhibited low precipitation propensity and excellent stability on copious dilution, as well as high drug release in vitro and in vivo. The inhibition produced by the SNEDDS was comparable to that of indomethacin injection (positive control) for much of the 5 h test period, indicating a high degree of bioavailability of the administered SNEDDS. The absolute drug contents and emulsification times fell within narrow limits. This study has shown that a 1 : 1 ratio of melon oil and goat fat could confer favourable properties with respect to drug release and anti-inflammatory activity on SNEDDS for the delivery of indomethacin, thus encouraging further development of the formulations.

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The Use of Liquid Self-Microemulsifying Drug Delivery Systems Based on Peanut Oil/Tween 80 in the Delivery of Griseofulvin

Cited by 21 publications

References 28 publications

Self-emulsifying drug delivery system and the applications in herbal drugs

Self-emulsifying drug delivery system and the applications in herbal drugs

Development of an enhanced formulation for delivering sustained release of buprenorphine hydrochloride

Development and Evaluation of Novel Self-Nanoemulsifying Drug Delivery Systems Based on a Homolipid from Capra hircus and Its Admixtures with Melon Oil for the Delivery of Indomethacin

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