The present article discusses alternative regression models and estimation methods for dealing with multivariate fractional response variables. Both conditional mean models, estimable by nonlinear least squares and quasi-maximum likelihood, and fully parametric models (Dirichlet and Dirichlet-multinomial), estimable by maximum likelihood, are considered.In contrast to previous papers but similarly to the univariate case, a new parameterization is proposed here for the parametric models, which allows the same specification of the conditional mean of interest to be used in all models, irrespective of the specific functional form adopted for it. The text also discusses at some length the specification analysis of fractional regression models, proposing several tests that can be performed through artificial regressions. Finally, an extensive Monte Carlo study evaluates the finite sample properties of most of the estimators and tests considered.JEL classification code: C35.