The Use of Lidocaine Infusion for Analgesia and Prevention of Ileus After Major Abdominal Surgeries

Sholin, I. Yu.; Юрьевич, Шолин Иван; Avetisyan, V. A; А, Аветисян В.; Ezugbaia, B. S.; С, Эзугбая Б.; Zhikharev, V. A.; А, Жихарев В.; Корячкин, В А; А, Корячкин В.; Felker, Evgeny Y.; Ю, Фелькер Е.

doi:10.18821/1993-6508-2018-12-2-107-112

Regional Anesthesia and Acute Pain Management

2018

DOI: 10.18821/1993-6508-2018-12-2-107-112

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The Use of Lidocaine Infusion for Analgesia and Prevention of Ileus After Major Abdominal Surgeries

I. Yu. Sholin¹,

Шолин Иван Юрьевич²,

V. A Avetisyan³

et al.

Abstract: Objective. To assess the effect of infusion of lidocaine solution in patients after extensive abdominal operations. Material and methods. Were examined 42 patients with cancer of the pancreas, which is made pancreatoduodenal resections. The patients were divided into two comparable groups. Patients of the first group (n=21) before surgery injected bolus 1.5 mg/kg lidocaine, followed by infusion at a rate of 1.5 mg/kg*h during the first 24 hours after surgery. Patients of the second group (n=21) started epidura… Show more

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Treatment of acute postoperative pain in patients undergoing open abdominal aortic repair (current state of the problem)

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2022

Regional Anesthesia and Acute Pain Management

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The epidemiology of acute postoperative pain and complications associated with inadequately controlled acute postoperative pain syndrome were considered. The paper presents treatments for acute postoperative pain, the clinical value of multimodal analgesia in enhanced recovery, and reduction of mortality in patients undergoing open abdominal aortic repair. The problem associated with the limitations of the methods in postoperative pain management after open surgical abdominal aortic repair is also considered. The paper also presents alternative methods of multimodal analgesia in patients undergoing other abdominal surgery. The choice of the optimal method in postoperative pain management under the enhanced recovery protocol after open surgical abdominal aortic repair is now significantly limited, as a comparative analysis of alternative methods of analgesia and epidural analgesia in vascular surgery was not conducted. Multicenter studies on multimodal analgesia in postoperative pain management under the enhanced recovery protocol after open surgical abdominal aortic repair are therefore required when deviating from the standard protocol.

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Treatment of acute postoperative pain in patients undergoing open abdominal aortic repair (current state of the problem)

Кожанова

Плотников

2022

Regional Anesthesia and Acute Pain Management

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Comparative evaluation of the perioperative anesthesia methods for cancer patients undergoing pancreaticoduodenectomy

Zakharenkova,

Khoronenko,

Trifanov

2023

Russian Journal of Oncology

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Background. Pancreatoduodenal resections (PDR) are one of the most traumatic and technically complex interventions in abdominal surgery. The correct anesthetic management correct and pain relief allow to substantially reduce the risk of perioperative complications, which remains high even in high-volume oncology centers with extensive experience. Finding new components and methods of anesthesia combined with evaluation of their effectiveness and safety remains actual issue. Aim. To evaluate the efficacy and safety of using intravenous lidocaine infusion as a component of anesthesia and postoperative analgesia in cancer patients during PDR. Material and methods. We analyzed the course of anesthesia, operation and postoperative period of 43 patient (mean age 63.2 ± 7.1 years) undergoing pancreaticoduodenectomy. For the purposes of the study, patients were randomly divided into 2 groups: epidural anesthesia (EA group, n=19) and lidocaine (L group, n=24). For EA group (n=19) we used epidural analgesia as a component of perioperative anesthesia, for L group (n=24) we used prolonged intravenous infusion of lidocaine at an average dose of 1 mg/kg/h. We analyzed the severity of pain syndrome according to NRS in postoperative period, opioid requirement, the time of gastrointestinal function recovery, post-operative complications frequency. In order to prevent systemic toxicity, drug monitoring was carried out - the determination of the plasma concentration of lidocaine. Results. Perioperative opioid requirement was comparable between groups, with no statistically significant differences observed. The degree of pain syndrome according to the NRS scale did not differ statistically, except for the number of NRS scores during activation on day 3, which was significantly lower in the lidocaine group: EA 4.00 (95% CI [3.49 - 4.51] and lidocaine 3, 12 (95% CI [2.64 – 3.61], p = 0.014. In the EA group, there was a statistically significant increase in infusion volume (8.83 ml/kg/h [[(Q1) 7.90 – (Q3) 10 .06] and 7.33 [(Q1) 6.28 - (Q3) 8.49], p = 0.034) and the need for intraoperative vasopressor support than in the lidocaine group (15 (78.9%) and 10 (43 .5%), respectively, p = 0.029. In the lidocaine group, the time to onset of peristalsis was significantly shorter than in the EA group (Me 48.0 h [(Q1) 48.00 - (Q3) 72.00] and Me 60 0 h [(Q1) 36.00 - (Q3) 64.50], p=0.042) The frequency of postoperative complications did not differ between the groups. Conclusions. Based on a comparative analysis of the study results, it can be concluded that prolonged intravenous infusion of lidocaine as a component of perioperative anesthetic protection during pancreatoduodental resections is safe and comparable in terms of analgesic efficacy to epidural blockade.

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The Use of Lidocaine Infusion for Analgesia and Prevention of Ileus After Major Abdominal Surgeries

Cited by 2 publications

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Treatment of acute postoperative pain in patients undergoing open abdominal aortic repair (current state of the problem)

Treatment of acute postoperative pain in patients undergoing open abdominal aortic repair (current state of the problem)

Comparative evaluation of the perioperative anesthesia methods for cancer patients undergoing pancreaticoduodenectomy

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