The use of leukocyte- and platelet-rich fibrin in the management of soft tissue healing and pain in post-extraction sockets: A randomized clinical trial

Mourão, Carlos Fernando de Almeida Barros; Mello-Machado, Rafael Coutinho; Javid, Kayvon; Moraschini, Vittório

doi:10.1016/j.jcms.2020.02.020

Cited by 47 publications

(42 citation statements)

References 25 publications

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“…Concerning the analysis of pain and healing of soft tissue, the present findings are in agreement with previous reports on good outcomes related to the use of L-PRF on extracted dental sockets [5,10,34]. L-PRF implanted in the third molar socket improved postoperative discomfort (p < 0.05) and significantly enhanced soft tissue healing on the seventh and fourteenth day, a timeframe where several other studies also report good clinical results of L-PRF [5,10,34]. Furthermore, the present study provides direct evidence of the connection between released growth factors and clinical improvement by different outcome measures, represented mainly by the strong correlation of PDGF-bb concentration at the L-PRF site with the reduction of pain on the third day after surgery, and the moderate correlation with the cicatrization index at the 7th and the 14th days after surgery.…”

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

“…The primary outcomes (pain and tissue healing) were chosen to calculate the sample size based on the availability of supporting data from the literature. The data from previous studies related to third molars extraction and L-PRF placement [5,10] and a pilot study with 5 patients (included in the present research) shows that a sample size of at least 16 extractions in each group is required to achieve 80% power at a significance level of 5% (α = 0.05) [16]. Therefore, a sample size of 20 extractions for each group was adopted (two extractions per patient, for a total of 20 participants).…”

Section: Sample Calculation and Randomizationmentioning

confidence: 99%

“…Several studies on post-extraction sockets assessing the contribution of L-PRF have shown evaluations that indicated better postoperative and substantial improvements in soft tissue healing and pain reduction, employing tools such as the Landry index for soft tissue repair, and the Visual Analogue Scale (VAS) for pain [4,5,10,11]. These analyses contribute to a qualitative assessment related to the patient's recovery in the postoperative period.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Leukocyte-Platelet-Rich Fibrin (L–PRF) on Pain, Soft Tissue Healing, Growth Factors, and Cytokines after Third Molar Extraction: A Randomized, Split-Mouth, Double-Blinded Clinical Trial

et al. 2021

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This study assessed the effects of leukocyte-platelet-rich fibrin (L–PRF) on soft tissue healing and the correlation with the local concentration of growth factors (GF) and cytokines in the dental socket of lower third molars. Forty lower-third molars (20 participants) were included in this randomized, double-blinded, split-mouth study. After extractions, randomized sides received alveolar filling with L–PRF on one side and a natural blood clot on the other side. The pain was assessed for up to seven days and soft tissue healing (Landry index) for 14 days post-extraction. Swabs were collected from the surgical sites for GF and cytokine assessment by flow luminometry. Participants reported lower postoperative pain on the sides grafted with L–PRF, which also presented increased tissue healing scores (p < 0.05). There were increased levels of all GFs and several cytokines at the L–PRF site at day one, while vascular endothelial growth factor (VEGF), IL–10, and IL1–RA remained higher throughout for seven days (p < 0.05). VEGF concentration at L–PRF sites correlated positively with the participants’ blood platelet content (ρ = 0.769). PDGF correlated negatively with pain experience on days 2 and 3, and positively with soft tissue healing scores, while FGFb presented a weak correlation with a reduction of pain on day 3. The use of L–PRF improves the soft tissue healing process and decreases postoperative pain after the third molar extractions, which correlates with an increase in the local concentration of growth factors such as PDGF and FGFb.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Sample Calculation and Randomizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Leukocyte-Platelet-Rich Fibrin (L–PRF) on Pain, Soft Tissue Healing, Growth Factors, and Cytokines after Third Molar Extraction: A Randomized, Split-Mouth, Double-Blinded Clinical Trial

et al. 2021

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“…Moreover, one does not have to forget the trauma and post‐operative pain after multiple tooth extractions. The use of L‐PRF may reduce patient's discomfort and fasten soft tissue healing (Dragonas et al, 2019; de Almeida Barros Mourão et al, 2020). Moreover, the present study envisaged the possible acceleration of bone healing in the coronal part three months after tooth extraction by using PRF matrices.…”

Section: Discussionmentioning

confidence: 99%

Effect of different platelet‐rich fibrin matrices for ridge preservation in multiple tooth extractions: A split‐mouth randomized controlled clinical trial

Castro

Dessel

Temmerman

et al. 2021

J Clinic Periodontology

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Aim To evaluate dimensional changes in the alveolar ridge and bone structure after tooth extraction when L‐PRF or A‐PRF+ was used in comparison to unassisted socket healing. Materials and methods Twenty patients in need of at least three tooth extractions in the aesthetic zone were included. L‐PRF, A‐PRF+ or control was randomly assigned, leaving one empty socket/edentulous site between conditions. CBCT scans were obtained immediately after tooth extraction and after 3 months of healing. Horizontal and vertical dimensional changes of the ridge and socket fill were calculated. Histological and micro‐CT analysis of bone biopsies were used to evaluate post‐surgical bone structural healing. Results Mean horizontal and vertical changes at 1‐mm below the crest (buccal and palatal side) were similar for the three sites (p > 0.05). For the socket fill, L‐PRF (85.2%) and A‐PRF+ (83.8%) showed superior values than the control (67.9%). The histological and radiological analysis reported more newly formed bone for the PRF groups, without any significant differences between both. Conclusions PRF matrices failed to reduce the dimensional changes after multiple tooth extractions in the premaxilla. After 3‐month healing, both PRF matrices showed radiographically a significant superiority for the socket fill. Histologically, they seemed to accelerate new bone formation.

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Platelet‐Rich Fibrin for Bone Augmentation in Implant Dentistry

2022

Essential Techniques of Alveolar Bone Augmentation in Implant Dentistry

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The use of leukocyte- and platelet-rich fibrin in the management of soft tissue healing and pain in post-extraction sockets: A randomized clinical trial

Cited by 47 publications

References 25 publications

Effects of Leukocyte-Platelet-Rich Fibrin (L–PRF) on Pain, Soft Tissue Healing, Growth Factors, and Cytokines after Third Molar Extraction: A Randomized, Split-Mouth, Double-Blinded Clinical Trial

Effects of Leukocyte-Platelet-Rich Fibrin (L–PRF) on Pain, Soft Tissue Healing, Growth Factors, and Cytokines after Third Molar Extraction: A Randomized, Split-Mouth, Double-Blinded Clinical Trial

Effect of different platelet‐rich fibrin matrices for ridge preservation in multiple tooth extractions: A split‐mouth randomized controlled clinical trial

Platelet‐Rich Fibrin for Bone Augmentation in Implant Dentistry

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