The Use of Leukocyte- and Platelet-Rich Fibrin During Immediate Postextractive Implantation and Loading for the Esthetic Replacement of a Fractured Maxillary Central Incisor

Corso, Marco Del; Mazor, Ziv; Rutkowski, James L.; Ehrenfest, David M. Dohan

doi:10.1563/aaid-joi-d-12-cl.3802

Cited by 40 publications

(27 citation statements)

References 25 publications

(16 reference statements)

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“…The rationale for testing the effect of L-PRF in this clinical situation was based on the natural origin of autogenous processed L-PRF and its potential to promote osteogenesis within the socket due to its dense fibrin mesh and cellular content that could potentially provide a sustained release of growth factors, as well as its potential to act as a physical barrier to avoid soft tissue downgrowth [13, 15]. …”

Section: Discussionmentioning

confidence: 99%

“…A recently published case report has presented promising results in socket and ridge maintenance after tooth extraction by utilizing a leucocyte and platelet-rich fibrin (L-PRF) along with an xenograft as a scaffolding biomaterial between immediate implant and fresh extraction socket wall [15]. Since L-PRF may be engineered to present easily shapeable resilient membrane forms that carry cells that may enhance both hard and soft tissue healing through the sustained release over time of growth factors from active platelets, leukocytes, and other circulating cells, such biomaterial may be presented as an alternative to classic GBR procedures for socket/ridge preservation with or without immediate implant placement [13].…”

Section: Introductionmentioning

confidence: 99%

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The Synergistic Effect of Leukocyte Platelet-Rich Fibrin and Micrometer/Nanometer Surface Texturing on Bone Healing around Immediately Placed Implants: An Experimental Study in Dogs

Neiva

Gil

Tovar

et al. 2016

BioMed Research International

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Aims. This study evaluated the effects of L-PRF presence and implant surface texture on bone healing around immediately placed implants. Methods. The first mandibular molars of 8 beagle dogs were bilaterally extracted, and implants (Blossom™, Intra-Lock International, Boca Raton, FL) were placed in the mesial or distal extraction sockets in an interpolated fashion per animal. Two implant surfaces were distributed per sockets: (1) dual acid-etched (DAE, micrometer scale textured) and (2) micrometer/nanometer scale textured (Ossean™ surface). L-PRF (Intraspin system, Intra-Lock International) was placed in a split-mouth design to fill the macrogap between implant and socket walls on one side of the mandible. The contralateral side received implants without L-PRF. A mixed-model ANOVA (at α = 0.05) evaluated the effect of implant surface, presence of L-PRF, and socket position (mesial or distal), individually or in combination on bone area fraction occupancy (BAFO). Results. BAFO values were significantly higher for the Ossean relative to the DAE surface on the larger mesial socket. The presence of L-PRF resulted in higher BAFO. The Ossean surface and L-PRF presence resulted in significantly higher BAFO. Conclusion. L-PRF and the micro-/nanometer scale textured surface resulted in increased bone formation around immediately placed implants.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Synergistic Effect of Leukocyte Platelet-Rich Fibrin and Micrometer/Nanometer Surface Texturing on Bone Healing around Immediately Placed Implants: An Experimental Study in Dogs

Neiva

Gil

Tovar

et al. 2016

BioMed Research International

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“…The literature showed that PLGA can be used in a number of roles through creative manufacturing and applications. As per the additive regenerative material, L‐PRF membrane have reported efficacy in a wide variety of procedures requiring bone augmentation, including sinus floor augmentation, ridge preservation, and implant therapy (Castro et al, ; Gassling et al, ; Kumar & Shubhashini, ; Temmerman et al, ; Toffler, Holtzclaw, Del Corso, & Ehrenfest, ), with the fibrin network indicating efficacy in regeneration of bone in both in vitro and in situ studies (Al‐Hamed, Tawfik, Abdelfadil, & Al‐Saleh, ; Del Corso, Mazor, Rutkowski, & Dohan Ehrenfest, ; Kumar & Shubhashini, ; Verma, Yadav, Dixit, & Gupta, ), although no efforts have so far been directed toward studying the use of the exudate itself. Analysis of the exudate has revealed that it contains glycoproteins that favor cell adhesion, thereby offering potential to favor the cellular trafficking functions (osteoconduction) crucial to bone regeneration.…”

Section: Discussionmentioning

confidence: 99%

The effect of platelet‐rich fibrin exudate addition to porous poly(lactic‐co‐glycolic acid) scaffold in bone healing: An in vivo study

et al. 2019

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Bone grafting procedures have been widely utilized as the current state‐of‐the‐art for bone regeneration, with autogenous bone graft being the gold‐standard bone reconstructive option. However, the use of autografts may be limited by secondary donor‐site comorbidities, a finite amount of donor supply, increased operating time, and healthcare cost impact. Synthetic materials, or alloplasts, such as the polymeric material, poly(lactic‐co‐glycolic acid) (PLGA) has previously been utilized as a transient scaffold to support healing of bone defects with the potential to locally delivery osteogenic additives. In this study a novel procedure was adopted to incorporate both the dissolved contents and mechanical components of leukocyte‐ and platelet‐rich fibrin (L‐PRF) into an PLGA scaffold through a two‐step method: (a) extraction of the L‐PRF membrane transudate with subsequent immersion of the PLGA scaffold in transudate followed by (b) delivering a fibrin gel as a low‐viscosity component that subsequently polymerizes into a highly viscous, gel‐like biological material within the pores of the PLGA scaffold. Two, ~0.40 cm3, submandibular defects (n = 24) were created per side using rotary instrumentation under continuous irrigation in six sheep. Each site received a PLGA scaffold (Intra‐Lock R&D, Boca Raton, FL), with one positive control (without L‐PRF exudate addition [nL‐PRF]), and one experimental (augmented with PLGA/L‐PRF Blocks [L‐PRF]). Animals were euthanized 6 weeks postoperatively and mandibles retrieved, en bloc, for histological analysis. Histomorphometric evaluation for bone regeneration was evaluated as bone area fraction occupancy (BAFO) within the region of interest of the cortical bone (with specific image analysis software) and data presented as mean values with the corresponding 95% confidence interval values. Qualitative evaluation of nondecalcified histologic sections revealed extensive bone formation for both groups, with substantially more bone regeneration for the L‐PRF induced group relative nL‐PRF group. Quantitative BAFO within the defect as function of the effect of L‐PRF exudate on bone regeneration, demonstrated significantly (p = .018) higher values for the L‐PRF group (38.26% ± 8.5%) relative to the nL‐PRF group (~28% ± 4.0%). This in vivo study indicated that L‐PRF exudate has an impact on the regeneration of bone when incorporated with the PLGA scaffold in a large translational model. Further studies are warranted in order to evaluate the L‐PRF exudate added, as well as exploring the preparation methods, in order to facilitate bone regeneration.

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“…The effect of these membranes on soft tissue healing and maturation is particularly significant[86]. In yet another case report, Del Corso et al[87] in 2012 used L-PRF in immediate implant replacement of maxillary central incisor and reported excellent healing and esthetics. Choukroun et al[88] studied the effect of PRF with (FDBA) freeze-dried bone allograft to augment bone regeneration in direct sinus lifting and found accelerated bone regeneration.…”

Section: Application Of Pc In Periodontics and Implant Dentistrymentioning

confidence: 99%

Evolution, current status and advances in application of platelet concentrate in periodontics and implantology

Agrawal¹

2017

WJCC

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Platelet concentrates (PC) [platelet-rich plasma (PRP) and platelet-rich fibrin (PRF)] are frequently used for surgical procedures in medical and dental fields, particularly in oral and maxillofacial surgery, plastic surgery and sports medicine. The objective of all these technologies is to extract all the elements from a blood sample that could be used to improve healing and promote tissue regeneration. Although leukocyte rich and leukocyte poor PRP’s have their own place in literature, the importance of non-platelet components in a platelet concentrate remains a mystery. PC have come a long way since its first appearance in 1954 to the T-PRF, A-PRF and i-PRF introduced recently. These PC find varied applications successfully in periodontics and implant dentistry as well. However, the technique of preparation, standing time, transfer process, temperature of centrifuge, vibration, etc., are the various factors for the mixed results reported in the literature. Until the introduction of a proper classification of terminologies, the PC were known by different names in different countries and by different commercial companies which also created a lot of confusion. This review intends to clarify all these confusion by briefing the exact evolution of PC, their preparation techniques, recent advances and their various clinical and technical aspects and applications.

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The Use of Leukocyte- and Platelet-Rich Fibrin During Immediate Postextractive Implantation and Loading for the Esthetic Replacement of a Fractured Maxillary Central Incisor

Cited by 40 publications

References 25 publications

The Synergistic Effect of Leukocyte Platelet-Rich Fibrin and Micrometer/Nanometer Surface Texturing on Bone Healing around Immediately Placed Implants: An Experimental Study in Dogs

The Synergistic Effect of Leukocyte Platelet-Rich Fibrin and Micrometer/Nanometer Surface Texturing on Bone Healing around Immediately Placed Implants: An Experimental Study in Dogs

The effect of platelet‐rich fibrin exudate addition to porous poly(lactic‐co‐glycolic acid) scaffold in bone healing: An in vivo study

Evolution, current status and advances in application of platelet concentrate in periodontics and implantology

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