The Use of Intravitreal Ranibizumab to Treat Neovascular Glaucoma Because of Retinal Amyloid Angiopathy in Familial Amyloidosis Transthyretin V30m Related

Beirão, Nuno M.; Miranda, Vasco; Beirão, Idalina; Costa, Paulo; Torres, Pedro

doi:10.1097/icb.0b013e3182681259

Cited by 8 publications

(6 citation statements)

References 11 publications

(8 reference statements)

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“…In fact, there are reports of ATTRv patients presenting with neovascular glaucoma. 30 , 31 The use of panretinal photocoagulation and intravitreal antiVEGF may be used to treat retinal ischemia/neovascularization in ATTRv patients. 30 , 32 Moreover, treatment with panretinal photocoagulation may decrease the endocular production of mutant TTR by the pigmented retinal epithelium.…”

Section: Discussionmentioning

confidence: 99%

“… 30 , 31 The use of panretinal photocoagulation and intravitreal antiVEGF may be used to treat retinal ischemia/neovascularization in ATTRv patients. 30 , 32 Moreover, treatment with panretinal photocoagulation may decrease the endocular production of mutant TTR by the pigmented retinal epithelium. 32 Therefore, patients with retinal angiopathy must be promptly diagnosed and strictly followed.…”

Section: Discussionmentioning

confidence: 99%

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Monitoring the Patient with Retinal Angiopathy Associated with Hereditary Transthyretin Amyloidosis: Current Perspectives

Marques¹,

Coelho²,

Menéres³

et al. 2022

OPTH

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Retinal angiopathy associated with hereditary transthyretin amyloidosis (ATTRv), if untreated, may lead to irreversible vision loss. Our purpose was to systematically review the clinical and imaging features of retinal angiopathy associated with ATTRv and assemble a monitoring approach for these patients. All types of original research studies reporting clinical and imaging findings on retinal angiopathy associated with ATTRv were included. The most common clinical findings were tortuous retinal vessels, microaneurysms, retinal hemorrhages, sheathing of retinal vessels, whitish amyloid deposits along retinal arteries, obliteration of retinal vessels, vitreous hemorrhage, retinal and iris neovascularization. The most relevant imaging findings were hyperautofluorescence of perivessel amyloid deposits; delayed arterial filling, vascular leakage, and retinal ischemia on fluorescein angiography; late hypercyanescence along the choroidal arteries on indocyanine green angiography; perivascular hyperreflective material, needle-shaped deposits on the retinal surface and macular edema on optical coherence tomography (OCT) and attenuated retinal vascular network on OCT-angiography. ATTRv patients should be strictly followed to detect and treat retinal angiopathy, avoiding complications. Both panretinal photocoagulation and intravitreal anti-vascular endothelial growth factor have been used to treat retinal angiopathy in ATTRv. In an individual that presents with retinal angiopathy of unknown etiology, ATTRv should be considered as in the differential diagnosis, even out of the initial core countries. The prognostic value of subclinical findings, namely in OCT-A, is not yet established.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Monitoring the Patient with Retinal Angiopathy Associated with Hereditary Transthyretin Amyloidosis: Current Perspectives

Marques¹,

Coelho²,

Menéres³

et al. 2022

OPTH

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“…С помощью этой процедуры удалось добиться уменьшения нео васкуляризации новообразования и степени болевого синдрома [49]. Применение интрави-треального ранибизумаба в сочетании с лазер-ной коагуляцией сетчатки у пациентов с НВГ, развивающейся на фоне ретинальной амилоидной ангиопатии при семейном амилоидозе, также спо-собствует снижению симптоматики и повышению остроты зрения [4].…”

Section: применение ингибиторов Vegf при неоваскулярной глаукомеunclassified

VEGF inhibitors in glaucoma surgery

Mamikonyan¹,

Petrov²,

Сафонова³

2016

Ophthalmology Reports

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Vascular endothelial growth factor (VEGF) is a signaling protein, that controls vasculogenesis, angiogenesis, vascular support and stimulates permeability of small blood vessels. The following isoforms are presently known: VEGF-A, VEGF-B, VEGF-C, VEGF-В and PGF. VEGF-A, that regulates neoangiogenesis and fibroblast formation, is thought to play the most important role in human organism. Increased expression of VEGF may lead to development and aggravation of pathological conditions including oncology. The article presents a review of preclinical and clinical studies of the main VEGF-inhibitors - bevacizumab and ranibizumab, as well as a brief account on other existing medications of this group. It describes ophthalmological indications for the use of antiangiogenetic agents, as well as the ways of their possible off-label use. The review presents investigations of intravitreal and intracameral injections of VEGF-inhibitors in patients with retinal, chorioidal, iris, and anterior chamber angle neovascularization. It gives examples of successful anti-VEGF use before Ahmed glaucoma valve drainage device implantation and in cases of neovascular glaucoma, induced by radiation therapy for intraocular tumors. Tenon’s capsule’s fibroblasts take part in the process of postoperative wound healing and scarring. According to the latest research, this process could be modulated by angiogenesis inhibitors. This review also recounts the use of anti-angiogenic agents to inhibit postoperative fibroblast proliferation, when used as monotherapy, or as an adjuvant to mitomycin С or 5-fluorouracil. It reviews the research on VEGF-inibitors use in combination with postoperative needling.

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“…Hereditary transthyretin V30M amyloidosis (ATTRV30M) is an autosomal dominant disorder and is a very common form of hereditary amyloidosis caused by extracellular deposition of variants of transthyretin (TTR) in several tissues, including the eye [ 1 , 2 ]. More than 100 amyloidogenic TTR mutations have been documented [ 3 ], but in the Portuguese type, the variant TTR has a substitution of methionine for valine at position 30.…”

Section: Introductionmentioning

confidence: 99%

Anterior Chamber Flare as an Objective and Quantitative Noninvasive Method for Oculopathy in Transthyretin V30M Amyloidosis Patients

Beirão

Miranda

Pinheiro-Torres

et al. 2018

Journal of Ophthalmology

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Purpose Assess the aqueous humor flare in transthyretin V30M amyloidosis patients (ATTRV30M). Materials and Methods This is a retrospective, cross-sectional, noninterventional comparative study including 28 ATTRV30M patients with a unilateral scalloped iris. For comparative analysis, the fellow eye, the nonscalloped iris eye, from each patient was used as control. All patients underwent aqueous humor flare meter and intraocular pressure (IOP) measurements. Results Mean aqueous humor flare was significantly higher in the eyes with the scalloped iris than the control group with the nonscalloped iris (14.1 ± 2.2 versus 6.5 ± 0.9 pc/ms, respectively). No significant differences in IOP were found in the scalloped iris eyes than those in the nonscalloped iris control group (17.1 ± 0.8 versus 16.8 ± 0.7 mmHg, respectively). No significant correlation was not found between the flare and the IOP value within groups. Conclusions In this study, aqueous humor flare values in the scalloped iris eyes may be a valid marker for controlling the stage of the oculopathy in ATTRV30M patients.

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The Use of Intravitreal Ranibizumab to Treat Neovascular Glaucoma Because of Retinal Amyloid Angiopathy in Familial Amyloidosis Transthyretin V30m Related

Abstract: Intravitreal injections of ranibizumab should be evaluated for a potential role on the treatment of amyloid angiopathy neovascular glaucoma. Careful retinal periphery examination should be included in the ophthalmologic examination of all familial amyloidotic polyneuropathy patients.

Cited by 8 publications

References 11 publications

Monitoring the Patient with Retinal Angiopathy Associated with Hereditary Transthyretin Amyloidosis: Current Perspectives

Monitoring the Patient with Retinal Angiopathy Associated with Hereditary Transthyretin Amyloidosis: Current Perspectives

VEGF inhibitors in glaucoma surgery

Anterior Chamber Flare as an Objective and Quantitative Noninvasive Method for Oculopathy in Transthyretin V30M Amyloidosis Patients

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