The use of intrathecal phenol for muscle spasms in multiple sclerosis

Browne, R. A.; Catton, D. V.

doi:10.1007/bf03004977

Cited by 11 publications

(6 citation statements)

References 8 publications

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“…[95][96][97][98] Two case series reported descriptive results in terms of general relief of spasticity (class IV evidence). 95;96 A cross-sectional observational study compared an initial phenol injection (initial group) versus subsequent injections (serial group) in five muscle groups, in both targeted and non-targeted sides, showing a significant reduction in the Ashworth score in both groups.…”

Section: Intrathecal Phenolmentioning

confidence: 99%

“…No randomized controlled trials evaluating the effect of intrathecal phenol on spasticity due to MS or other causes were identified and four observational studies were reviewed. [96][97][98][99] Two case series reported descriptive results in terms of general relief of spasticity (class IV evidence). 96,97 A cross-sectional observational study compared an initial phenol injection (initial group) versus subsequent injections (serial group) in five muscle groups, in both targeted and non-targeted sides, showing a significant reduction in the Ashworth score in both groups 98 (class IV evidence).…”

Section: Intrathecal Phenolmentioning

confidence: 99%

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Pharmacological management of spasticity in multiple sclerosis: Systematic review and consensus paper

et al. 2016

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Section: Intrathecal Phenolmentioning

confidence: 99%

Section: Intrathecal Phenolmentioning

confidence: 99%

Pharmacological management of spasticity in multiple sclerosis: Systematic review and consensus paper

et al. 2016

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“…In the one study which used more explicit outcome measures 78 there appears to have been a marked reduction in adductor spasticity, improved hygiene and improved gait. In the case series of two, 79 one patient was rendered able to sit in a wheelchair (previously unable to) with improved hygiene, while the other was also enabled to sit in a wheelchair, albeit only for 1-2 hours at a time. One case example is cited of a woman who was able to resume sexual relationships after obturator blockade.…”

Section: Summary Of the Direction Of Effect And Impact On Functionmentioning

confidence: 99%

“…Few details are given about the patients included in the studies, or how they were selected, other than that they suffered from spasticity, with the exception of one report of two cases of patients with painful spasms due to longstanding MS. 79 Two of the case series do include case examples, 80,81 but there is no indication that these are typical of all the cases.…”

Section: Populations Examinedmentioning

confidence: 99%

Treatments for spasticity and pain in multiple sclerosis: a systematic review

Beard

Hunn²,

Wight³

2003

Health Technol Assess

236

131

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“…20,[28][29][30][31] Phenol use in children and adults with spasticity is primarily directed toward nerves that have a minimal sensory component and are easily localizable. Successful results have been reported in patients with multiple etiologies, including multiple sclerosis, stroke, torticollis, brain injury, and cerebral palsy.…”

Section: Indicationsmentioning

confidence: 99%

Functional Assessment Following Intrathecal Baclofen Therapy in Children With Spastic Cerebral Palsy

et al. 2003

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The purpose of this article is to describe outcomes of intrathecal baclofen therapy for 29 patients with cerebral palsy, focusing on impairments, functional limitations, and disability. Patients received individualized rehabilitation and were followed up to 24 months. The primary outcome measures were the Ashworth Scale and the functional skills and caregiver assistance scales of the Pediatric Evaluation of Disability Inventory (PEDI). Ashworth Scale scores were significantly reduced (P < or = .0005). All areas of functional skills and caregiver assistance improved. Comparing groups of adults and patients less than 18 years, there were no significant differences, but there was a relationship between age and dose. Comparing groups of patients in high and low levels of independent functional mobility, no significant differences were found. These results provide suggestive evidence that the combination of intrathecal baclofen therapy and rehabilitation has positive effects across the dimensions of disablement. This study serves as a basis for high-level scientific studies of these effects.

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The use of intrathecal phenol for muscle spasms in multiple sclerosis

Cited by 11 publications

References 8 publications

Pharmacological management of spasticity in multiple sclerosis: Systematic review and consensus paper

Pharmacological management of spasticity in multiple sclerosis: Systematic review and consensus paper

Treatments for spasticity and pain in multiple sclerosis: a systematic review

Functional Assessment Following Intrathecal Baclofen Therapy in Children With Spastic Cerebral Palsy

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