The Use of Intramuscular Cefoperazone versus Intramuscular Ceftriaxone in Patients with Nursing Home‐Acquired Pneumonia

Abstract

Intramuscular cefoperazone and intramuscular ceftriaxone are safe and effective in the treatment of nursing home-acquired pneumonia. The clinical outcomes in both treatment groups support their use within this select population without the need for transferring the patient to an acute care hospital. Clinical studies are needed to evaluate the impact of such therapy on the control of health care expenditures within the nursing home facility.

Predictors of mortality for lower respiratory infections in nursing home residents with dementia were validated transnationally

“…For example, mortality from pneumonia or lower respiratory tract infection varies widely in different samples of nursing home residents. In clinical trials excluding severely ill residents, mortality is typically !10% [65][66][67][68], whereas other studies based either in nursing homes or using hospitalized residents have reported between 10% and 40% mortality [11,12,14,[16][17][18]20,22,61,[69][70][71][72][73][74][75][76][77][78][79][80][81]. Different lengths of follow-up account for some of these mortality differences, but large differences in frailty undoubtedly also played a role.…”

Effectiveness of Oral Antibiotic Treatment in Nursing Home‐Acquired Pneumonia

“…Pneumonia, along with other infections, was the leading cause of hospital admissions from nursing homes in a previous study at this institution 5 . Published treatment recommendations and studies in NHAP have generally been limited to issues of parenteral therapy for NHAP, either in the hospital or nursing facility 4,6–8 . Nursing home‐acquired pneumonia is also frequently treated in the NH with oral antibiotics and without extensive evaluation 9–11 .…”

Antibiotic Treatment and Survival of Nursing Home Patients With Lower Respiratory Tract Infection: A Cross-National Analysis

“…17 In a few small trials from the late 1980s or early 1990s, researchers found effectiveness of ceftriaxone or ciprofl oxacin to be equal when compared with similar antibiotics. [18][19][20][21] The ideal study design to test different regimens would be a randomized controlled trial; practical and ethical diffi culties make such a study unlikely. Consequently, we must rely on data from observational studies, attempting to control for differences between treatment groups.…”