The use of Integra dermal regeneration matrix in the 					surgical treatment of a recurrent, extensive malignant skin lesion in the 					temporal region

Halmy, Csaba; Nádai, Zoltán; Csőre, Krisztián; Vajda, Adrienne; Tamás, Róbert

doi:10.1556/oh.2013.29535

Cited by 2 publications

(3 citation statements)

References 15 publications

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“…Integra®, a bi-layered dermal regeneration matrix, has demonstrated considerable success in various reconstructive applications, including complex wounds and soft tissue defects, as well as in cancer resection [14][15][16]. It acts as a scaffold for cellular infiltration, angiogenesis, and the formation of new tissue, ultimately integrating with the surrounding tissue and promoting wound healing.…”

Section: Discussionmentioning

confidence: 99%

Integra® Dermal Regeneration Matrix: A Versatile Solution for Complex Soft Tissue Sarcoma Reconstruction in the Hand

Samargandi¹

2023

Cureus

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This case report describes the successful use of Integra® (Integra LifeSciences Corporation, Plainsboro, New Jersey, United States), an artificial skin substitute, for the reconstruction of soft tissue defects following soft tissue sarcoma resection. We present a case of a 75-year-old female presented with a progressively enlarging lesion on her right hand. Imaging revealed tumor involvement in the extensor tendons and adjacent to the index finger tendon. A percutaneous biopsy confirmed an undifferentiated pleomorphic sarcoma. The patient underwent neoadjuvant radiotherapy followed by wide excision of the tumor. Integra® dermal regeneration matrix was utilized to cover the exposed bone during the surgical procedure. This allowed for wound closure and provided a favorable environment for tissue regeneration and subsequent split-thickness skin graft. Complete wound healing was obtained. Regular follow-up examinations showed no evidence of local recurrence or secondary lesions after one year. The successful use of Integra®, in this case, demonstrates its efficacy as a reconstructive option for complex hand sarcomas. It offers immediate wound coverage and promotes tissue regeneration, thereby avoiding the need for more extensive treatment modalities with associated donor-site morbidity. The utilization of Integra® resulted in high patient satisfaction and excellent recovery. This case highlights the importance of utilizing innovative techniques and materials in achieving optimal outcomes in challenging hand sarcoma reconstructions.

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Section: Discussionmentioning

confidence: 99%

Integra® Dermal Regeneration Matrix: A Versatile Solution for Complex Soft Tissue Sarcoma Reconstruction in the Hand

Samargandi¹

2023

Cureus

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“…We performed the first review of the literature about studies that describe dermal substitutes’ utilisation in reconstruction after skin tumour excision. Table enlists publications available until July 2017 …”

Section: Discussionmentioning

confidence: 99%

“…NMSC present quite high recurrences' rates, and we evaluated their incidence in the studies reviewed. Of them, 25 did not report data about recurrence or did not provide the complete text in English in order to evaluate this aspect . Eleven studies showed no recurrences among their patients, while 6 articles reported cases of recurrence that ranged from 5% to 25% …”

Section: Discussionmentioning

confidence: 99%

Skin cancers and dermal substitutes: Is it safe? Review of the literature and presentation of a 2‐stage surgical protocol for the treatment of non‐melanoma skin cancers of the head in fragile patients

Marcasciano

Mazzocchi

Kaciulyte

et al. 2018

International Wound Journal

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Non-melanoma skin cancers (NMSC) represent the most common skin tumours of the head region. We describe the use of dermal substitute in a 2-stage surgery protocol for selected fragile patients to remove NMSC of the head region. A review of the literature focusing on dermal substitutes' safety after skin tumours excision is provided. A total of 45 fragile patients with NMSC in the head region were selected and scheduled for the 2-stage surgical protocol. The first stage consisted of traditional surgical excision and immediate coverage with Hyalomatrix (Fidia Advanced Biopolymers, Abano Terme, Italy). After histology confirmed diagnosis and clearance of the margins, full-thickness skin autografts were performed. All of the patients reached complete tumour excision and wound healing. No local recurrences were registered during 24 months follow up. The 2-stage surgical therapeutic-diagnostic-reconstructive approach represents a less stressful and oncologically safe surgical protocol in selected fragile patients. When patients cannot tolerate invasive and long surgical procedures, general anaesthesia, and long hospitalisation, skin grafting following temporary skin substitute coverage can achieve oncological clearance and provide good functional and aesthetic results. The use of dermal substitutes represents a valid alternative surgical option in cases of ASA III, fragile patients non-eligible for complex reconstructive surgery. To our knowledge, this is the first paper reviewing literature focusing on dermal substitutes' applications and safety after skin tumour excision.

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The use of Integra dermal regeneration matrix in the surgical treatment of a recurrent, extensive malignant skin lesion in the temporal region

Cited by 2 publications

References 15 publications

Integra® Dermal Regeneration Matrix: A Versatile Solution for Complex Soft Tissue Sarcoma Reconstruction in the Hand

Integra® Dermal Regeneration Matrix: A Versatile Solution for Complex Soft Tissue Sarcoma Reconstruction in the Hand

Skin cancers and dermal substitutes: Is it safe? Review of the literature and presentation of a 2‐stage surgical protocol for the treatment of non‐melanoma skin cancers of the head in fragile patients

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