The use of immunologically competent cells from pig mesenteric lymph nodes to treat pulmonary tumors in mice

Abstract

Summary. Pulmonary tumors were produced in A strain mice by intravenous injecth)n of l x 10

Observations on the effect of radiotherapy, followed by injection of pig lymph node cells, in reducing the number of pulmonary tumors induced by intravenous injection of tumor cells into isogenic mice

“…A previous investigation (Prichard-Thomas and Symes, 1978) had demonstrated that when mouse tumor cells were mixed with tumor-immune pig cells, prior to IV injection into isogenic mice, the resulting number of pulmonary tumors was reduced. Also when tumor-immune pig cell injection was delayed until day 7, an antitumor effect was still obtained if the tumor bearing mice had received local thoracic irradiation on day 3.…”

“…In experiments 1-3 above, nonimmune and tumor-immune pig cells were obtained from the same animal, as described by Prichard-Thomas and Symes (1978). In experiment 4, a similar operative procedure was carried out on a single pig but the proximal node chain was immunized against fragments of a human transitional cell bladder carcinoma, while the distal segment was immunized against mouse tumor B72.…”

Xenogeneic Cellular Immune Responses and the Control of Microscopic Tumor

“…The treatment of a Landschutz ascites tumor using a com bination of radiation and sensitized rat lymphocytes reduced the amount of ascities in the animals and extended their survival when compared to controls [19], Sheep lymphocytes given systemically have in duced regression in established benzpyrene-induced rat sarcomas [20], and in methylcholanthrene-induced rat sarcomas [21], allegedly with some tumor specificity. Most recently, specifically senstized procine lympho cytes have allegedly reduced the number of pulmonary nodules in a lung métastasés model, but only when combined with whole lung radiation [22],…”