The Use of Hyperbaric Oxygen for the Prevention and Management of Osteoradionecrosis of the Jaw: A Dana-Farber/Brigham and Women’s Cancer Center Multidisciplinary Guideline

Sultan, Ahmed S.; Hanna, Glenn J.; Margalit, Danielle N.; Chau, Nicole G.; Goguen, Laura A.; Marty, Francisco M.; Rabinowits, Guilherme; Schoenfeld, Jonathan D.; Sonis, Stephen T.; Thomas, Tom; Tishler, Roy B.; Treister, Nathaniel S.; Villa, Alessandro; Woo, Sook‐Bin; Haddad, Robert I.; Mawardi, Hani

doi:10.1634/theoncologist.2016-0298

Cited by 68 publications

(59 citation statements)

References 41 publications

(92 reference statements)

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“…Therefore, during this period, we kept monitoring blood glucose levels without additional work. Nonetheless, the protocol of establishing a STZ-induced diabetic rat model has been widely applied in the wound healing studies of diabetic foot ulcers, as supported by the following references (Table S1) [10][11][12][13][14][15][16][17]. Then, a wound (5 × 5 mm) was created in the left forepaw of each rat after anesthetizing with sodium pentobarbital (45 mg/kg body weight) by intraperitoneal injection.…”

Section: Animal Modelmentioning

confidence: 99%

“…Hypoxia is a key inhibiting factor for wound healing of DFUs, which can block fibroblast proliferation, collagen production, and capillary angiogenesis and enhance the risk of infection [8][9][10]. Hyperbaric oxygen therapy (HBOT) is the most commonly utilized adjunctive therapy for improving wound tissue hypoxia in DFU treatment [11][12][13], but this method has not achieved universal success in many studies and is costly [14,15]. And the production of HBO-related oxidative stress is a concern [16].…”

Section: Introductionmentioning

confidence: 99%

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Improved Healing of Diabetic Foot Ulcer upon Oxygenation Therapeutics through Oxygen-Loading Nanoperfluorocarbon Triggered by Radial Extracorporeal Shock Wave

Wang

Yin

Han

et al. 2019

Oxidative Medicine and Cellular Longevity

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Diabetic foot ulcers (DFUs), the most serious complication of diabetes mellitus, can induce high morbidity, the need to amputate lower extremities, and even death. Although many adjunctive strategies have been applied for the treatment of DFUs, the low treatment efficiency, potential side effects, and high cost are still huge challenges. Recently, nanomaterial-based drug delivery systems (NDDSs) have achieved targeted drug delivery and controlled drug release, offering great promises in various therapeutics for diverse disorders. Additionally, the radial extracorporeal shock wave (rESW) has been shown to function as a robust trigger source for the NDDS to release its contents, as the rESW harbors a potent capability in generating pressure waves and in creating the cavitation effect. Here, we explored the performance of oxygen-loaded nanoperfluorocarbon (Nano-PFC) combined with the rESW as a treatment for DFUs. Prior to in vivo assessment, we first demonstrated the high oxygen affinity in vitro and great biocompatibility of Nano-PFC. Moreover, the rESW-responsive oxygen release behavior from oxygen-saturated Nano-PFC was also successfully verified in vitro and in vivo. Importantly, the wound healing of DFUs was significantly accelerated due to improved blood microcirculation, which was a result of rESW therapy (rESWT), and the targeted release of oxygen into the wound from oxygen-loaded Nano-PFC, which was triggered by the rESW. Collectively, the oxygen-saturated Nano-PFC and rESW provide a completely new approach to treat DFUs, and this study highlights the advantages of combining nanotechnology with rESW in therapeutics.

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Section: Animal Modelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Improved Healing of Diabetic Foot Ulcer upon Oxygenation Therapeutics through Oxygen-Loading Nanoperfluorocarbon Triggered by Radial Extracorporeal Shock Wave

Wang

Yin

Han

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…The Division of Head and Neck Oncology of Dana-Farber/Brigham and Women’s Cancer Center, USA does not recommend the routine use of hyberbaric oxygen therapy for the prevention or management of osteoradionecrosis and they recommend adjunctive hyberbaric oxygen therapy in exceptionally high risk cases where there is failed history of conservative therapy and subsequent surgical resection. 6 …”

mentioning

confidence: 99%

Clinical utility of hyperbaric oxygen therapy in dentistry

Shamim¹

2018

Med Gas Res

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“…Some reports have recommended clodronate for ORN owing to its effect on osteoclast inhibition, but evidence supporting its usefulness is insufficient [6]. In addition, hyperbaric oxygen therapy was reported to be an excellent adjunct treatment for ORN, as it stimulated angiogenesis, fibroblast, and collagen formation [20]. Khorsandi also reported that hyperbaric oxygen therapy is associated with significantly improved clinical and radiographic outcomes for a patient with cervical ORN [11].…”

Section: Discussionmentioning

confidence: 99%

Lumbar vertebral osteoradionecrosis: a rare case report with 10-year follow-up and brief literature review

Cong

Xie

Liang

et al. 2020

BMC Musculoskelet Disord

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Background: Osteoradionecrosis (ORN) is a complication that occurs after radiotherapy for head or neck malignancies. ORN of the spine is rare, with only few cases affecting the cervical spine reported to date. To our knowledge, no case of lumbar ORN has been reported. We report a rare case of ORN in the lumbar spine that occurred 2 years after radiotherapy and perform a literature review. Case presentation: We present a case of lumbar ORN that occurred 2 years after radiotherapy for gallbladder carcinoma. The patient was successfully treated conservatively and followed up for > 10 years. Conclusions: ORN of the spine is a rare complication of radiotherapy. Spinal ORN is clinically described as a chronic disease with a slow onset. The most common presenting symptom of spinal ORN is pain. However, as ORN progresses, spinal kyphosis and instability can lead to neurological compression and thus to induced myelopathy or radiculopathy. Treatment of spinal ORN is comprehensive, including orthosis, medication, hyperbaric oxygen therapy, surgery, and new treatment combinations of pentoxifylline and tocopherol. The surgical rate for spinal ORN is relatively high.

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The Use of Hyperbaric Oxygen for the Prevention and Management of Osteoradionecrosis of the Jaw: A Dana-Farber/Brigham and Women’s Cancer Center Multidisciplinary Guideline

Cited by 68 publications

References 41 publications

Improved Healing of Diabetic Foot Ulcer upon Oxygenation Therapeutics through Oxygen-Loading Nanoperfluorocarbon Triggered by Radial Extracorporeal Shock Wave

Improved Healing of Diabetic Foot Ulcer upon Oxygenation Therapeutics through Oxygen-Loading Nanoperfluorocarbon Triggered by Radial Extracorporeal Shock Wave

Clinical utility of hyperbaric oxygen therapy in dentistry

Lumbar vertebral osteoradionecrosis: a rare case report with 10-year follow-up and brief literature review

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