The use of hydroxyapatite toothpaste to prevent dental caries

O'Hagan-Wong, Kelsey; Enax, Joachim; Meyer, Frederic; Ganß, Bernhard

doi:10.1007/s10266-021-00675-4

Cited by 55 publications

(54 citation statements)

References 65 publications

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“…Dental caries are caused by the progression of demineralization due to acid contact with the hydroxyapatite in tooth enamel, but if the acid resistance of the tooth surface can be improved, the progression of demineralization can be inhibited and dental caries can be prevented [ 1 , 2 ]. Recently, prophylactic treatments aimed at improving the acid resistance of teeth, such as the application of casein phosphopeptide (CPP) to the tooth surface and the incorporation of nanoapatite into the toothpaste, have been investigated [ 3 , 4 , 5 ]. In addition, new caries-prevention methods involving various approaches are being developed, such as the use of bioactive peptides to inhibit Streptococcus mutans biofilm formation and bacterial attachment to tooth surfaces [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Enamel Acid Resistance and Whitening Effect of the CAP System

Miki¹,

Miake

Shimoda

et al. 2022

Dentistry Journal

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This study aimed to compare the effectiveness of a novel professional tooth-strengthening system and a conventional caries-prevention method that involved the use of high fluoride concentrations, to determine whether the system has a whitening effect. Bovine tooth-enamel samples were treated with fluoride gel (conventional APF method) or a mixture of citric acid gel, calcium phosphate (α-TCP), and fluoride gel, referred to as the CAP system; these treatments were performed to generate an acid-resistant layer on the enamel surface. For the evaluation of the acid resistance, a cyclic experiment, involving a 1-h remineralization and a 24-h acid treatment, was conducted thrice after the treatments. The height profiles were observed using a 3D-measuring laser microscope and the hardness was evaluated by Vickers hardness test. The morphological changes in the surface and cross-section of the enamel were observed by scanning electron microscopy. To evaluate the whitening effect, the enamel was ground until the color of the underlying dentin was recognizable; the CAP system was applied once, and the color change was measured using a color difference meter. As a result, it was confirmed that an acid-resistant layer was formed on the tooth surfaces treated with the CAP system, and a whitening effect was obtained.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Enamel Acid Resistance and Whitening Effect of the CAP System

Miki¹,

Miake

Shimoda

et al. 2022

Dentistry Journal

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“…Hydroxyapatite (HAp) is known as one of the most abundant materials on earth, which composes a significant fraction of animals’ bones, fish, shells, and some minerals (e.g., limestone) [ 1 ]. HAp is extensively utilized in many industries, including artificial bones [ 2 ], biocomposites [ 3 ], toothpaste [ 4 ], and coatings [ 5 ]. In recent decades, HAp has also been an efficient and low-cost material for heterogeneous catalysis, which can even be extracted from biowastes [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

In Situ Formation of Copper Phosphate on Hydroxyapatite for Wastewater Treatment

et al. 2022

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Here, we control the surface activity of hydroxyapatite (HAp) in wastewater treatment which undergoes peroxodisulfate (PDS) activation. Loading the catalytically active Cu species on HAp forms a copper phosphate in the outer layer of HAp. This modification turns a low active HAp into a high catalytically active catalyst in the dye degradation process. The optimal operational conditions were established to be [Cu–THAp]0 = 1 g/L, [RhB]0 = 20 mg/L, [PDS]0 = 7.5 mmol/L, and pH = 3. The experiments indicate that the simultaneous presence of Cu-THAp and PDS synergistically affect the degradation process. Additionally, chemical and structural characterizations proved the stability and effectiveness of Cu-THAp. Therefore, this work introduces a simple approach to water purification through green and sustainable HAp-based materials.

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“…As acid-soluble mineral, it is subjected to erosion by the attack of acidic agents, including caries [ 14 ]. To increase tooth remineralization and to minimize demineralization, products based on fluorides and/or calcium phosphates are used [ 3 , 15 , 16 , 17 , 18 , 19 ]. Of all remineralization agents, fluoride is most commonly applied [ 1 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…It is used in different products, e.g., in mouthwashes [ 20 ], toothpastes [ 15 ], gels [ 21 ], and varnishes [ 22 ] in varying concentrations for caries prevention [ 23 ]. Fluoride-free prophylactic systems for dental care involve mainly calcium phosphate-based formulations where calcium phosphate is applied to improve and restore the quality of the inorganic tooth mineral [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Incorporation of Fluoride into Human Teeth after Immersion in Fluoride-Containing Solutions

2022

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Toothpastes and mouth rinses contain fluoride as a protective agent against caries. The aim of this study was to determine the degree of fluoride-uptake by human tooth mineral during immersion into fluoride-containing aqueous solutions as different pH. Human teeth were immersed in fluoride-containing solutions to assess the extent of fluoride incorporation into tooth enamel. A total of 16 extracted teeth from 11 patients were immersed at 37 °C for one minute into aqueous fluoride solutions (potassium fluoride; KF) containing either 250 ppm or 18,998 ppm fluoride (1-molar). Fluoride was dissolved either in pure water (neutral pH) or in a citrate buffer (pH 4.6 to 4.7). The elemental surface composition of each tooth was studied by energy-dispersive X-ray spectroscopy in combination with scanning electron microscopy and X-ray powder diffraction. The as-received teeth contained 0.17 ± 0.16 wt% fluoride on average. There was no significant increase in the fluoride content after immersion in 250 ppm fluoride solution at neutral or acidic pH values. In contrast, a treatment with a 1-molar fluoride solution led to significantly increased fluoride concentrations by 0.68 wt% in water and 9.06 wt% at pH 4.7. Although such fluoride concentrations are far above those used in mouth rinses or toothpastes, this indicates that fluoride can indeed enter the tooth surface, especially at a low pH where a dynamic dissolution-reprecipitation process may occur. However, precipitations of calcium fluoride (globuli) were detected in no cases.

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The use of hydroxyapatite toothpaste to prevent dental caries

Cited by 55 publications

References 65 publications

Evaluation of Enamel Acid Resistance and Whitening Effect of the CAP System

Evaluation of Enamel Acid Resistance and Whitening Effect of the CAP System

In Situ Formation of Copper Phosphate on Hydroxyapatite for Wastewater Treatment

Incorporation of Fluoride into Human Teeth after Immersion in Fluoride-Containing Solutions

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