The Use of Hyaluronidase to Treat the Excess of Cross-Linked Hyaluronic Acid Following Aesthetic Medicine Procedures: A Practical Point of View

Ranneva, Evgenyia

doi:10.4172/2165-7548.1000357

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…Our recorded cases of abuse, especially those with puffiness of the cheeks, bags under the eyes, and swollen lips were treated with hyaluronidase injection. Hyaluronidase is effective to treat the overcorrection, but it may trigger allergies after its use, thereby, the therapist must do allergic skin testing before giving this enzyme to avoid the risk of allergy and/or angioedema [14] [15].…”

Section: Discussionmentioning

confidence: 99%

The Abuse of Dermal Fillers: A Clinico-Epidemiological Study of 35 Cases

Hamzawi¹,

Baaj²

2019

JCDSA

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Background: Nowadays, the use of dermal fillers for correcting signs of aging, such as wrinkles, depressions, and folds, has become increasingly popular. However, the abuse of these products can lead to disfigurements and unpredictable consequences among users. Objective: To evaluate the clinical abnormalities related to dermal fillers abuse in Iraqi people, and identify the various factors contributing to them. Methods: A total of 35 patients with different facial abnormalities due to the abuse of dermal fillers, attending our clinic in Diwaniyah, Iraq, from September 2016 to December 2017, were enrolled. A questionnaire-based analysis was used to collect clinical and sociodemographic data from patients to determine the etiological profile behind this problem. Several disfigurements and facial defects were diagnosed on clinical base. We have treated most of the situations that require intervention and treatment. Results: A total of 35 patients aged between 25 and 54 years with a sex ratio of 0.093 were enrolled in this study. Their mean age was 42 years, and the age group between 35 and 45 years was forming 85.7% of the cases. The clinical abnormalities recorded in this study include: buffy face 8 (22.8%), facial asymmetry 3 (8.5%), Mdoka fish lips like 6 (17%), periorbital redness 1 (2.8%), filler fatigue 6 (17%), bags under eyes 4 (11.4%), sizeable bulbous nose 4 (11.4%), topographical changes 2 (5.7%), and stone-like cheeks 1 (2.8%). The leading causes for the abuse of fillers were as follows: 12 (34.28%) candidates were not compatible with the procedure, 9 (25.7%) were non-compliance with the indications of the Food and Drug Organization (FDA), 9 (25.7%) fillers were injected in the wrong place, 18 (51.4%) injections were of a larger quantity than required, and 5 (14.2%) had frequent and long-term injection. Conclusion: The use of dermal fillers for a wrong purpose can result in disfigurements rather than beautification. The commonest disfigurements are the puffy face, enlarged lips, and bags under eyes.

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Section: Discussionmentioning

confidence: 99%

The Abuse of Dermal Fillers: A Clinico-Epidemiological Study of 35 Cases

Hamzawi¹,

Baaj²

2019

JCDSA

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“…MeCHa‐ and MePHa‐Gels are enzymatically degradable by hyaluronidase enzyme, hydrolyzing the bonds between N‐acetyl‐D‐glucosamine and D‐glucuronic acid. [ 29 ] MePGa‐Gels are also enzymatically degradable by collagenase enzyme breaking the peptide bonds in the backbone of the chain. MePGa‐Gels degrade faster than MeCHa‐ and MePHa‐Gels at the same enzyme concentration and under the same test conditions (Figure S5a, Supporting Information).…”

Section: Figurementioning

confidence: 99%

An Intrinsically‐Adhesive Family of Injectable and Photo‐Curable Hydrogels with Functional Physicochemical Performance for Regenerative Medicine

Karami

Nasrollahzadeh

Wyss

et al. 2021

Macromol. Rapid Commun.

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Intrinsically adhesive hydrogels have various functions in biomedical areas particularly in minimally-invasive surgical treatments. [1,2] In these medical situations, bioadhesives have to present not only strong adhesion to wet tissues but specific ranges of injectability, degradability, swelling, biocompatibility, and mechanical match. [3,4] This is particularly challenging as the adhesive mechanism of the hydrogel should also allow proper material functionality in its bulk. The adhesion of hydrogels could be enhanced by strong bonds with the tissue as well as the material's capacity to dissipate energy. [5,6] Dissipative double-network hydrogels show high adhesion when either the tissue or the hydrogel substrate is chemically treated, so that the interfacial bonds can be created. However, it is difficult to use these adhesive systems in minimally-invasive biomedical situations, in which hydrogel must be injected and formed in situ and tissue treatment would impose serious limitations. In Attaching hydrogels to soft internal tissues is crucial for the development of various biomedical devices. Tough sticky hydrogel patches present high adhesion, yet with lack of injectability and the need for treatment of contacting surface. On the contrary, injectable and photo-curable hydrogels are highly attractive owing to their ease of use, flexibility of filling any shape, and their minimally invasive character, compared to their conventional preformed counterparts. Despite recent advances in material developments, a hydrogel that exhibits both proper injectability and sufficient intrinsic adhesion is yet to be demonstrated. Herein, a paradigm shift is proposed toward the design of intrinsically adhesive networks for injectable and photo-curable hydrogels. The bioinspired design strategy not only provides strong adhesive contact, but also results in a wide window of physicochemical properties. The adhesive networks are based on a family of polymeric backbones where chains are modified to be intrinsically adhesive to host tissue and simultaneously form a hydrogel network via a hybrid cross-linking mechanism. With this strategy, adhesion is achieved through a controlled synergy between the interfacial chemistry and bulk mechanical properties. The functionalities of the bioadhesives are demonstrated for various applications, such as tissue adhesives, surgical sealants, or injectable scaffolds.

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The Use of Hyaluronidase to Treat the Excess of Cross-Linked Hyaluronic Acid Following Aesthetic Medicine Procedures: A Practical Point of View

Cited by 2 publications

References 7 publications

The Abuse of Dermal Fillers: A Clinico-Epidemiological Study of 35 Cases

The Abuse of Dermal Fillers: A Clinico-Epidemiological Study of 35 Cases

An Intrinsically‐Adhesive Family of Injectable and Photo‐Curable Hydrogels with Functional Physicochemical Performance for Regenerative Medicine

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