The use of high-dose-rate brachytherapy alone after lumpectomy in patients with early-stage breast cancer treated with breast-conserving therapy

Full-Dose Intraoperative Radiotherapy with Electrons in Breast Cancer

“…According to this important observation, irradiation of the whole mammary gland could be avoided in select patients and adjuvant radiotherapy could be limited to the sterilization of residual cancer in the immediate vicinity of the tumor bed. The feasibility of partial-breast irradiation (PBI) has been investigated by several authors, using different techniques, such as brachytherapy with multicatheter [1,2,4,13,15,20,22,23,34,36] or single-catheter implants [7,12,37], three-dimensional conformal external-beam radiotherapy (EBRT) [3,9,35], or intraoperative radiotherapy (IORT) with either electrons [11,18,32,33] or a low-kW X-ray source [14,29,30]. The main advantages of IORT are the possibility of a better localization of the dose in the area at higher risk of local recurrences and the avoidance of 5-6 weeks of EBRT.…”

Full-dose intra-operative radiotherapy with electrons (ELIOT) during

“…On the contrary, Reitsamer [15], in a non-randomized study, showed that the boost given with intra-operative electron radiotherapy is superior to the external breast electron boost irradiation. Partial breast irradiation can be delivered also with interstitial brachytherapy [16][17][18], and more recently by external sources with three-dimensional radiotherapy (3D-RT) and intensity modulated radiotherapy (IMRT) [19][20].…”

Partial breast irradiation: a review of techniques and indications

“…Interstitial implants have been in use for over 10 years and published reports describe excellent results; however, these are mainly single-institution Phase I/II studies [39][40][41][42][43][44][45][46]. The largest matched-pair analysis from the William Beaumont Hospital compared 199 interstitial catheter APBI patients treated between 1980 and 1997 with 199 WBRT patients randomly selected from 709 eligible control subjects [39].…”