“…No clinical experience with any of these agents has been reported. Expanded polytetrafluoroethylene, a biocompatible material, has been used safely and effectively for many years in multiple clinical applications in several surgical areas, including vascular surgery [19,22,27], soft-tissue repair [3], plastic surgery [23], gynaecology [5], cardiac surgery [14] and neurosurgery [13,33]. In long-term follow-up on patients in whom an ePTFE membrane [3,10,27,33] was implanted, the presence of wear debris was not shown; similarly, the implantation of this membrane in the defect of a rachidial laminectomy is not submitted to the same shear forces that prosthetic articular implants are.…”