“…Beyond its welldocumented fitness benefits for virtually all population groups, regular exercise might also have potential neuroprotective effects including improving central nervous system (CNS) blood flow and cognitive function, and preventing neurodegeneration and cognitive decline (Delezie and Handschin, 2018;Liu-Ambrose et al, 2018;Cabral et al, 2019;Valenzuela et al, 2020). While more research is needed, there is preliminary evidence supporting that exercise training might also attenuate, at least partly, the cerebellar degeneration associated with some diseases, and thus potentially alleviate ataxic symptoms (Aranca et al, 2016;Ayvat et al, 2018;Oliveira et al, 2018). In this regard, although there is evidence that exercise training -including aerobic exercises alone or in combination with resistance (strength) training -can improve cardiorespiratory fitness and/or muscle mass/strength in patients with MD (Cejudo et al, 2005;Taivassalo et al, 1996Taivassalo et al, , 1998Taivassalo et al, , 1999Taivassalo et al, , 2001Taivassalo et al, , 2006Adhihetty et al, 2007;Murphy et al, 2008;Jeppesen et al, 2006Jeppesen et al, , 2009Siciliano et al, 2000Siciliano et al, , 2012Bates et al, 2013;Fiuza-Luces et al, 2018a) and in preclinical models of MD (Clark-Matott et al, 2015;Safdar et al, 2011Safdar et al, , 2016Fiuza-Luces et al, 2019;Ross et al, 2019), the evidence regarding potential neuroprotective effects is more scarce, with data supporting aerobic training-induced neuroprotection reported only in the mitochondrial DNA Mutator mouse (Safdar et al, 2011;Clark-Matott et al, 2015;Ross et al, 2019).…”