The Use of Gentian-Violet as a Restrainer in the Isolation of the Pathogenic Molds

Farley, David

doi:10.1001/archderm.1920.02350100047006

Cited by 12 publications

(2 citation statements)

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“…In 1928, a case of staphylococcal meningitis was also cured by intrathecal injections of GV . Throughout the first half of the 20th century, GV was widely adopted for use in a variety of diseases including trench mouth , thrush , impetigo , burns , pinworm , cutaneous and systemic fungal infections . Claims of GV's efficacy during this time period are difficult to ascertain, given that the composition of GV dyes varied, and the authors did not always describe the solutions used in their publications.…”

Section: Introductionmentioning

confidence: 99%

Gentian Violet: a 19th century drug re‐emerges in the 21st century

Maley

Arbiser

2013

Experimental Dermatology

119

108

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Gentian violet (GV) has a long and varied history as a medicinal agent. Historically used as an anti-bacterial and anti-fungal, recent reports have shown its utility as an anti-typranosomal, anti-viral and anti-angiogenic agent. The objective of this paper is to summarize evidence regarding the efficacy, and safety of GV use in dermatology. Recent discoveries have found novel targets of GV, namely NADPH oxidase in mammalian cells and thioredoxin reductase 2 in bacterial, fungal, and parasitic cells. These discoveries have expanded the use of GV in the 21st century. Given that GV is well tolerated, effective and inexpensive, its use in dermatology is predicted to increase.

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Section: Introductionmentioning

confidence: 99%

Gentian Violet: a 19th century drug re‐emerges in the 21st century

Maley

Arbiser

2013

Experimental Dermatology

119

108

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“…The bacteriostatic activity of gentian violet was noted in the late 1800's (Kligler, 1918), but its fungistatic activity was not investigated until several decades later (Farley, 1920;Wideman, 1930;Gomez-Vega, 1935). Its activity against Aspergillus flavus, which produces aflatoxin, was reported first by Aiquel and Herrero (1948) and was confirmed by several laboratories (Doupnik and Bell, 1971;Stewart et al, 1977;Hall and Hamilton, 1982).…”

Section: Introductionmentioning

confidence: 99%

Factors Influencing Antifungal Activity of Gentian Violet in Poultry Feed and Ingredients ,

Tabib

Hamilton

1988

Poultry Science

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The inhibition of fungal activity in poultry feed and ingredients by gentian violet was investigated by measuring respiratory CO2 liberated into the headspace gas above samples of feed and ingredients. Inhibition by gentian violet depended on 1) the lot of corn meal, 2) the concentration of gentian violet, 3) the moisture of the substrate, 4) time of incubation, 5) particle sizes of corn meal and gentian violet, and 6) temperature of a short heating episode mimicking the feed-pelleting process. These same factors were reported earlier to control and limit the activity of organic acid mold inhibitors. These results imply that differences between gentian violet and other mold inhibitors used in poultry feed are quantitative rather than qualitative.

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