The use of gentamicin-coated nails in complex open tibia fracture and revision cases: A retrospective analysis of a single centre case series and review of the literature

Metsemakers, Willem‐Jan; Reul, Maike; Nijs, Stefaan

doi:10.1016/j.injury.2015.09.028

Cited by 95 publications

(68 citation statements)

References 29 publications

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“…Preclinical research studies looking into the risk and progression of bone infection specifically in trauma-relevant models are also scarce [11][12][13], and few specific innovations have been translated from the academic arena and made available to the musculoskeletal trauma surgeon [14][15][16]. In this review, we summarize the preventative, diagnostic and therapeutic guidelines for IFF with an emphasis on the unique aspects of fracture care that distinguish IFF from PJI.…”

Section: Iffmentioning

confidence: 99%

Infection after fracture fixation: Current surgical and microbiological concepts

Metsemakers

Kuehl

Moriarty

et al. 2018

Injury

Self Cite

390

368

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One of the most challenging complications in trauma surgery is infection after fracture fixation (IAFF). IAFF may result in permanent functional loss or even amputation of the affected limb in patients who may otherwise be expected to achieve complete, uneventful healing. Over the past decades, the problem of implant related bone infections has garnered increasing attention both in the clinical as well as preclinical arenas; however this has primarily been focused upon prosthetic joint infection (PJI), rather than on IAFF. Although IAFF shares many similarities with PJI, there are numerous critical differences in many facets including prevention, diagnosis and treatment. Admittedly, extrapolating data from PJI research to IAFF has been of value to the trauma surgeon, but we should also be aware of the unique challenges posed by IAFF that may not be accounted for in the PJI literature. This review summarizes the clinical approaches towards the diagnosis and treatment of IAFF with an emphasis on the unique aspects of fracture care that distinguish IAFF from PJI. Finally, recent developments in anti-infective technologies that may be particularly suitable or applicable for trauma patients in the future will be briefly discussed.

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Section: Iffmentioning

confidence: 99%

Infection after fracture fixation: Current surgical and microbiological concepts

Metsemakers

Kuehl

Moriarty

et al. 2018

Injury

Self Cite

390

368

View full text Add to dashboard Cite

show abstract

“…Expert Tibia Nail (ETN) PROtect™ coated with a biodegradable gentamicin-laden polymer was used for IRIs. When it was used for the prophylaxis of osteomyelitis, no deep infections were observed after the placement of the gentamicin-coated nail and no side effects were reported that were linked to the implant coating [65, 130]. Conway et al used antibiotic cement-coated (ACC) rods for the control of IRIs by providing both the mechanical stability and local delivery of antibiotics.…”

Section: Evidence Of the Anti-infective Prophylactic Therapy Of Coatingmentioning

confidence: 99%

Coatings as the useful drug delivery system for the prevention of implant-related infections

Pan

Zhou

2018

J Orthop Surg Res

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Implant-related infections (IRIs) which led to a large amount of medical expenditure were caused by bacteria and fungi that involve the implants in the operation or in ward. Traditional treatments of IRIs were comprised of repeated radical debridement, replacement of internal fixators, and intravenous antibiotics. It needed a long time and numbers of surgeries to cure, which meant a catastrophe to patients. So how to prevent it was more important than to cure it. As an excellent local release system, coating is a good idea by its local drug infusion and barrier effect on resisting biofilms which were the main cause of IRIs. So in this review, materials used for coatings and evidences of prevention were elaborated.

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“…In a rabbit model, Alt et al [16] found that the gentamicin-HA composite provided a statistically significant reduction in infection rate when compared to uncoated total joint replacements. In patient trials, gentamicin-coated implants have displayed promising preliminary results ( Figure 1) [17][18][19][20] . Limitations of antibiotic coatings include the use of fixed, predetermined antibiotics; limited duration of drug elution; and the risk of developing drug resistance [21] .…”

Section: Antibiotic-based Coatingsmentioning

confidence: 99%

Antimicrobial technology in orthopedic and spinal implants

Eltorai

Haglin

Perera

et al. 2016

WJO

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Infections can hinder orthopedic implant function and retention. Current implant-based antimicrobial strategies largely utilize coating-based approaches in order to reduce biofilm formation and bacterial adhesion. Several emerging antimicrobial technologies that integrate a multidisciplinary combination of drug delivery systems, material science, immunology, and polymer chemistry are in development and early clinical use. This review outlines orthopedic implant antimicrobial technology, its current applications and supporting evidence, and clinically promising future directions.Key words: Antimicrobial; Coated implants; Antibiotic; Antiseptic; Nano-silver; Photoactive Core tip: Infections can hinder orthopedic implant function and retention. Current implant-based antimicrobial strategies largely utilize coating-based approaches in order to reduce biofilm formation and bacterial adhesion. Several emerging antimicrobial technologies that integrate a multidisciplinary combination of drug delivery systems, material science, immunology, and polymer chemistry are in development and early clinical use. This review outlines the latest orthopedic implant antimicrobial technologies-including updates on chitosan

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The use of gentamicin-coated nails in complex open tibia fracture and revision cases: A retrospective analysis of a single centre case series and review of the literature

Cited by 95 publications

References 29 publications

Infection after fracture fixation: Current surgical and microbiological concepts

Infection after fracture fixation: Current surgical and microbiological concepts

Coatings as the useful drug delivery system for the prevention of implant-related infections

Antimicrobial technology in orthopedic and spinal implants

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