2011
DOI: 10.1590/s0100-879x2011007500145
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The use of genes for performance enhancement: doping or therapy?

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Cited by 20 publications
(30 citation statements)
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“…Even though literature presents relevant work related to genic therapy and therapeutics to increase muscle mass 11,25 , no studies were observed that identified the variation of body mass in animals treated with myostatin inhibitor. It is worth to mention that the aerobe exercise protocol was used, what would favor body mass loss.…”
Section: Discussionmentioning
confidence: 99%
“…Even though literature presents relevant work related to genic therapy and therapeutics to increase muscle mass 11,25 , no studies were observed that identified the variation of body mass in animals treated with myostatin inhibitor. It is worth to mention that the aerobe exercise protocol was used, what would favor body mass loss.…”
Section: Discussionmentioning
confidence: 99%
“…EPO is a hormone with 165 amino acids produced mainly in the renal cortex and its production is quickly induced by hypoxia. 3 44 55–57 After being released, EPO binds to the EPO receptor stimulating erythropoiesis (the production of new erythrocytes),40 41 54 58 which increases the number of haemoglobin carrying erythrocytes in the blood. Haemoglobin binds to oxygen with high affinity; although this affinity is reduced by heat or high carbon dioxide concentrations—conditions found in active muscle tissue 54.…”
Section: Properties Targets and Current Status Of Protein Drugs And mentioning
confidence: 99%
“…It is used to treat anaemia caused by kidney disease, cancer or HIV, or for blood loss following surgery or trauma. Instead of giving a patient–donor blood to increase erythrocytes, the patient is injected with EPO to stimulate erythropoiesis 5 44 54–56. Although studies have shown the stimulation of steroidogenesis in Leydig cells by EPO leads to infertility over time,44 EPO has also been found to have neuroprotective properties 40–42 44…”
Section: Properties Targets and Current Status Of Protein Drugs And mentioning
confidence: 99%
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“…Gene therapy techniques can, however, enable the manipulation of biotechnology for illicit use in sport (Mansour, Azzazy, 2009;McKanna, Toriello, 2010;Oliveira et al, 2011). Such a scenario is theoretically possible, but it is not known whether any athletes have already resorted to it.…”
Section: Introductionmentioning
confidence: 99%