The use of gallium-67 in pulmonary disorders

Siemsen, Jan K.; Grebe, S. F.; Waxman, Alan D.

doi:10.1016/s0001-2998(78)80031-2

Cited by 83 publications

(21 citation statements)

References 23 publications

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“…Early studies were performed primarily using 67Ga (Siemsen et al 1978), and this remains the most widely used (Gulaldi et al 1995;Onsel et al 1996;Utsunomiya et al 1997;Degirmenci et al 1998) and best radiopharmaceutical for imaging mycobacterial infections (McAfee 1996). It is a "catch-all" radiopharmaceutical that demonstrates accumulation in infection, inflammation, and neoplasm, but requires a delay of 24-72 h between administration and imaging (Gulaldi et al1995;Onsel et al1996;Utsunomiya et al 1997;Degirmenci et al 1998;O'Doherty et al 1997;Lin and Hsieh 1999) because of prolonged blood clearance and biliary excretion (Gulaldi et al 1995).…”

Section: Gallium Citrate ( 67 Ga)mentioning

confidence: 99%

“…Imaging with 67Ga is a very sensitive indicator of the presence of active tuberculosis (Siemsen et al 1978;Moody and Delbeke 1992;Kao et al 1993) and seems more accurate than physical examination of the neck or plain X-rays of the chest (Goldfarb et al 1997). Active disease results in a positive image in up to 97% of patients (Siemsen et al 1976(Siemsen et al , 1978Walsh et al 1985;Lin and Hsieh 1999).…”

Section: Gallium Citrate ( 67 Ga)mentioning

confidence: 99%

“…Active disease results in a positive image in up to 97% of patients (Siemsen et al 1976(Siemsen et al , 1978Walsh et al 1985;Lin and Hsieh 1999). 67Ga is extremely valuable in differentiating active disease from established scarring, since inactive disease results in a negative image in up to 100% of patients (Siemsen et al 1978;Kao et al 1993). False negative results do occur, however.…”

Section: Gallium Citrate ( 67 Ga)mentioning

confidence: 99%

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Radionuclides in Pulmonary and Extra-Pulmonary Tuberculosis

Hamilton

Al-Nabulsi

2004

Tuberculosis

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Section: Gallium Citrate ( 67 Ga)mentioning

confidence: 99%

Section: Gallium Citrate ( 67 Ga)mentioning

confidence: 99%

Section: Gallium Citrate ( 67 Ga)mentioning

confidence: 99%

See 1 more Smart Citation

Radionuclides in Pulmonary and Extra-Pulmonary Tuberculosis

Hamilton

Al-Nabulsi

2004

Tuberculosis

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“…In 1978 Siemens et al [11] studied 14 patients with sarcoidosis: all of them showed some re gression in 67Ga affinity during steroid therapy: in 1981 Alberts et al [1] recorded that 67Ga accumulation decreased or even disappeared in all their 12 treated patients, and also in a study by Klech et al [7] all pa tients showed a marked regression of 67Ga uptake, or even negative scans after ste roid therapy.…”

Section: Follow-upmentioning

confidence: 99%

“…In the last few years, many reports have focused at tention on 67Ga scintigraphy as an aid in the evaluation of sarcoid activity, especial ly in the follow-up of patients with pro gressive pulmonary sarcoidosis [1,2,7,11,12]. Usually, during follow-up studies, pa tients on steroids are scanned without sus pending therapy.…”

mentioning

confidence: 99%

Assessment of Sarcoidosis Activity by <sup>67</sup>Gallium Lung Scan

Rizzato¹,

Spinelli²,

Tansini³

et al. 1983

Respiration

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71 consecutive patients with histologically confirmed sarcoidosis, in various clinical stages of activity, were submitted to ⁶⁷Ga lung scan, and 23 of them were studied with two or more scans at intervals of 4–6 months. In patients on steroid therapy, the drug was suspended 7 days before scan to avoid the steroids interfering with the gallium (Ga) uptake mechanism. In order to assess the usefulness of ⁶⁷Ga in the evaluation of sarcoid activity, six other parameters of activity were considered, ranging from angiotensin-converting enzyme levels to progressive symptoms, from deteriorating X-ray or pulmonary function tests to clinical or laboratory evidence of prominent extra-thoracic involvement. Our work suggests that Ga scan is more sensitive than chest X-ray in determining the degree and variation of pulmonary sarcoidosis activity, in evaluating the response to therapy, and in foreseeing the relapses. In some cases it gives information not detectable with other noninvasive criteria. The detection of patients with active disease, after discontinuation of steroids 7 days before scan, raises doubts about the opportuneness of scanning patients on steroids, and suggests that further studies on this point are needed.

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Gallium‐67 citrate imaging in underground coal miners

Kanner

Rom

et al. 1985

American J Industrial Med

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Twenty-two underground coal workers with 27 or more years of coal dust exposure were studied with gallium-67 citrate (Ga-67) imaging. Radiographic evidence of coal workers pneumoconiosis (CWP) was present in 12 subjects. The Ga-67 scan was abnormal in 11 of 12 with, and 9 of 10 without, CWP. The Ga-67 uptake index was significantly correlated with total dust exposure (p less than 0.01) and approached significant correlation with the radiographic profusion of the nodules (0.10 greater than p greater than 0.05). There was no correlation between Ga-67 uptake and spirometric function, which was normal in this group of patients; furthermore, increased lung uptake of gallium did not indicate a poor prognosis in subjects no longer exposed to coal dust. While coal dust exposure may be associated with positive Ga-67 lung scan in coal miners with many years of coal dust exposure, the scan provided no information not already available from a careful exposure history and a chest radiograph. Since Ga-67 scanning is a relatively expensive procedure we would recommend that its use in subjects with asymptomatic CWP be limited to an investigative role and not be made part of a routine evaluation.

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The use of gallium-67 in pulmonary disorders

Cited by 83 publications

References 23 publications

Radionuclides in Pulmonary and Extra-Pulmonary Tuberculosis

Radionuclides in Pulmonary and Extra-Pulmonary Tuberculosis

Assessment of Sarcoidosis Activity by <sup>67</sup>Gallium Lung Scan

Gallium‐67 citrate imaging in underground coal miners

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