The use of fructosamine in cystic fibrosis-related diabetes (CFRD) screening

Abstract

FSF correlated with both OGTT results and FEV, and reliably identified patients with abnormal OGTT results. This simple blood test shows potential as an effective tool in CFRD screening.

Screening for cystic fibrosis‐related diabetes and prediabetes: Evaluating 1,5‐anhydroglucitol, fructosamine, glycated albumin, and hemoglobin A1c

“…Fructosamine is a ketoamine formed secondary to non‐enzymatic protein glycation and it has traditionally been used in situations where HbA1c is unreliable . Studies have shown that FA correlates with total protein and albumin concentrations; consequently, correction for total protein or albumin improves both diagnostic performance and correlation with HbA1c in identifying diabetes . A small study recently examined the utility of FA in CFRD and found that FA appeared to be a reliable tool for CFRD screening and correlated inversely with FEV1 in individuals with CFRD .…”

“…18 Studies have shown that FA correlates with total protein and albumin concentrations; consequently, correction for total protein or albumin improves both diagnostic performance and correlation with HbA1c in identifying diabetes. 14,31 A small study recently examined the utility of FA in CFRD and found that FA appeared to be a reliable tool for CFRD screening and correlated inversely with FEV1 in individuals with CFRD. 14 The findings in our population, however, differ and this may be secondary to differences in demographics as our population was younger and included a higher proportion of individuals with CFPD and CFRD.…”

“…14,31 A small study recently examined the utility of FA in CFRD and found that FA appeared to be a reliable tool for CFRD screening and correlated inversely with FEV1 in individuals with CFRD. 14 The findings in our population, however, differ and this may be secondary to differences in demographics as our population was younger and included a higher proportion of individuals with CFPD and CFRD. Our population was also healthier overall with less variability in pulmonary function.…”

Cystic fibrosis year in review 2018, part 2

“…It was concluded that FSF could distinguish patients with normal versus abnormal glucose tolerance. 33 Evaluation of all of these markers in 93 patients ages 6 to 25 years with CF and healthy controls, showed correlation with CGM, but none of the newer markers had stronger correlation than hemoglobin A1C. 34…”

“…IQR] 1301 kcal/d vs 686; P < .0001) and proportion of energy intake (median [IQR] 44%[34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] vs 31%[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43]; P < .0001). Thus, while children with CF met their energy requirements and ate ample fat, this was largely due to ingestion of EDNP foods.…”