The use of fibrin sealant to prevent major complications following laparoscopic gastric bypass: results of a multicenter, randomized trial

Silecchia, Gianfranço; Boru, Cristian Eugeniu; Mouïel, J; Rossi, Marco; Anselmino, Marco; Morino, Mario; Toppino, M; Gaspari, Achille; Gentileschi, Paolo; Tacchino, Roberto M.; Basso, Nicola

doi:10.1007/s00464-008-9885-0

Cited by 77 publications

(35 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although other studies have described the effectiveness of fibrin glue applied to anastomoses to prevent leakage [31][32][33]41], they give no information about the effect of applying Coseal to gastrointestinal anastomoses. In our study, the proximal anastomoses showed a similar resistance to pressure, regardless of the treatment used.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Protection of intestinal anastomosis with biological glues: an experimental randomized controlled trial

et al. 2011

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…Previous studies have described the use of biological sealants to prevent anastomotic leakage in other types of surgery, such as laparoscopic gastric bypass [29] or cardiovascular surgery [30], but very few studies [31][32][33] are available on the role of biological sealants in the prevention of anastomotic leakage in colorectal surgery.…”

Section: Introductionmentioning

confidence: 99%

Protection of intestinal anastomosis with biological glues: an experimental randomized controlled trial

et al. 2011

View full text Add to dashboard Cite

show abstract

“…In a randomized study on esophageal anastomoses in infants born with esophageal atresia, a significantly reduced incidence of anastomotic leakage and stricture was found in the group sealed with FG [85]. Two human studies on FG sealing of anastomoses in patients with Roux-en-Y gastric bypass found a nonsignificantly decreased incidence of anastomotic leakage in the sealing group [86,87]. Another human study on anastomotic leakage after laparoscopic resection of rectal cancer found a leakage rate of 5.8% in the FG-sealed group compared with 10.9% in the nonsealed group.…”

Section: Discussionmentioning

confidence: 99%

Fibrin Glue Does Not Improve Healing of Gastrointestinal Anastomoses: A Systematic Review

et al. 2014

View full text Add to dashboard Cite

Background/Aim: Anastomotic leakage remains a frequent and serious complication in gastrointestinal surgery. In order to reduce its incidence, several clinical and experimental studies on anastomotic sealing have been performed. In a number of these studies, the sealing material has been fibrin glue (FG), and the results in individual studies have been varying. The positive effect of anastomotic sealing with FG might be due to the mechanical/physical properties, the increased healing of the anastomoses or both. The aim of this systematic review was to evaluate the existing evidence on the healing effects of FG on gastrointestinal anastomoses. Methods: PubMed, EMBASE and the Cochrane databases were searched for studies evaluating the healing process of gastrointestinal anastomoses after any kind of FG application. The search period was from 1953 to December 2013. Results: Twenty-eight studies were included in the qualitative synthesis. These studies were all experimental studies, since no human studies used histological or biochemical evaluation of healing. In 7 of the 28 studies, a positive effect of FG on healing was found, while 8 studies reported a negative effect and 11 studies found no effect. Furthermore, 2 studies reported unclear results. The difference in the study outcome was independent of the study design and the type of FG used. Conclusion: In the available studies, FG did not consistently have a positive influence on the healing of gastrointestinal anastomoses. It is consequently plausible that the positive effect of FG sealing of gastrointestinal anastomoses, if there is any, may be due to a mechanical sealing effect rather than due to improved healing per se.

show abstract

“…[10,11] Fibrin glue is being used in various pathologies including upper gastrointestinal tract perforations, [7,12] fistulas [13,14] and leaks. [15,16] DuraSeal, which is an absorbable synthetic hydrogel, has blue solution and limpid solution. DuraSeal is a newly introduced material aiming to minimize leaks in various organs, such as cerebrospinal fluid in neurosurgery, air in thoracic surgery and blood in vascular surgery.…”

Section: Resultsmentioning

confidence: 99%

Comparison of classical surgery and sutureless repair with DuraSeal or fibrin glue for duodenal perforation in rats

Avcı

Yüceyar

Aytaç³

et al. 2011

Ulus Travma Acil Cerrahi Derg

View full text Add to dashboard Cite

AMAÇBu çalışmada, sıçanlarda oluşturulan deneysel duodenum perforasyonunda klasik cerrahi teknikler ile adezyon bariyerleri olan DuraSeal ya da fibrin yapıştırıcıyla yapılan dikişsiz onarım tekniklerinin karşılaştırılması amaçlandı. GEREÇ VE YÖNTEMKırk adet yetişkin, ağırlıkları 250-300 g arasında olan, dişi Wistar Albino sıçan rastgele dört adet eşit gruba ayrıldı. Primer onarım grubu, primer onarım ve omentoplasti grubu, fibrin yapıştırıcı uygulanan grup ve DuraSeal uygulanan grup. Doku iyileşmesini değerlendirmek amacıyla patlama basıncı, doku hidroksiprolin seviyesi ve histopatolojik inceleme parametre olarak kullanıldı. BULGULARPrimer onarım, primer onarım ve omentoplasti gruplarının patlama basıncı değerleri fibrin yapıştırıcı ve DuraSeal grubu patlama basıncı değerlerine göre anlamlı olarak yüksek-ti (p<0,001). Biyokimyasal ve histolojik parametreler açı-sından tüm gruplar arasında anlamlı farklılık yoktu. SONUÇDeğerlendirdiğimiz dikişsiz onarım tekniklerinin konvansiyonel onarım tekniklerine üstün etkilerinin olmadığını gözlemledik. Dikişsiz onarım gruplarının sonuçları benzerdi. DuraSeal, fibrin yapıştırıcı gibi dikişsiz onarım alanın-da alternatif olabilir. Bu çıkarım farklı yara iyileşmesi belirteçleri ve farklı yöntemlerle planlanmış çalışmalarla desteklenmelidir.Anahtar Sözcükler: DuraSeal; duodenal perforasyon; fibrin yapış-tırıcı; dikişsiz tamir.

show abstract

The use of fibrin sealant to prevent major complications following laparoscopic gastric bypass: results of a multicenter, randomized trial

Abstract: The use of fibrin sealant in laparoscopic RYGBP may be beneficial in reducing the reintervention rate for major perioperative (<30 days) complications. Larger studies are needed.

Cited by 77 publications

References 29 publications

Protection of intestinal anastomosis with biological glues: an experimental randomized controlled trial

Protection of intestinal anastomosis with biological glues: an experimental randomized controlled trial

Fibrin Glue Does Not Improve Healing of Gastrointestinal Anastomoses: A Systematic Review

Comparison of classical surgery and sutureless repair with DuraSeal or fibrin glue for duodenal perforation in rats

Contact Info

Product

Resources

About