The Use of Fibers in Bone Tissue Engineering

Petre, Daniela G.; Leeuwenburgh, Sander C.G.

doi:10.1089/ten.teb.2020.0252

Cited by 23 publications

(19 citation statements)

References 163 publications

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“…Fiber is the basic element of textiles. As a material integrating tradition and innovation, fibers have been widely used in the fields of clothing, electronics, filtration, catalysis, biomedicine, and so on. − Among them, fiber-based flexible and wearable electronics have gained increasing attention in recent years. − Because of the excellent flexibility, light weight, structural designability, and wearing comfort, various fiber-based electronic materials and devices have been designed and constructed, putting forward an urgent need for conductive fibers with high flexibility and robustness. − Compared with the conductive fibers prepared by metal or inorganic carbon materials, conductive fibers made from polymers possess many advantages including easy processing, high flexibility, low cost, nontoxicity, and good environmental stability. − In particular, poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) is the most promising polymer due to its high conductivity and water solubility, and it has been widely used in light-emitting diodes, supercapacitors, sensors, thermoelectric devices, and so on. − …”

Section: Introductionmentioning

confidence: 99%

Highly Conductive, Ultrastrong, and Flexible Wet-Spun PEDOT:PSS/Ionic Liquid Fibers for Wearable Electronics

Chen

Luo

et al. 2023

ACS Appl. Mater. Interfaces

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Conductive poly (3,4-ethylenedioxythiophene):poly-(styrenesulfonate) (PEDOT:PSS) fibers with high electrical conductivity, flexibility, and robustness are urgently needed for constructing wearable fiber-based electronics. In this study, the highly conductive (4288 S/cm), ultrastrong (a high tensile strength of 956 MPa), and flexible (a low Young's modulus of 3.8 GPa) PEDOT:PSS/1-ethyl-3-methylimidazolium dicyanamide (EMIM:DCA) (P/ED) fiber was prepared by wet-spinning and a subsequent H 2 SO 4 -immersion−drawing process. As far as we know, this is the best performance of the PEDOT:PSS fiber reported so far. The structure and conformation of the P/ED fiber were characterized by FESEM, XPS, Raman spectroscopy, UV−vis−NIR spectroscopy, and WAXS. The results show that the high performances of the P/ED fiber are mainly attributed to the massive removal of PSS and high degree of crystallinity (87.9%) and orientation (0.71) of PEDOT caused by the synergistic effect of the ionic liquid, concentrated sulfuric acid, and high stretching. Besides, the P/ED fiber shows a small bending radius of 0.1 mm, and the conductivity of the P/ED fiber is nearly unchanged after 1000 repeated cycles of bending and humidity changes within 50−90%. Based on this, various P/ED fiberbased devices including the circuit connection wire, thermoelectric power generator, and temperature sensor were constructed, demonstrating its wide applications for constructing flexible and wearable electronics.

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Section: Introductionmentioning

confidence: 99%

Highly Conductive, Ultrastrong, and Flexible Wet-Spun PEDOT:PSS/Ionic Liquid Fibers for Wearable Electronics

Chen

Luo

et al. 2023

ACS Appl. Mater. Interfaces

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“…Cells could constantly respond to varied ECM features to change corresponding gene expression and cell function, thus finally achieving desired tissue function and homeostasis maintenance [ 6–8 ]. Just because of the inherent ECM-mimicking structure, fibrous material has been studied and utilized as an essential biomaterial [ 9–15 ] and has been widely used in biomedical fields such as surgical sutures [ 16–18 ], wound dressings [ 19–25 ] and tissue engineering [ 5 , 26–31 ]. The diameter of the widely used fibrous biomaterials usually ranges from several hundred nanometers to several microns [ 32–34 ], and the diameter of the surgical suture can reach tens of microns [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Fiber diameters and parallel patterns: proliferation and osteogenesis of stem cells

Fan

Kundu

et al. 2023

Regenerative Biomaterials

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Due to the innate extracellular matrix mimicking features, fibrous materials exhibited great application potential in biomedicine. In developing excellent fibrous biomaterial, it is essential to reveal the corresponding inherent fiber features' effects on cell behaviors. Due to the inevitable “interference” cell adhesions to the background or between adjacent fibers, it is difficult to precisely reveal the inherent fiber diameter effect on cell behaviors by using a traditional fiber mat. A single-layer and parallel-arranged polycaprolactone fiber pattern platform with an excellent non-fouling background is designed and constructed herein. In this unique material platform, the “interference” cell adhesions through interspace between fibers to the environment could be effectively ruled out by the non-fouling background. The “interference” cell adhesions between adjacent fibers could also be excluded from the sparsely arranged (SA) fiber patterns. The influence of fiber diameter on stem cell behaviors is precisely and comprehensively investigated based on eliminating the undesired “interference” cell adhesions in a controllable way. On the SA fiber patterns, small diameter fiber (SA-D1, D1 means one μm in diameter) may seriously restrict cell proliferation and osteogenesis when compared to the middle (SA-D8) and large (SA-D56) ones and SA-D8 shows the optimal osteogenesis enhancement effect. At the same time, the cells present similar proliferation ability and even the highest osteogenic ability on the densely arranged (DA) fiber patterns with small diameter fiber (DA-D1) when compared to the middle (DA-D8) and large (DA-D56) ones. The “interference” cell adhesion between adjacent fibers under dense fiber arrangement may be the main reason for inducing these different cell behavior trends along with fiber diameters. Related results and comparisons have illustrated the effects of fiber diameter on stem cell behaviors more precisely and objectively, thus providing valuable reference and guidance for developing effective fibrous biomaterials.

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“…Bone tissue engineering is one of the major research targets in current regenerative medicine. Bioceramics (e.g., hydroxyapatite, carbonated apatite) [ 1 ] and polymers (e.g., collagen, polylactic acid) [ 2 ] have been widely applied for this purpose. Nevertheless, these materials present limitations related to mimicking the biological and/or biomechanical properties of natural bone apatite.…”

Section: Introductionmentioning

confidence: 99%

“…

acid) [2] have been widely applied for this purpose. Nevertheless, these materials present limitations related to mimicking the biological and/or biomechanical properties of natural bone apatite.

…”

mentioning

confidence: 99%

Distinct Morphologies of Bone Apatite Clusters in Endochondral and Intramembranous Ossification

et al. 2022

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acid) [2] have been widely applied for this purpose. Nevertheless, these materials present limitations related to mimicking the biological and/or biomechanical properties of natural bone apatite. For instance, although hydroxyapatite-based bone mimetics present chemical similarities with natural bone, they show poor resorbability and remain in the transplanted area even after 10 years. [1] Alternative therapeutics using growth factors (e.g., bone morphogenetic protein 2 and basic fibroblast growth factor), [3] or cells, such as osteoblasts or mesenchymal stem/progenitor cells (MSCs), have also been introduced. [4] These methods, however, are costly and time-consuming, because cell therapies usually involve the transplantation of mature osteoblasts, and osteoblastic differentiation requires ≈2-3 weeks. [5] Recent multidisciplinary approaches merging the knowledge in developmental biology with methods/techniques in tissue engineering have enabled the development of unprecedented technologies for cartilage and bone tissue engineering. [6] In this context, previous approaches for promoting bone regeneration were suboptimal as they were essentially based only on the concept of osteoblast-driven intramembranous ossification (IO).Bone is formed through two distinct processes: IO and endochondral ossification (EO). [7] Intramembranous ossification begins inside the osteoblast-secreted extracellular vesicles, i.e., matrix vesicles (MVs), and forms the flat bones (e.g., skull) and the cortical bone. [7][8][9] Matrix vesicles refer to small (20-200 nm) spherical bodies transported via lysosome and secreted by exocytosis from the cells, mainly osteoblasts. [10,11] On the other hand, in EO, bone replaces a cartilage intermediate. [12] Recently, EO was shown to initiate from chondrocyte-derived plasma membrane nanofragments (PMNFs), in the absence of osteoblasts and MVs. [8,13] Previous studies have shown that the membrane and enzymes constituting MVs are different from the parent cell membrane. [14,15] On the other hand, PMNFs are direct fragments of the parent cell membrane. Thus, MVs and PMNFs could be regarded to have different composition in phospholipids and enzymes, [14,16] and could be leading to the formation of apatite clusters with different structures. However, little is known about the exact morphology of bone apatite clusters formed from MVs (IO) and PMNFs (EO).

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The Use of Fibers in Bone Tissue Engineering

Cited by 23 publications

References 163 publications

Highly Conductive, Ultrastrong, and Flexible Wet-Spun PEDOT:PSS/Ionic Liquid Fibers for Wearable Electronics

Highly Conductive, Ultrastrong, and Flexible Wet-Spun PEDOT:PSS/Ionic Liquid Fibers for Wearable Electronics

Fiber diameters and parallel patterns: proliferation and osteogenesis of stem cells

Distinct Morphologies of Bone Apatite Clusters in Endochondral and Intramembranous Ossification

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