The Use of Experimental Factorial Design for Analysing the Effect of Spray Dryer Operating Variables on the Production of Tomato Powder

Optimisation of spray drying process conditions for sugar nanoporous microparticles (NPMPs) intended for inhalation

“…The coefficients of the model equation are negative for gas flow and positive for pump Page 16 of 42 A c c e p t e d M a n u s c r i p t 15 setting and feed concentration, i.e., as gas flow decreases and pump setting and feed concentration increases, particle size increases which is consistent with previous studies 350 (Stähl et al, 2002;Al-Asheh et al, 2003;Maury et al, 2005;Tajber et al, 2009).…”

“…The latter studies showed an increase in particle size with increasing inlet temperatures, due to agglomeration of particles at higher temperatures and to hardening of the droplet (Stähl et al, 2002;Al-Asheh et al, 2003).…”

“…When developing a new dry powder inhaler it is crucial to have a well characterised spray drying method and optimisation of the process involves an evaluation of the spray drying parameters, the liquid feed and product characteristics. Billon et al (2000), Stähl et al (2002), Al-Asheh et al (2003) and Tajber et al (2009) 95 have used factorial design studies to optimise spray drying processes, proving the usefulness of such statistical tools in understanding the process, saving time and reducing material costs. Maltesen et al (2008) carried out a design of experiment on the spray drying of insulin intended for inhalation on a Büchi Mini Spray dryer B-290 to understand the effects ofM a n u s c r i p t 5 process and formulation on powder/particle characteristics, such as yield, particle size, density, morphology and moisture content.…”

Spray-dried tomato powder: reconstitution properties and colour

“…The value for the moisture content varied from 4.00 to 6.8 g/100g (dry matter), higher than the values found by Al Asheh et al, 2003 (3-1%) for the tomato powder in other drying conditions. However, in general, it was reduced by the increase of the inlet air temperature and of the atomization speed (Masters, 1991;Al-Asheh et al, 2003;. The values for the solubility were from 17.65 to 26.73%, low values when compared to the powdered tropical fruits, which shown values varying from 44.6 to 57.59%, for the passion fruit juice (Jorge et al, 2003) and 81.56% for the pineapple juice (Abadio et al, 2004).…”

Encapsulation of Bitter gourd (Momordica charantia L.) Extract by Spray Drying Technique

“…In the spray-drying process, the liquid feed is pumped into the drying chamber through an atomizing system 5,6 . It results in powders with good quality, low water activity, easier handling and storage and also protects the active material against undesirable reactions.…”