The use of enzymatic drugs in patients with chronic prostatitis: the current view

Зайцев, А. В.; Ходырева, Л А; Dudareva, A. A.; Pushkar, Dmitry

doi:10.17116/klinderma201615353-60

Cited by 5 publications

(1 citation statement)

References 21 publications

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“…Neither are there any clear recommendations for the prevention and treatment of UPS, as a result of which the only effective form of medical care today is symptomatic therapy—involving the continuing intake of strong pain medications, antidepressants, and anticonvulsants [ 4 , 9 ]. In the methodological recommendations on CPP, published under the auspices of the the Moscow Department of Health (dated 14 July 2016), it is noted that there is no specific accepted treatment for UPS [ 10 ]. The approach should be interdisciplinary and the treatment should be multimodal, with the general principles of chronic pain syndrome management being applied [ 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

New Approaches in the Study of the Pathogenesis of Urethral Pain Syndrome

et al. 2020

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Introduction: Urethral pain syndrome (UPS) is still a pathology in which the diagnosis is formulated as a “diagnosis of exclusion”. The exact pathogenetic mechanisms are not yet fully understood and clear recommendations for the prevention and treatment of UPS are absent. Methods and Participants: A clinical and laboratory evaluation of 55 patients with established UPS included history taking, basic laboratory tests (e.g., complete blood count and clinical urine test), physical examination, uroflowmetry, and cystourethroscopy. Additionally, transvaginal ultrasound (TVUS) with compression elastography and cross-polarization optical tomography (CP OCT) were performed in 24 and 33 patients with UPS, respectively. The control group consisted of 14 patients with no complaints from the urinary system. Results: TVUS showed an expansion in the diameter of the internal lumen of the urethra, especially in the proximal region compared with the norm. Compression elastography revealed areas with increased stiffness (presence of fibrosis) in urethral and surrounding tissues. The performed CP OCT study showed that in UPS, the structure of the tissues in most cases was changed: trophic alterations in the epithelium (hypertrophy or atrophy) and fibrosis of underlying connective tissue were observed. The proximal fragment of the urethra with UPS underwent changes identical to those of the bladder neck. Conclusion: This paper showed that the introduction of new technology—CP OCT—in conjunction with TVUS will allow verification of structural changes in tissues of the lower urinary tract at the level of their architectonics and will help doctors understand better the basics of the UPS pathogenesis.

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Section: Introductionmentioning

confidence: 99%

New Approaches in the Study of the Pathogenesis of Urethral Pain Syndrome

et al. 2020

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Impact of Ultrasonic Vibrations on the Stability of Bovhyaluronidase Azoximer in Solution

Krasheninnikov,

Sepp,

Bakulin

et al. 2024

Pharm Chem J

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Quality of life of the patients with chronic prostatitis under the influence of complex balneopeloid and enzyme therapy with Longidase

Mkrtchyan,

Gusova,

Emkuzhev

et al. 2024

Russian Journal of Physiotherapy, Balneology and Rehabilitation

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BACKGROUND: In modern medicine, among the main indicators of the effectiveness of therapeutic measures, the quality of life of the patient is singled out, which allows determining the degree of recovery of physical and mental health after treatment of acute conditions. AIM: to evaluate the effectiveness of complex balneopeloid and enzyme therapy with longidase according to the monitoring of the quality of life of the patients suffering from chronic bacterial prostatitis. MATERIALS AND METHODS: There have been observed 54 patients with chronic prostatitis. They were divided into 2 groups by simple randomization: in the comparison group (n=26) the patients were prescribed exercise therapy, internal and external administration of mineral water of Zheleznovodsk type, peloidotherapy with silt sulfide mud topically, antibiotic therapy with ceftriaxone, phytomicroclysters; in the main group (n=28), the patients additionally underwent antibiotic and enzyme therapy by peripheral indirect lymphotropic therapy. The efficiency was assessed using validated Quality of Life questionnaires: Chronic Prostatitis Symptom Scale (NIH-CPS) and SF-36 General Health Questionnaire (Social Functioning-36). RESULTS: The analysis of the clinical effect of the new treatment technology revealed its advantage over the standardized therapy, which is proven by the monitoring of QoL indicators for 1 year after the spa treatment: recovery of QoL in the main group immediately after the treatment occurred by 59.7% (p 0.01), 6 months later ― by 72.7% (p 0.01), with a slight decrease in the rate in 12 months ― by 64.9% (p 0.01). The dynamics of physical and mental health indicators on the SF-36 scale was also observed with the same degree of confidence: compared with the baseline, the average improvement was 25.5% (p 0.01), 33.6% (p 0.01) and 27.3% (p 0.01) respectively. In the comparison group, the dynamics of indicators for all NIH-CPSI and SF-36 scales was also significant, but lower than similar indicators in the main group by 23–25% on average (p 0.01) and 12–15%, respectively. CONCLUSION: The results of the study indicate the high effectiveness of complex balneopeloid and lymphotropic therapy with the patients suffering from chronic prostatitis at the stage of spa treatment.

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The use of enzymatic drugs in patients with chronic prostatitis: the current view

Cited by 5 publications

References 21 publications

New Approaches in the Study of the Pathogenesis of Urethral Pain Syndrome

New Approaches in the Study of the Pathogenesis of Urethral Pain Syndrome

Impact of Ultrasonic Vibrations on the Stability of Bovhyaluronidase Azoximer in Solution

Quality of life of the patients with chronic prostatitis under the influence of complex balneopeloid and enzyme therapy with Longidase

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